Local Betamethasone Versus Triamcinolone Injection in Management of Thyroid Eye Disease

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

92

Participants

Timeline

Start Date

December 1, 2021

Primary Completion Date

October 1, 2023

Study Completion Date

October 30, 2023

Conditions
Thyroid Eye Disease
Interventions
PROCEDURE

peri-levator betamethasone injection

The injection dose was 1 ml of betamethasone suspension (1 ml contains 5 mg betamethasone dipropionate \&2 mg betamethasone sodium phosphate). The needle was introduced percutaneously superior to the globe and advanced towards the orbital roof to a depth of approximately 15 mm where the injection was delivered. The injection was repeated every 4 weeks according to the clinical response up to 5 injections.

PROCEDURE

peri-levator triamcinolone injection

The needle was introduced percutaneously superior to the globe and advanced towards the orbital roof to a depth of approximately 15 mm where 1ml (40mg/ml) triamcinolone acetate was injected. The injection was repeated every 4 weeks according to the clinical response up to 5 injections.

PROCEDURE

peri-levator and retrobulbar betamethasone injection

In addition to peri-levator betamethasone injection for UER, a retrobulbar injection for proptosis was given with the needle introduced through the skin of the lateral one-third of the lower eyelid and passed posteriorly, medially, and upward to reach the retrobulbar space.

PROCEDURE

peri-levator and retrobulbar triamcinolone injection

In addition to peri-levator triamcinolone injection for UER, a retrobulbar injection for proptosis was given with the needle introduced through the skin of the lateral one-third of the lower eyelid and passed posteriorly, medially, and upward to reach the retrobulbar space.

Trial Locations (1)

Unknown

Assiut university, Asyut

All Listed Sponsors
lead

Assiut University

OTHER