Local Betamethasone Versus Triamcinolone Injection in Management of Thyroid Eye Disease

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

92

Participants

Timeline

Start Date

December 1, 2021

Primary Completion Date

October 1, 2023

Study Completion Date

October 30, 2023

Conditions
Thyroid Eye Disease
Interventions
PROCEDURE

peri-levator betamethasone injection

The injection dose was 1 ml of betamethasone suspension (1 ml contains 5 mg betamethasone dipropionate \&2 mg betamethasone sodium phosphate). The needle was introduced percutaneously superior to the globe and advanced towards the orbital roof to a depth of approximately 15 mm where the injection was delivered. The injection was repeated every 4 weeks according to the clinical response up to 5 injections.

PROCEDURE

peri-levator triamcinolone injection

The needle was introduced percutaneously superior to the globe and advanced towards the orbital roof to a depth of approximately 15 mm where 1ml (40mg/ml) triamcinolone acetate was injected. The injection was repeated every 4 weeks according to the clinical response up to 5 injections.

PROCEDURE

peri-levator and retrobulbar betamethasone injection

In addition to peri-levator betamethasone injection for UER, a retrobulbar injection for proptosis was given with the needle introduced through the skin of the lateral one-third of the lower eyelid and passed posteriorly, medially, and upward to reach the retrobulbar space.

PROCEDURE

peri-levator and retrobulbar triamcinolone injection

In addition to peri-levator triamcinolone injection for UER, a retrobulbar injection for proptosis was given with the needle introduced through the skin of the lateral one-third of the lower eyelid and passed posteriorly, medially, and upward to reach the retrobulbar space.

Trial Locations (1)

Unknown

Assiut university, Asyut

All Listed Sponsors
lead

Assiut University

OTHER

NCT04976816 - Local Betamethasone Versus Triamcinolone Injection in Management of Thyroid Eye Disease | Biotech Hunter | Biotech Hunter