Pembrolizumab Plus Lenvatinib in Combination With Belzutifan in Solid Tumors (MK-6482-016)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

730

Participants

Timeline

Start Date

August 18, 2021

Primary Completion Date

March 22, 2027

Study Completion Date

March 22, 2027

Conditions
Neoplasm Malignant
Interventions
DRUG

Pembrolizumab

Pembrolizumab 400 mg administered Q6W via IV infusion

DRUG

Belzutifan

Belzutifan 120 mg administered QD via oral tablet

DRUG

Lenvatinib

Lenvantinib dose for HCC is 8 mg QD for body weight \<60 kg and 12 mg QD for body weight ≥ 60 kg administered via oral capsule. For all other tumors, the lenvatinib dose is 20 mg QD administered via oral capsule

Trial Locations (57)

1023

Auckland City Hospital-Liver Research Unit ( Site 4201), Grafton

Auckland City Hospital-Cancer & Blood Research ( Site 4200), Auckland

1200

Cliniques universitaires Saint-Luc-Medical Oncology ( Site 1001), Brussels

2145

Westmead Hospital-Department of Medical Oncology ( Site 4001), Westmead

2250

Gosford Hospital-Oncology Trials ( Site 4004), Gosford

2650

Antwerp University Hospital-Oncology ( Site 1002), Edegem

3000

UZ Leuven ( Site 1000), Leuven

3076

Northern Hospital-Department of Medical Oncology ( Site 4003), Epping

3144

Cabrini Hospital - Malvern-Cabrini Institute ( Site 4000), Malvern

5530

Université Catholique de Louvain-Namur - Centre Hospitalier -Oncology ( Site 1003), Namur

8800

AZ Delta vzw ( Site 1004), Roeselare

10065

Memorial Sloan Kettering Cancer Center ( Site 5050), New York

15706

CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 1807), Santiago de Compostela

20016

Sibley Memorial Hospital ( Site 5051), Washington D.C.

21287

Johns Hopkins Hospital-Sidney Kimmel Comprehensive Cancer Center - GI and Immunology ( Site 5048), Baltimore

22031

Inova Schar Cancer Institute ( Site 5039), Fairfax

24014

Blue Ridge Cancer Care ( Site 5053), Roanoke

25000

CHU Besançon-Medical oncology ( Site 1101), Besançon

27710

Duke Cancer Institute ( Site 5026), Durham

28007

HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 1801), Madrid

29200

CHU Brest Cavale Blanche ( Site 1107), Brest

32610

University of Florida College of Medicine ( Site 5015), Gainesville

33011

Hospital Universitario Central de Asturias-Medical Oncology ( Site 1802), Oviedo

34298

Institut Regional du Cancer Montpellier ( Site 1106), Montpellier

35042

Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 1103), Rennes

38700

Centre Hospitalier Universitaire de Grenoble-Medical Oncology ( Site 1105), La Tronche

42601

Keimyung University Dongsan Hospital CRC room 1 ( Site 4104), Daegu

48202

Brigitte Harris Cancer Pavilion ( Site 5055), Detroit

53792

University of Wisconsin Hospitals and Clinics ( Site 5037), Madison

58128

Chonnam National University Hwasun Hospital-Hemato-Oncology ( Site 4105), Hwasun Gun

77030

University of Texas MD Anderson Cancer Center-Gastrointestinal Medical Oncology ( Site 5049), Houston

84000

Sainte Catherine Institut du Cancer Avignon Provence ( Site 1108), Avignon

85724

University of Arizona Cancer Center-University of Arizona Cancer Center - North Campus ( Site 5047), Tucson

90048

Cedars-Sinai Medical Center ( Site 5045), Los Angeles

91010

City of Hope Comprehensive Cancer Center ( Site 5002), Duarte

92110

Hôpital Beaujon-Oncologie Digestive ( Site 1104), Clichy

94158

UCSF Medical Center at Mission Bay ( Site 5021), San Francisco

98405

Northwest Medical Specialties, PLLC ( Site 5025), Tacoma

3109601

Rambam Health Care Campus-Oncology ( Site 1300), Haifa

4800827

Centro Investigación del Cáncer James Lind ( Site 3107), Temuco

5265601

Sheba Medical Center-ONCOLOGY ( Site 1302), Ramat Gan

5500242

Clínica Puerto Montt ( Site 3110), Port Montt

6423906

Sourasky Medical Center-Oncology ( Site 1301), Tel Aviv

7500921

FALP-UIDO ( Site 3102), Santiago

7510032

Oncovida ( Site 3108), Santiago

8420383

Bradfordhill-Clinical Area ( Site 3100), Santiago

9112001

Hadassah Medical Center-Oncology ( Site 1303), Jerusalem

06510

Yale-New Haven Hospital-Yale Cancer Center ( Site 5013), New Haven

6229 HX

Maastricht UMC+-Medical Oncology ( Site 1501), Maastricht

2333 ZA

Leids Universitair Medisch Centrum-Medical Oncology ( Site 1504), Leiden

3584 CX

Universitair Medisch Centrum Utrecht-Medical Oncology ( Site 1503), Utrecht

03080

Seoul National University Hospital-Internal Medicine ( Site 4103), Seoul

03722

Severance Hospital, Yonsei University Health System-Medical oncology ( Site 4100), Seoul

05505

Asan Medical Center-Department of Oncology ( Site 4101), Seoul

06351

Samsung Medical Center-Division of Hematology/Oncology ( Site 4102), Seoul

08916

Hospital Germans Trias i Pujol-Instituto Catalán de Oncología de Badalona ( Site 1806), Badalona

08035

Hospital Universitari Vall d'Hebron-Oncology ( Site 1800), Barcelona

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY