Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

864

Participants

Timeline

Start Date

June 23, 2022

Primary Completion Date

March 18, 2026

Study Completion Date

June 25, 2032

Conditions
Multiple Myeloma
Interventions
DRUG

Dexamethasone

Oral dexamethasone 40mg on days 1, 8, 15, 22 of a 28-day cycle

DRUG

Daratumumab

Subcutaneous Daratumumab 1800mg on Days 1, 8, 15 and 22 for Cycles 1 to 2, on Days 1 and 15 for Cycles 3 to 6, and then on Day 1 for Cycle 7+ of a 28-day cycle

DRUG

Bortezomib

Subcutaneous Bortezomib 1.3 mg/m2 on Days 1, 4, 8 and 11 of each 21-day cycle for a total of 8 cycles.

DRUG

Iberdomide

Oral Iberdomide 1.0mg on Days 1 to 21 of a 28-day cycle

DRUG

Iberdomide

Oral Iberdomide 1.3mg on Days 1 to 21 of a 28-day cycle

DRUG

Iberdomide

Oral Iberdomide 1.6mg on Days 1 to 21 of a 28-day cycle

DRUG

Dexamethasone

Oral dexamethasone 20mg on days 1,2, 4,5,8,9,11,12 of a 21-day cycle from cycles 1-8

DRUG

Daratumumab

Subcutaneous daratumumab 1800mg Cycles 1 to 3 on Days 1, 8, 15 of a 21-day cycle, Cycles 4 to 8 on Day 1 of a 21-day cycle and Cycles 9+ on Day 1 of a 28-day cycle.

Trial Locations (259)

0

Local Institution - 123, Zhengzhou

290

Local Institution - 230, Helsinki

704

Local Institution - 951, Tainan, Taiana

1090

Local Institution - 150, Vienna

1160

Local Institution - 151, Vienna

1200

Local Institution - 174, Brussels

2050

Local Institution - 804, Camperdown

3001

Local Institution - 809, East Melbourne

3004

Local Institution - 801, Melbourne

3065

Local Institution - 800, Fitzroy

3080

Local Institution - 970, Seoul

3100

Local Institution - 156, Sankt Pölten

3168

Local Institution - 802, Clayton

4000

Local Institution - 372, Roskilde

4010

Local Institution - 154, Linz

4575

Local Institution - 813, Birtinya

4814

Local Institution - 812, Douglas

5000

Local Institution - 803, Adelaide

Local Institution - 370, Odense

5020

Local Institution - 153, Salzburg

5042

Local Institution - 806, Bedford Park

5505

Local Institution - 977, Seoul

6005

Local Institution - 807, West Perth

6150

Local Institution - 811, Murdoch

6200

Local Institution - 776, Yenimahalle

7000

Local Institution - 851, Chur

7030

Local Institution - 201, Trondheim

8000

Local Institution - 172, Bruges

9000

Local Institution - 371, Aalborg

10002

Local Institution - 956, Taipei, Zhongzheng Dist.

10005

Local Institution - 501, Cáceres

10016

Local Institution - 691, New York

11217

Local Institution - 950, Taipei

14001

Local Institution - 509, Córdoba

15706

Local Institution - 500, Santiago de Compostela

16132

Local Institution - 414, Genova

18101

Local Institution - 874, Afula

20122

Local Institution - 404, Milan

20246

Local Institution - 300, Hamburg

20521

Local Institution - 231, Turku

20817

Local Institution - 014, Bethesda

22763

Local Institution - 302, Hamburg

23562

Local Institution - 304, Lübeck

24105

Local Institution - 308, Kiel

25437

Local Institution - 271, Helsingborg

26054

Local Institution - 573, Pátrai

27100

Local Institution - 412, Pavia

27310

Local Institution - 772, Gaziantep

27705

Local Institution - 039, Durham

28006

Local Institution - 510, Madrid

28027

Local Institution - 516, Madrid

28034

Local Institution - 504, Madrid

28040

Local Institution - 513, Madrid

28100

Local Institution - 410, Novara

29010

Local Institution - 503, Málaga

30120

Local Institution - 508, Murcia

30322

Local Institution - 018, Atlanta

31008

Local Institution - 514, Pamplona

31059

Local Institution - 457, Toulouse

33011

Local Institution - 506, Oviedo

33100

Local Institution - 406, Udine

33305

Local Institution - 953, Taoyuan

33401

Local Institution - 034, West Palm Beach

33604

Local Institution - 464, Pessac

33705

Local Institution - 028, St. Petersburg

33901

Local Institution - 029, Fort Myers

34899

Local Institution - 777, Pendik

35100

Local Institution - 775, Bornova

35254

Local Institution - 872, Haifa

35340

Local Institution - 771, Balçova

37007

Local Institution - 515, Salamanca

37203

Local Institution - 021, Nashville

37404

Local Institution - 030, Chattanooga

38140

Local Institution - 774, Kayseri

40138

Local Institution - 400, Bologna

40207

Local Institution - 040, Louisville

40447

Local Institution - 952, Taichung

43214

Local Institution - 036, Columbus

44093

Local Institution - 454, Nantes

44109

Local Institution - 037, Cleveland

44195

Local Institution - 008, Cleveland

44600

Local Institution - 183, Guadalajara

45220

Local Institution - 038, Cincinnati

46026

Local Institution - 512, Valencia

50009

Local Institution - 507, Zaragoza

50182

Local Institution - 272, Borås

52621

Local Institution - 873, Tel Litwinsky

53705

Local Institution - 025, Madison

54007

Local Institution - 572, Thessaloniki

54511

Local Institution - 458, Nancy

55239

Local Institution - 773, Samsun

56126

Local Institution - 402, Pisa

57010

Local Institution - 570, Thessaloniki

59037

Local Institution - 451, Lille

60590

Local Institution - 301, Frankfurt am Main

64132

Local Institution - 031, Kansas City

64239

Local Institution - 870, Tel Aviv

69120

Local Institution - 305, Heidelberg

71013

Local Institution - 403, San Giovanni Rotondo FG

71913

Local Institution - 035, Hot Springs

73013

Local Institution - 155, Graz

75013

Local Institution - 456, Paris

75475

Local Institution - 452, Paris

76038

Local Institution - 465, Rouen

77025

Local Institution - 695, Houston

83301

Local Institution - 955, Niao-Sung Hsiang Kaohsiung County

85925

Local Institution - 462, La Roche-sur-Yon

89100

Local Institution - 405, Reggio Calabria

90033

Local Institution - 047, Los Angeles

90220

Local Institution - 232, Oulu

91120

Local Institution - 871, Jerusalem

92663

Local Institution - 684, Newport

92708

Local Institution - 681, Fountain Valley

95100

Local Institution - 463, Argenteuil

95124

Local Institution - 408, Catania

97239

Local Institution - 043, Portland

100020

Local Institution - 121, Chaoyang District

100071

Local Institution - 140, Beijing

100191

Local Institution - 139, Beijing

100730

Local Institution - 138, Beijing

110004

Local Institution - 131, Shenyang

130021

Local Institution - 126, Changchun

150081

Local Institution - 127, Harbin

200025

Local Institution - 132, Shanghai

200032

Local Institution - 130, Shanghai

200434

Local Institution - 142, Shanghai

210029

Local Institution - 134, Nanjing

215006

Local Institution - 124, Suzhu

300020

Local Institution - 133, Tianjin

310006

Local Institution - 128, Hangzhou

Local Institution - 120, Hangzhou, Zhejiang

325000

Local Institution - 144, Wenzhou

330008

Local Institution - 129, Nanchang

400036

Local Institution - 933, Mumbai

407219

Local Institution - 954, Taichung

410013

Local Institution - 141, Changsha

430030

Local Institution - 137, Wuhan

500084

Local Institution - 932, Hyderabad

510030

Local Institution - 135, Guangzhou

510060

Local Institution - 136, Guangzhou

560054

Local Institution - 930, Bangalore

605006

Local Institution - 931, Puducherry

682041

Local Institution - 934, Ernākulam

700014

Local Institution - 935, Kolkata

710000

Local Institution - 125, Xi'an

710004

Local Institution - 143, Xi'an

4093898

Local Institution - 915, Chuo-shi

90703-2679

Local Institution - 641, Cerritos

06511

Local Institution - 033, New Haven

34471-6950

Local Institution - 693, Ocala

33321-2909

Local Institution - 045, Tamarac

33331-3609

Local Institution - 685, Weston

60007-3363

Local Institution - 640, Elk Grove Village

46311-1596

Local Institution - 697, Dyer

71301-3841

Local Institution - 041, Alexandria

70808-4300

Local Institution - 682, Baton Rouge

70809-3675

Local Institution - 027, Baton Rouge

21204-6826

Local Institution - 698, Baltimore

21044-3128

Local Institution - 688, Columbia

02215

Local Institution - 010, Boston

01655

Local Institution - 009, Worcester

55337-6749

Local Institution - 645, Burnsville

59102-6746

Local Institution - 046, Billings

07901

Local Institution - 015, Summit

74146-6236

Local Institution - 680, Tulsa

78705-1165

Local Institution - 687, Austin

23606-3069

Local Institution - 642, Newport News

24014-2419

Local Institution - 643, Roanoke

C1199ABB

Local Institution - 080, Ciudad Autanoma de Buenos Aires

B1894

Local Institution - 083, Villa Elisa

ACT 2605

Local Institution - 808, Garran

80530-010

Local Institution - 056, Curitiba

90460-030

Local Institution - 050, Porto Alegre

90610-000

Local Institution - 058, Porto Alegre

14784-400

Local Institution - 051, Barretos

17210-080

Local Institution - 054, Jaú

05403000

Local Institution - 055, São Paulo

22793-080

Local Institution - 053, Rio de Janeiro

01509-900

Local Institution - 057, São Paulo

04537-080

Local Institution - 052, São Paulo

T2N 4N2

Local Institution - 111, Calgary

T6G 1Z2

Local Institution - 103, Edmonton

V3V 1Z2

Local Institution - 112, Surrey

E2L 3L6

Local Institution - 104, Saint John

A1B3V6

Local Institution - 110, St. John's

B3H 1V7

Local Institution - 101, Halifax

K1H 8L6

Local Institution - 109, Ottawa

G1J 1Z4

Local Institution - 108, Québec

S7N-0W8

Local Institution - 107, Saskatoon

030032

Local Institution - 145, Taiyuan

625 00

Local Institution - 601, Brno

708 52

Local Institution - 600, Ostrava-Poruba

128 08

Local Institution - 602, Prague

264 43

Local Institution - 574, Pátrai

115 28

Local Institution - 571, Athens

T12 DFK4

Local Institution - 752, Cork

D09 V2N0

Local Institution - 750, Dublin

H91 YR71

Local Institution - 751, Galway

00193

Local Institution - 415, Rome

00189

Local Institution - 401, Roma

790-8524

Local Institution - 900, Matsuyama

311-3193

Local Institution - 917, Higashi-Ibaraki-gun

321-0293

Local Institution - 919, Shimotsuga

179-0072

Local Institution - 920, Nerima-ku

142-8666

Local Institution - 918, Shinagawa-ku

030-8553

Local Institution - 912, Aomori

260-8717

Local Institution - 916, Chiba

810-8563

Local Institution - 911, Fukuoka

296-8602

Local Institution - 903, Kamogawa

602-8566

Local Institution - 902, Kyoto

464-8681

Local Institution - 910, Nagoya

467-8602

Local Institution - 901, Nagoya

701-1192

Local Institution - 905, Okayama

545-8585

Local Institution - 907, Osaka

589-8511

Local Institution - 908, Ōsaka-sayama

003-0006

Local Institution - 913, Sapporo

980-8574

Local Institution - 914, Sendai

150-8935

Local Institution - 906, Shibuya-ku

141-8625

Local Institution - 909, Shinagawa-ku, Tokyo

441-8570

Local Institution - 904, Toyohashi

3318 AT

Local Institution - 351, Dordrecht

1081 HV

Local Institution - 354, Amsterdam

2545 CH

Local Institution - 352, The Hague

N-5053

Local Institution - 202, Bergen

0450

Local Institution - 200, Oslo

15-276

Local Institution - 631, Bialystok

30-688

Local Institution - 633, Krakow

33-300

Local Institution - 635, Nowy Sącz

60-569

Local Institution - 634, Poznan

02-781

Local Institution - 630, Warsaw

58-309

Local Institution - 636, Wałbrzych

4200-072

Local Institution - 545, Coimbra

Local Institution - 540, Porto

1099-023

Local Institution - 543, Lisbon

1400-038

Local Institution - 544, Lisbon

4200-319

Local Institution - 541, Porto

700-721

Local Institution - 974, Daegu

410-769

Local Institution - 973, Gyeonggi-do

519-809

Local Institution - 975, Hwasun-gun

06351

Local Institution - 971, Seoul

06591

Local Institution - 976, Seoul

120-752

Local Institution - 972, Seoul

08025

Local Institution - 505, Barcelona

08035

Local Institution - 502, Barcelona

08916

Local Institution - 511, Barcelona

CH-9007

Local Institution - 850, Sankt Gallen

06680

Local Institution - 778, Kavaklıdere

06100

Local Institution - 770, Ankara

NG5 1PB

Local Institution - 702, Nottingham

BT9 7AD

Local Institution - 705, Belfast Northern Ireland

B15 2TH

Local Institution - 700, Birmingham

CT1 3NG

Local Institution - 707, Canterbury Kent

FY3 8NR

Local Institution - 704, Lancashire Blackpool

NW1 2BU

Local Institution - 701, London

SE1 9RT

Local Institution - 709, London

OX3 7LE

Local Institution - 706, Oxford

PO6 3LY

Local Institution - 711, Portsmouth

SM2 5PT

Local Institution - 713, Sutton

WV10 0QP

Local Institution - 708, Wolverhampton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY

NCT04975997 - Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) | Biotech Hunter | Biotech Hunter