A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

246

Participants

Timeline

Start Date

September 16, 2021

Primary Completion Date

November 30, 2026

Study Completion Date

November 30, 2026

Conditions
Relapsed/Refractory Multiple Myeloma
Interventions
DRUG

Sonrotoclax

Administered orally daily

DRUG

Dexamethasone

Once weekly either orally or intravenously

DRUG

Carfilzomib

Administered intravenously weekly

DRUG

Daratumumab

Administered subcutaneously weekly

DRUG

Pomalidomide

Administered orally daily

Trial Locations (94)

2025

RECRUITING

Aotearoa Clinical Trials, Auckland

8036

RECRUITING

Hospital Clinic de Barcelona, Barcelona

10002

RECRUITING

Hospital San Pedro de Alcantara, Cáceres

10060

RECRUITING

Istituto Di Candiolo Irccs, Torino

20141

RECRUITING

Istituto Europeo Di Oncologia, Milan

20251

RECRUITING

Universitatsklinikum Hamburg Eppendorf, Hamburg

29010

RECRUITING

Hospital Universitario Virgen de La Victoria, Málaga

40138

RECRUITING

Policlinico Sorsola Malpighi, Aou Di Bologna, Bologna

41013

RECRUITING

Hospital Universitario Virgen Del Rocio, Seville

44000

RECRUITING

Centre Hospitalier Universitaire Nantes Hotel Dieu, Nantes

47014

RECRUITING

Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori Irst, Meldola

49100

RECRUITING

Rabin Medical Center, Petah Tikva

52074

RECRUITING

Universitaetsklinikum Aachen, Aachen

59000

RECRUITING

Hopital Claude Huriez Chu Lille, Lille

60020

RECRUITING

Azienda Ospedaliera Universitaria Delle Marche, Torrette

68100

RECRUITING

University Hospital of Alexandroupolis, Alexandroupoli

70124

RECRUITING

Azienda Ospedaliera Policlinico Di Bari, Bari

86000

RECRUITING

Chu de Poitiers Site de La Mileterie, Poitiers

94143

RECRUITING

University of California At San Francisco, San Francisco

97080

RECRUITING

Universitatsklinikum Wurzburg, Würzburg

98195

RECRUITING

University of Washington, Seattle

100000

NOT_YET_RECRUITING

Peking University Third Hospital, Beijing

100020

RECRUITING

Beijing Chao Yang Hospital, Beijing

100044

RECRUITING

Peking University Peoples Hospital, Beijing

110001

RECRUITING

The First Hospital of China Medical University, Shenyang

119074

RECRUITING

National University Hospital Singapore, Singapore

200032

RECRUITING

Affiliated Zhongshan Hospital of Fudan University, Shanghai

200434

RECRUITING

Shanghai Fourth Peoples Hospital Affiliated to Tongji University, Shanghai

210008

NOT_YET_RECRUITING

Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School, Nanjing

210029

RECRUITING

Jiangsu Province Hospital, Nanjing

266000

RECRUITING

Qingdao Municipal Hospital, Qingdao

300052

COMPLETED

Tianjin Medical University General Hospital, Tianjin

301617

NOT_YET_RECRUITING

Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciencestuanbo Branch, Tianjin

310003

RECRUITING

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou

332000

RECRUITING

The First Affiliated Hospital of Nanchang University Branch Xianghu, Nanchang

350001

RECRUITING

Fujian Medical University Union Hospital, Fuzhou

361003

COMPLETED

The First Affiliated Hospital of Xiamen University, Xiamen

400030

RECRUITING

Chongqing Cancer Hospital, Chongqing

410013

COMPLETED

Hunan Cancer Hospital, Changsha

430022

RECRUITING

Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan

430030

RECRUITING

Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology, Wuhan

450000

RECRUITING

Henan Cancer Hospital, Zhengzhou

450052

RECRUITING

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

510060

RECRUITING

Sun Yat Sen University Cancer Center, Guangzhou

510080

NOT_YET_RECRUITING

Guangdong Provincial Peoples Hospital, Guangzhou

6423906

RECRUITING

Sourasky Medical Center, Tel Aviv

70390140

RECRUITING

Instituto Dor de Pesquisa E Ensino Distrito Federal, Brasília

35294-0004

RECRUITING

University of Alabama At Birmingham Hospital, Birmingham

91010-3012

RECRUITING

City of Hope National Medical Center, Duarte

92618-2377

RECRUITING

City of Hope At Irvine Lennar, Irvine

33136-2107

RECRUITING

University of Miami, Miami

30322-1013

RECRUITING

Emory University Winship Cancer Center, Atlanta

60637-1443

RECRUITING

University of Chicago Medical Center, Chicago

62781-0001

RECRUITING

Southern Illinois University School of Medicine, Springfield

02114

RECRUITING

Massachusetts General Hospital, Boston

63110-1010

RECRUITING

Washington University School of Medicine, St Louis

07601-1915

RECRUITING

Hackensack University Medical Center, Hackensack

10065-4870

RECRUITING

Weill Cornell Medical College Newyork Presbyterian Hospital, New York

10065-6800

RECRUITING

Memorial Sloan Kettering Cancer Center Mskcc, New York

43210-1240

RECRUITING

The James Cancer Hospital and Solove Research Institute At Ohio State University, Columbus

84112-5550

RECRUITING

Huntsman Cancer Institute, Salt Lake City

53792-0001

RECRUITING

University of Wisconsin Carbone Cancer Center, Madison

53226-1222

RECRUITING

Medical College of Wisconsin, Milwaukee

ACT 2605

RECRUITING

Canberra Hospital, Garran

NSW 2747

RECRUITING

Nepean Hospital, Kingswood

VIC 3168

RECRUITING

Monash Health, Clayton

VIC 3065

RECRUITING

St Vincents Hospital Melbourne, Fitzroy

VIC 3004

RECRUITING

The Alfred Hospital, Melbourne

WA 6000

RECRUITING

Royal Perth Hospital, Perth

70200-730

RECRUITING

Hospital Sirio Libanes Brasilia, Brasília

90110-270

RECRUITING

Centro Gaucho Integrado de Oncologia Hospital Mae de Deus, Porto Alegre

41253-190

RECRUITING

Hospital Sao Rafael (Rede Dor), Salvador

01308-050

RECRUITING

Hospital Sirio Libanes, São Paulo

01409-001

COMPLETED

Hospital Nove de Julho Dasa, São Paulo

01508-010

COMPLETED

Accamargo Cancer Center, São Paulo

04501-000

RECRUITING

Instituto Dor de Pesquisa E Ensino Sao Paulo, São Paulo

04537-080

COMPLETED

Clinica Sao Germano, São Paulo

05653-120

RECRUITING

Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo

T6G 1Z2

RECRUITING

Cross Cancer Institute, Edmonton

V5Z 4E6

RECRUITING

British Columbia Cancer Agency the Vancouver Centre, Vancouver

M5G 2M9

RECRUITING

Princess Margaret Cancer Centre, Toronto

050000

COMPLETED

The Second Hospital of Hebei Medical University, Shijiazhuang

01307

RECRUITING

Universitatsklinikum Carl Gustav Carus An Der Technischen Universitat Dresden, Dresden

115 28

RECRUITING

General Hospital of Athens Alexandra, Athens

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli, Roma

06351

RECRUITING

Samsung Medical Center, GangnamGu

06591

RECRUITING

The Catholic University of Korea, Seoul St Marys Hospital, SeochoGu

03722

RECRUITING

Severance Hospital Yonsei University Health System, SeodaemunGu

03080

RECRUITING

Seoul National University Hospital, Seoul

05505

RECRUITING

Asan Medical Center, SongpaGu

OX3 7LE

RECRUITING

Churchill Hospital Oxford University Hospital Nhs Trust, Headington

NW1 2PG

RECRUITING

University College Hospital, London

SM2 5PT

RECRUITING

Royal Marsden Nhs Foundation Royal Marsden Hospital, Sutton

TR1 3LJ

RECRUITING

Royal Cornwall Hospitalsnhs Trust, Truro

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY

NCT04973605 - A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma | Biotech Hunter | Biotech Hunter