A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)

PHASE1RecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

June 17, 2022

Primary Completion Date

October 30, 2026

Study Completion Date

October 29, 2027

Conditions
B-Cell Non-Hodgkin LymphomaRelapsed B-Cell Non-Hodgkin LymphomaRefractory B-Cell Non-Hodgkin Lymphoma
Interventions
DRUG

Loncastuximab Tesirine

Intravenous (IV) infusion

DRUG

Polatuzumab Vedotin

IV infusion

DRUG

Glofitamab

IV infusion

DRUG

Mosunetuzumab

Subcutaneous (SC) injection

DRUG

Obinutuzumab

IV infusion

Trial Locations (42)

9000

RECRUITING

Universitair Ziekenhuis Gent, Ghent

10027

RECRUITING

Columbia University Irving Medical Center, New York

15224

RECRUITING

Allegheny Health Network - West Penn Hospital, Pittsburgh

19104

RECRUITING

Penn Medicine - Perelman Center for Advanced Medicine, Philadelphia

20141

RECRUITING

Istituto Europeo di Oncologia, Milan

22031

COMPLETED

NEXT Virginia (Virginia Cancer Specialists), Fairfax

22903

RECRUITING

Emily Couric Clinical Cancer Center, Charlottesville

24127

RECRUITING

Azienda Socio Sanitaria Territoriale (ASST) Papa Giovanni XXIII, Bergamo

25123

RECRUITING

Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia, Brescia

28007

RECRUITING

Hospital General Universitario Gregorio Marañón, Madrid

28034

RECRUITING

Hospital Universitario Ramón y Cajal, Madrid

29425

ACTIVE_NOT_RECRUITING

Hollings Cancer Center, Charleston

30322

RECRUITING

Winship Cancer Institute of Emory University, Atlanta

30342

RECRUITING

The Blood and Marrow Transplant Group of Georgia, Atlanta

33028

RECRUITING

Memorial Cancer Institute - Memorial Hospital West, Pembroke Pines

33136

RECRUITING

Sylvester Comprehensive Cancer Center, Miami

33176

RECRUITING

Miami Cancer Institute, Miami

37007

RECRUITING

Complejo Asistencial Universitario de Salamanca - Hospital Clínico, Salamanca

37203

RECRUITING

Greco-Hainsworth Tennessee Oncology Centers for Research (GHCR), Nashville

40138

RECRUITING

Centro di Ricerche Cliniche - IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna

44195

RECRUITING

Cleveland Clinic Main Campus, Cleveland

46026

RECRUITING

Hospital Universitari i Politècnic La Fe, Valencia

50309

RECRUITING

Mission Cancer + Blood - Mission Cancer Foundation, Des Moines

53226

RECRUITING

Froedtert & Medical College of Wisconsin, Milwaukee

55455

RECRUITING

University of Minnesota, Minneapolis

57105

WITHDRAWN

Avera Cancer Institute, Sioux Falls

75246

RECRUITING

Baylor University Medical Center, Dallas

84112

RECRUITING

Huntsman Cancer Institute, Salt Lake City

92103

RECRUITING

Scripps Health - Prebys Cancer Center, San Diego

93611

RECRUITING

University of California San Francisco - Fresno Center for Medical Education and Research, Clovis

97239

RECRUITING

Oregon Health and Science University, Portland

02215

RECRUITING

Beth Israel Deaconess Medical Center, Boston

RECRUITING

Dana-Farber Cancer Institute, Boston

02903

RECRUITING

Brown University Health - Rhode Island Hospital, Providence

B-5530

RECRUITING

Centre Hospitalier Universitaire Universite Catholique de Louvain - Site Godinne, Yvoir

625 00

RECRUITING

Fakultni Nemocnice Brno, Brno

708 52

RECRUITING

Fakultni nemocnice Ostrava, Ostrava

100 34

RECRUITING

Fakultní Nemocnice Královské Vinohrady, Prague

150 06

RECRUITING

Fakultni nemocnice v Motole, Prague

08908

RECRUITING

Institut Català d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet), Barcelona

NW1 2PG

COMPLETED

University College London Hospitals NHS Foundation Trust, London

OX3 7LE

COMPLETED

Oxford University Hospitals NHS Foundation Trust, Oxford

Sponsors
All Listed Sponsors
lead

ADC Therapeutics S.A.

INDUSTRY