Efficacy and Safety of KBP-5074 in Uncontrolled Hypertension and Moderate or Severe Chronic Kidney Disease (CKD)

PHASE3TerminatedINTERVENTIONAL
Enrollment

652

Participants

Timeline

Start Date

November 5, 2021

Primary Completion Date

January 30, 2024

Study Completion Date

July 10, 2024

Conditions
Chronic Kidney Diseases
Interventions
DRUG

Placebo

Participants will orally receive placebo matching to KBP-5074 tablets QD.

DRUG

KBP-5074

Participants will orally receive KBP-5074 tablets, from 0.25 mg to a maximum dose of 0.5-mg QD.

Trial Locations (215)

110

Taipei Medical University - Shuang Ho Hospital - Nephrology, Taipei

406

China Medical University Hospital - Nephrology - Taichung, Taichung

1083

Semmelweis Egyetem, Budapest

1113

DCC 22 - Sofia, Sofia

1204

Jahn Ferenc Dél-Pesti Kórház és Rendelőintézet, Budapest

1233

5 th MHAT, Sofia

1400

Ministry of Defence of Georgia LEPL Giorgi Abramishvili Military Hospital, Gori

1407

Medical Center Excelsior, Sofia

1431

UMHAT St. Ekaterina, Sofia

1510

Medical Center Hera EOOD, Sofia

1612

Comac Medical Ltd, Sofia

1784

Medical Center ''Synexus Sofia'' EOOD, Sofia

2143

Kistarcsai Flor Ferenc Korhaz, Kistarcsa Hungary

2193

Charlotte Maxeke Johannesburg Hospital, Soweto

2250

Renal Research, Gosford

3000

Ltd Marnecor, Marneuli

3084

Austin Hospital, Heidelberg

3400

Medical Center Hera EOOD, Montana

3530

IPR Hungary Kft., Miskolc

4001

Office of Gulam Hoosain Vally, Durban

4002

UMHAT Kaspela, Plovdiv

5000

Royal Adelaide Hospital, Adelaide

5300

Mhat Dr.Tota Venkova, Gabrovo

6000

University Hospital of Active Treatment Prof. Stoyan Kirkovich, Stara Zagora

"LTD High technology hospital MEDCENTER", Batumi

6010

"JSC Evex Hospitals'", Batumi

6273

Gangnam Severance Hospital, Yonsei University Health System - Internal Medicine, Seoul

6351

Samsung Medical Center - Nephrology, Seoul

6591

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

6725

Sonocor Egészségügyi Szolgáltató Kft., Szeged

7012

"Medical Center Teodora", Rousse

7130

Dr J.M. Engelbrecht Trial Site, Somerset West

7530

Tiervlei Trial Centre, Bellville, Cape Town

7624

Coromed-Smo Kft., Pécs

TaNa Med Kft, Mosonmagyaróvár

8003

Hospital del Mar, Barcelona

8023

Hospital Quironsalud Barcelona, Barcelona

8035

Hospital de La Santa Creu i Sant Pau, Barcelona

8230

DRC Gyógyszervizsgáló Központ Kft., Balatonfüred

9002

"MHATSv.Anna-VarnaAD", Varna

9301

Iatros International, Bloemfontein

10000

University Hospital Centre Zagreb, Zagreb

10002

National Taiwan University Hospital - Nephrology, Taipei

10117

Charité- Universitätsmedizin Berlin, Berlin

10444

National Health Insurance Service Ilsan Hospital - Nephrology, Goyang-si

11000

Military Medical Academy, Belgrade

Zvezdara University Medical Center, Belgrade

11080

Clinical Hospital Centre Zemun, Zemun

11385

Mattoo & Bhat Medical Associates, PC, Ridgewood

11432

NYC Health + Hospitals / Queens - Diabetes Center of Excellence, Jamaica

12203

Charité - Universitätsmedizin Berlin, Berlin

15586

Hospital Raja Perempuan Zainab II, Kota Bharu

16100

Nazareth Hospital EMMS, Nazareth

18000

Clinical Centre Nis, Niš

18014

Hospital Universitario Virgen de las Nieves, Granada

20954

Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie, Lublin

21000

University Hospital Center Split, Split

Clinical Center Vojvodina, Novi Sad

23219

Dominion Medical Associates, Inc., Richmond

23502

Davita Norfolk Square, Norfolk

23538

DaVita Clinical Research Germany GmbH, Düsseldorf

27834

Physicians East, PA, Greenville

27880

Hospital público da Mariña, Burela de Cabo

Hospital Ribera Polusa, Burela de Cabo

28040

Hospital Universitario Fundación Jiménez Díaz, Madrid

28546

Eastern Nephrology Associates - Jacksonville, Jacksonville

30342

Fides Clinical Research, Atlanta

30450

Hospital Raja Permaisuri Bainun, Ipoh

30625

Medizinische Hochschule Hannover, Hanover

30904

Southeastern Clinical Research Institute, LLC, Augusta

32100

Opca bolnica Vinkovci, Vinkovci

32400

Hospital Seri Manjung, Seri Manjung

32808

Omega Research Orlando, LLC, Orlando

33014

Inpatient Research Clinic, LLC, Miami Lakes

33126

LCC Medical Research, Miami

33144

Oceane 7 Medical&Research Center, Inc., Miami

33155

Allied Biomedical Research Institute, Miami

33166

South Florida Research Phase I-Iv, Inc., Miami

33305

Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital - Nephrology, Taoyuan District

33603

Genesis Clinical Research, Tampa

33604

Santos Research Center CORP, Tampa

34104

New Generation Of Medical Research, Naples

34208

Synergy Healthcare, Bradenton

34471

Sarkis Clinical, Ocala

35015

Chungnam National University Hospital - Nephrology, Daejeon

35805

Apogee Clinical Research, LLC, Huntsville

36535

G & L Research, LLC, Foley

40705

Taichung Veterans General Hospital - Nephrology, Taichung

44137

Diabeteszentrum DO, Dortmund

45439

Providence Health Partners-Center for Clinical Research, Dayton

46014

Consorcio Hospital General Universitario de Valencia, Valencia

46026

Hospital Universitario Y Politécnico La Fe, Valencia

49100

Rabin Medical Center, Petah Tikwa

50004

The Second Hospital of Hebei Medical University, Shijiazhuang

50586

Hospital Kuala Lumpur, Kuala Lumpur

53142

Clinical Investigation Specialists, Kenosha

53226

Milwaukee Nephrologists, SC (Rich), Wauwatosa

55131

Universitätsklinikum Mainz, Mainz

59100

University Malaya Medical Centre, Kuala Lumpur

60031

Clinical Investigation Specialists, Inc., Gurney

63042

Healthcare Research Network, Hazelwood

71000

Clinical Center University of Sarajevo, Sarajevo

72460

General Hospital Tesanj, Tešanj

73300

The University Hospital Foca, Foča

77004

DaVita Clinical Research Houston, Houston

77099

Pioneer Research Solutions, Inc., Houston

77384

Kidney Specialists of North Houston, PLLC, The Woodlands

78000

Univerzitetski klinicki centar Republike Srpske - Internal Medicine, Nephrology, Banja Luka

78052

Nephrologisches Zentrum Villingen-Schwenningen, Villingen-Schwenningen

78251

DaVita Clinical Research, San Antonio

78400

General Hospital Gradiska, Gradiška

78503

Gamma Clinical Research Institute, Austin

79925

Davita Clinical Research El Paso, El Paso

79935

Kidney Consultants of El Paso, P.A., El Paso

85210

Aventiv Research, Inc, Mesa

89101

General hospital Trebinje - Gastroenterology, Trebinje

89128

DaVita Clinical Research (Nevada), Las Vegas

90127

Synexus Polska Sp. z. o.o., Lodz

90280

United Clinical Research and Innovations, South Gate

91324

Amicis Research Center (Valencia), Granada Hills

91325

Renal Consultants Medical Group - Granada Hills, Northridge

91344

Amicis Research Center, Granada Hills

92392

Desert Cities Dialysis - Amethyst, Victorville

92395

Kidney and Hypertension Center, Victorville

93534

Amicis Research Center, Lancaster

100020

Beijing Chao-Yang Hospital, Capital Medical University, Beijing

100029

Beijing An Zhen Hospital, Capital Medical University, Beijing

China-Japan Friendship Hospital, Beijing

100034

Peking University First Hospital, Beijing

100730

Beijing Hospital, Beijing

200000

Shanghai General Hospital, Shanghai

200233

Shanghai Sixth People's Hospital, Shanghai

210029

Jiangsu Province Hospital/ The First Affiliated Hospital with Nanjing Medical University, Nanjing

214023

Wuxi People's Hospital, Wuxi

264000

Yantai Yuhuangding Hospital(Base Cpmpus), Yantai

300052

Tianjin Medical University General Hospital, Tianjin

321000

Jinhua Central Hospital, Jinhua

325000

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

350005

The First Affiliated Hospital of Fujian Medical University, Fuzhou

361003

The First Affiliated Hospital of Xiamen University, Xiamen

361004

Zhongshan Hospital Xiamen University, Xiamen

400038

The Southwest Hospital of AMU, Chongqing

410011

The Second Xiangya Hospital of Central South University, Changsha

410013

The Third Xiangya Hospital of Central South University, Changsha

510080

Guangdong Provincial People's Hospital, Guangzhou

510180

Guangzhou First People's Hospital - Nephrology, Guangzhou

510655

The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou

530021

The People's Hospital of Guangxi Zhuang Autonomous Region- Nephrology, Nanning

550004

The Affliated Hospital of Guizhou Medical University, Guiyang

610072

Sichuan Academy of Medical Sciences, Chengdu

710061

The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an

750004

General Hospital of Ningxia Medical University, Yinchuan

90211-2285

National Heart Institute, Beverly Hills

95687-3557

Solano Kidney Care, Vacaville

06002

Davita Clinical Research-Hartford, Bloomfield

33032-8225

Homestead Associates in Research, Inc, Miami

33126-3422

Total Research Group, Miami

Clinical Center Kragujevac, Kragujevac

33014-5602

San Marcus Research Clinic, Inc., Miami Lakes

31904-3650

Columbus Associates LLC, Columbus

31201-6863

Central Georgia Kidney Specialists, Macon

02114

Massachusetts General Hospital (MGH) - Renal Associates Clinic, Boston

55435-2129

InterMed Consultants, Edina

64111-5964

Clinical Research Consultants, Kansas City

63136-6111

St. Louis Heart and Vascular, P.C. (SLHV) - Christian Hospital Office, St Louis

89102-1682

Healor Primary Care /CCT Research, Las Vegas

10461-1900

Albert Einstein's College of Medicine, The Bronx

10461-2710

Kidney Medical Associates, PLLC, The Bronx

28801-4104

Mountain Kidney & Hypertension Associates (MKHA), P.A - Asheville, Asheville

28562-5200

Eastern Nephrology Associates - New Bern, New Bern

27609-7511

North Carolina Nephrology P.A., Raleigh

27103-7108

Brookview Hills Research Associates, LLC, Winston-Salem

29203-6476

Columbia Nephrology Associates, PA, Columbia

37923-3624

Knoxville Kidney Center, PLLC, Knoxville

78212-4738

Clinical Advancement Center, PLLC, San Antonio

78229-3342

Urology San Antonio - North Central, San Antonio

M4C 5T2

Dr. Stephen S. Chow Medicine Professional Corporation, Toronto

N2T 0C1

Clinical Research Solutions Incorporated, Waterloo

Unknown

The First Affiliated Hospital of Zhengzhou University (East Compus), Zhengzhou

The Central Hospital of Wuhan, Wuhan

Shandong Provincial Hospital, Jinan

The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou

Zhejiang Hospital, Hangzhou

Zhejiang Provincial People's Hospital, Hangzhou

Queen Mary Hospital - Medicine, Hong Kong

Tung Wah Hospital, Hong Kong

Dace Teterovska - Doctor's Practice, Ogre

P.Stradina Clinical University Hospital, Riga

MSB General hospital - Clinical Research Center, Belgrade

014010

The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou

149 00

Nefrologie s.r.o., Prague

674 01

Nemocnice Trebic, p.o., Třebíč

140 21

IKEM, Prague

160 00

Alaron s.r.o., Prague

0102

Aleksandre Aladashvili Clinic LLC, Tbilisi

0112

LTD Israel-Georgian Medical Research Clinic Helsicore, Tbilisi

0114

"Pineo Medical EcosystemLTD", Tbilisi

0119

JSC German Clinic, Tbilisi

0144

National Center of Urology Named after Laur Managadze, Tbilisi

0159

Bokhua Memorial Cardiovascular Centre, Tbilisi

Emergency Cardiology Center named by acad. G. Chapidze, Tbilisi

"J.S.C.K.Eristavi National Center of Experimental and Clinical Surgery", Tbilisi

07747

Universitätsklinikum Jena, Jena

H-3000

BKS Research, Hatvan

H-7400

Somogy Megyei Kaposi Mór Oktató Kórház, Kaposvár

LT-49449

Saules seimos medicinos centras, Kaunas

86-300

NZOZ Euromedica Sp. z o.o., Grudziądz

94-074

Prywatny Gabinet Lekarski i Wizyty Lekarskie Jan Ruxer, Lodz

40-040

Synexus Polska Sp. z o.o., Katowice

92-213

SP ZOZ Centralny Szpital Kliniczny UM w Lodzi, Lodz

60-702

Synexus Polska Sp. z o.o., Poznan

02-672

Synexus Polska Sp. z o.o., Warsaw

51-685

WroMedica I. Bielicka, A. Strzalkowska s.c., Wroclaw

03080

Seoul National University Hospital - Nephrology, Jongno-gu

08025

FUNDACION PUIGVERT - Nephrology Department, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

KBP Biosciences

INDUSTRY

NCT04968184 - Efficacy and Safety of KBP-5074 in Uncontrolled Hypertension and Moderate or Severe Chronic Kidney Disease (CKD) | Biotech Hunter | Biotech Hunter