Understanding Host-pathogen Interaction in the Respiratory Mucosa During Pregnancy

Active, not recruitingOBSERVATIONAL
Enrollment

30

Participants

Timeline

Start Date

March 2, 2022

Primary Completion Date

September 27, 2023

Study Completion Date

September 30, 2025

Conditions
Pregnancy RelatedInnate Inflammatory Response
Interventions
OTHER

Nasal brush sampling

Nasal brush samples will be collected from the inferior turbinate using standardized techniques after local anesthetic application. After clearing the mucus from the nasal cavity by asking the patient to blow their nostrils twice followed by local anesthetic spray application, nasal brush samples will be collected from the inferior turbinate of each nostril with dedicated soft cytology brushes and pooled together for molecular biological experiments. Simultaneously, 10 mL of peripheral blood will be collected for immunophenotyping.

Trial Locations (1)

63110

Washington University in St. Louis, St Louis

All Listed Sponsors
lead

Washington University School of Medicine

OTHER