Treatment Combination of Durvalumab, Tremelimumab and Enfortumab Vedotin or Durvalumab and Enfortumab Vedotin in Patients With Muscle Invasive Bladder Cancer Ineligible to Cisplatin or Who Refuse Cisplatin

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

712

Participants

Timeline

Start Date

August 5, 2021

Primary Completion Date

April 30, 2026

Study Completion Date

September 8, 2028

Conditions
Muscle Invasive Bladder Cancer
Interventions
DRUG

Durvalumab

Anti- PD-L1 Antibody

DRUG

Tremelimumab

Human IgG2 mAb

DRUG

Enfortumab Vedotin

Nectin-4-directed antibody and microtubule inhibitor conjugate

PROCEDURE

Radical Cystectomy

For cisplatin-ineligible or cisplatin-refusal patients

Trial Locations (202)

710

Research Site, Tainan City

1020

Research Site, Vienna

1090

Research Site, Vienna

2700

Research Site, Wiener Neustadt

3500

Research Site, Krems

4020

Research Site, Linz

4710

Research Site, Braga

5000

Research Site, Ankara

5020

Research Site, Salzburg

8036

Research Site, Graz

10040

Research Site, New York

10300

Research Site, Dusit

10330

Research Site, Bangkok

10408

Research Site, Goyang-si

11000

Research Site, Belgrade

11219

Research Site, Brooklyn

11528

Research Site, Athens

12462

Research Site, Athens

13210

Research Site, Syracuse

13273

Research Site, Marseille

13385

Research Site, Marseille

13620

Research Site, Seongnam-si

14263

Research Site, Buffalo

15125

Research Site, Maroussi, Athens

15212

Research Site, Pittsburgh

17033

Research Site, Hershey

20010

Research Site, Washington D.C.

20132

Research Site, Milan

20141

Research Site, Milan

21204

Research Site, Kamenitz

22030

Research Site, Edirne

23502

Research Site, Norfolk

28018

Research Site, Colima

28033

Research Site, Madrid

28040

Research Site, Madrid

28046

Research Site, Madrid

30625

Research Site, Hanover

31008

Research Site, Pamplona

31096

Research Site, Haifa

31130

Research Site, Quint-Fonsegrives

32098

Research Site, Istanbul

33611

Research Site, Bielefeld

33901

Research Site, Fort Myers

34070

Research Site, Montpellier

34722

Research Site, Istanbul

35016

Research Site, Las Palmas de Gran Canaria

35128

Research Site, Padua

35392

Research Site, Giessen

35575

Research Site, Karşıyaka

37124

Research Site, Verona

37932

Research Site, Knoxville

38100

Research Site, Hadera

39120

Research Site, Magdeburg

39213

Research Site, Jackson

40207

Research Site, Louisville

40225

Research Site, Düsseldorf

40447

Research Site, Taichung

40705

Research Site, Taichung

41009

Research Site, Seville

42100

Research Site, Reggio Emilia

42270

Research Site, Saint-Priez En Jarez

44625

Research Site, Herne

44791

Research Site, Bochum

46250

Research Site, Indianapolis

47014

Research Site, Meldola

47392

Research Site, Busan

48114

Research Site, Brighton

48149

Research Site, Münster

50134

Research Site, Florence

50937

Research Site, Cologne

52242

Research Site, Iowa City

54519

Research Site, Vandœuvre-lès-Nancy

55131

Research Site, Mainz

59000

Research Site, Lille

60153

Research Site, Maywood

63011

Research Site, Clermont-Ferrand

64000

Research Site, Monterrey

64100

Research Site, Bayonne

64239

Research Site, Tel Aviv

67091

Research Site, Strasbourg

68167

Research Site, Mannheim

69008

Research Site, Lyon

69495

Research Site, Pierre-Bénite

70124

Research Site, Bari

70403

Research Site, Tainan City

72766

Research Site, Reutlingen

73039

Research Site, Tricase

75063

Research Site, Irving

75246

Research Site, Dallas

76104

Research Site, Fort Worth

77030

Research Site, Houston

78731

Research Site, Austin

80078

Research Site, Pozzuoli

80090

Research Site, Amiens

81377

Research Site, München

83814

Research Site, Coeur d'Alene

89075

Research Site, Ulm

89102

Research Site, Las Vegas

90110

Research Site, Songkhla

90404

Research Site, Santa Monica

92151

Research Site, Suresnes

92868

Research Site, Orange

93053

Research Site, Regensburg

97239

Research Site, Portland

99208

Research Site, Spokane

100000

Research Site, Hanoi

Research Site, Hà Nội

530000

Research Site, Huế

700000

Research Site, Ho Chi Minh City

7500653

Research Site, Santiago

7500921

Research Site, Santiago

9103102

Research Site, Jerusalem

9112001

Research Site, Jerusalem

91350200

Research Site, Porto Alegre

06510

Research Site, New Haven

04074

Research Site, Scarborough

02111

Research Site, Boston

07663

Research Site, Saddle Brook

C1431FWO

Research Site, Buenos Aires

C1426ANZ

Research Site, CABA

C1280AEB

Research Site, Ciudad de Buenos Aires

C1419AHL

Research Site, Ciudad de Buenos Aires

B2700CPM

Research Site, Pergamino

B1629AHJ

Research Site, Pilar

14784-400

Research Site, Barretos

81520-060

Research Site, Curitiba

60135-237

Research Site, Fortaleza

90035-001

Research Site, Porto Alegre

90035-003

Research Site, Porto Alegre

90610-000

Research Site, Porto Alegre

22250-905

Research Site, Rio de Janeiro

97015-450

Research Site, Santa Maria

09060-650

Research Site, Santo André

01246-000

Research Site, São Paulo

01323-903

Research Site, São Paulo

03162-065

Research Site, Săo Paulo

38408-150

Research Site, Uberlândia

V2S 3N5

Research Site, Abbotsford

M4N 3M5

Research Site, Toronto

G1R 2J6

Research Site, Québec

J1H 5N4

Research Site, Sherbrooke

06189

Research Site, Nice

00000

Research Site, Shatin

00128

Research Site, Roma

00137

Research Site, Roma

00144

Research Site, Roma

05100

Research Site, Terni

113-8431

Research Site, Bunkyō City

811-1395

Research Site, Fukuoka

431-3192

Research Site, Hamamatsu

272-8516

Research Site, Ichikawa-shi

920-8641

Research Site, Kanazawa

634-8522

Research Site, Kashihara-shi

216-8511

Research Site, Kawasaki-shi

761-0793

Research Site, Kita-gun

650-0017

Research Site, Kobe

860-0008

Research Site, Kumamoto

791-0288

Research Site, Matsuyama

889-1692

Research Site, Miyazaki

951-8566

Research Site, Niigata

700-8558

Research Site, Okayama

541-8567

Research Site, Osaka

545-8586

Research Site, Osaka

589-8511

Research Site, Osakasayama-shi

930-0194

Research Site, Toyama

305-8576

Research Site, Tsukuba

241-8515

Research Site, Yokohama

6815 AD

Research Site, Arnhem

4818 CK

Research Site, Breda

9713 GZ

Research Site, Groningen

2134 TM

Research Site, Hoofddorp

2333 ZA

Research Site, Leiden

3508 GA

Research Site, Utrecht

80-214

Research Site, Gdansk

67-106

Research Site, Nowa Sól

60-185

Research Site, Skórzewo

02-781

Research Site, Warsaw

3000-075

Research Site, Coimbra

8000-386

Research Site, Faro

1169-050

Research Site, Lisbon

1350-352

Research Site, Lisbon

1500-458

Research Site, Lisbon

1500-650

Research Site, Lisbon

1649-035

Research Site, Lisbon

405-760

Research Site, Incheon

02841

Research Site, Seoul

03080

Research Site, Seoul

06351

Research Site, Seoul

06591

Research Site, Seoul

07985

Research Site, Seoul

08035

Research Site, Barcelona

08036

Research Site, Barcelona

08041

Research Site, Barcelona

08208

Research Site, Barcelona

08907

Research Site, L'Hospitalet de Llobregat

01060

Research Site, Adana

06560

Research Site, Ankara

06620

Research Site, Ankara

Unknown

Research Site, Ankara

07025

Research Site, Antalya

EC1A 7BE

Research Site, London

NW1 2PG

Research Site, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY