Study of Pembrolizumab (MK-3475) Subcutaneous (SC) Versus Pembrolizumab Intravenous (IV) Administered With Platinum Doublet Chemotherapy in Participants With Metastatic Squamous or Nonsquamous Non-Small Cell Lung Cancer (NSCLC) (MK-3475-A86)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

531

Participants

Timeline

Start Date

August 5, 2021

Primary Completion Date

April 4, 2023

Study Completion Date

October 14, 2026

Conditions
Non-Small Cell Lung Cancer
Interventions
BIOLOGICAL

Pembrolizumab SC

SC injection

BIOLOGICAL

Pembrolizumab IV

IV injection

DRUG

Paclitaxel

IV injection

DRUG

Nab-Paclitaxel

IV infusion

DRUG

Carboplatin

IV infusion

DRUG

Cisplatin

IV infusion

DRUG

Pemetrexed

IV infusion

Trial Locations (126)

300

National Taiwan University Hospital Hsin-Chu Branch ( Site 2103), Hsinchu

333

Chang Gung Medical Foundation-Linkou Branch ( Site 2102), Taoyuan District

704

National Cheng Kung University Hospital ( Site 2105), Tainan City

807

Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 2107), Kaohsiung City

1083

Semmelweis University-Pulmonológiai Klinika ( Site 1114), Budapest

1121

Orszagos Koranyi Pulmonologiai Intezet ( Site 1104), Budapest

2013

Chris Hani Baragwanath Academic Hospital-Wits Clinical Research Bara ( Site 1513), Soweto

2045

Tudogyogyintezet Torokbalint ( Site 1105), Törökbálint

2193

Wits Clinical Research ( Site 1510), Johannesburg

2196

Sandton Oncology Medical Group PTY LTD ( Site 1505), Sandton

4001

The Oncology Centre ( Site 1507), Durban

5000

Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 1103), Szolnok

6000

Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 1106), Kecskemét

7570

Cape Town Oncology Trials Pty Ltd ( Site 1500), Kraaifontein

8582

Veszprem Megyei Tudogyogyintezet ( Site 1108), Farkasgyepű

8900

Zala Megyei Szent Rafael Korhaz ( Site 1111), Zalagerszeg

9023

Petz Aladar Megyei Oktato Korhaz ( Site 1110), Győr

10048

National Taiwan University Hospital ( Site 2101), Taipei

10461

Montefiore Medical Center [Bronx, NY] ( Site 0040), The Bronx

11217

Taipei Veterans General Hospital ( Site 2106), Taipei

13007

Clínica Peruano-Americana de Trujillo ( Site 0701), Trujillo

15036

Oncosalud ( Site 0706), Lima

Clinica Internacional Sede San Borja ( Site 0705), Lima

15038

Instituto Nacional de Enfermedades Neoplasicas ( Site 0703), Lima

15102

Hospital Nacional Cayetano Heredia ( Site 0700), Lima

21005

Hospital Juan Ramon Jimenez ( Site 1602), Huelva

24060

Oncology & Hematology Assoc. SW Virginia, Inc., DBA Blue Ridge Cancer Care ( Site 0100), Blacksburg

25011

Ukrainian Center of Tomotherapy ( Site 1807), Kropyvnytskyi

26506

West Virginia University ( Site 0056), Morgantown

27003

Hospital Universitario Lucus Augusti ( Site 1603), Lugo

28046

Hospital Universitario La Paz ( Site 1601), Madrid

32804

Advent Health ( Site 0013), Orlando

33021

Memorial Regional Hospital-Memorial Cancer Institute ( Site 0104), Hollywood

33308

Holy Cross Hospital ( Site 0017), Fort Lauderdale

34298

Institut Regional du Cancer de Montpellier - ICM ( Site 1003), Montpellier

34722

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1701), Istanbul

35001

Hospital Insular de Gran Canaria-Oncology ( Site 1604), Las Palmas de Gran Canaria

35015

Chungnam National University Hospital ( Site 2002), Daejeon

35040

Ege Universitesi Tip Fakultesi Hastanesi ( Site 1703), Izmir

37203

Tennessee Oncology ( Site 0051), Nashville

37920

The University of Tennessee Medical Center ( Site 0050), Knoxville

39617

Kremenchuk Regional Oncology Center ( Site 1811), Kremenchuk

40503

Baptist Health Lexington ( Site 0099), Lexington

44280

Inonu Universitesi Turgut Ozal Tip Merkezi ( Site 1707), Malatya

44800

Hopital Guillaume & Rene Laennec ( Site 1007), Saint-Herblain

46804

Fort Wayne Medical Oncology and Hematology ( Site 0101), Fort Wayne

50000

Medical Center Mriya Med-Service ( Site 1805), Kryvyi Rih

50006

Changhua Christian Hospital ( Site 2104), Changhua

58128

Chonnam National University Hwasun Hospital-Pulmonology ( Site 2000), Hwasun

59102

St. Vincent Frontier Cancer Center ( Site 0058), Billings

61070

Communal non profit enterprise Regional Clinical Oncology Center ( Site 1806), Kharkiv

64000

Centre Hospitalier de Pau ( Site 1016), Pau

64111

St Luke's Hospital - Kansas City ( Site 0033), Kansas City

65025

Municipal non-profit enterprise'Odesa Regional Clinical Hosp-Thoracic surgery department. ( Site 181, Odesa

67091

Nouvel Hôpital Civil (NHC) ( Site 1018), Strasbourg

72401

St. Bernards Medical Center ( Site 0103), Jonesboro

75014

Hopital Cochin ( Site 1002), Paris

76031

CHU de Rouen ( Site 1013), Rouen

77030

Oncology Consultants, PA ( Site 0052), Houston

77090

Millennium Physicians - Oncology ( Site 0097), Houston

87042

CHU Limoges CHU Dupuytren ( Site 1011), Limoges

90602

PIH Health Hematology Medical Oncology ( Site 0106), Whittier

90720

Cancer Blood and Specialty Clinic ( Site 0105), Los Alamitos

92150

Hôpital Foch ( Site 1019), Suresnes

92835

St Joseph Heritage Healthcare-Oncology ( Site 0102), Fullerton

97448

Centre Hospitalier Sud Réunion ( Site 1020), Saint-Pierre

100337

Spitalul Municipal Ploiesti ( Site 1308), Ploieşti

190103

SPBU Clinic of Advanced medical technologies n.a. N. I. Pirogov ( Site 1406), Saint Petersburg

197758

National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 1407), Saint Petersburg

Saint-Petersburg Scientific-Practical Center of Specialized Kinds of Medical Care (o) ( Site 1424), Saint Petersburg

198255

SPb SBHI City Clinical Oncological Dispensary ( Site 1409), Saint Petersburg

200347

S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 1304), Craiova

200385

Centrul de Oncologie Oncolab-Medical Oncology ( Site 1312), Craiova

300239

Policlinica Oncomed SRL ( Site 1302), Timișoara

400015

Cardiomed SRL Cluj-Napoca ( Site 1313), Cluj-Napoca

Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 1303), Cluj-Napoca

407280

SC Radiotherapy Center Cluj SRL ( Site 1307), Comuna Floresti

420029

Republican Clinical Oncology Dispensary-Chemotherapy #1 ( Site 1425), Kazan'

4701192

Fujita Health University Hospital ( Site 3007), Toyoake

7008558

Okayama University Hospital ( Site 3012), Okayama

89201260

Instituto Joinvilense de Hematologia e Oncologia ( Site 0308), Joinville

29308-065

HOSPITAL EVANGÉLICO DE CACHOEIRO DE ITAPEMIRIM ( Site 0307), Cachoeiro de Itapemirim

99010-080

Hospital Sao Vicente de Paulo ( Site 0311), Passo Fundo

15090-000

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto ( Site 0305), São José do Rio Preto

04014-002

Núcleo de Pesquisa Clínica da Rede São Camilo ( Site 0304), São Paulo

01010

Centro de Investigaciones Clinicas de Latinoamerica S.A. - CELAN ( Site 0602), Guatemala City

Clinica Privada Dr. Rixci Ramirez ( Site 0601), Guatemala City

INTERVASC ( Site 0605), Guatemala City

01015

Grupo Angeles SA ( Site 0604), Guatemala City

09001

Centro Regional de Sub Especialidades Médicas SA ( Site 0600), Quetzaltenango

791-0295

Ehime University Hospital ( Site 3005), Tōon

830-0011

Kurume University Hospital ( Site 3006), Kurume

003-0804

National Hospital Organization Hokkaido Cancer Center ( Site 3014), Sapporo

920-8641

Kanazawa University Hospital ( Site 3004), Kanazawa

236-0051

Kanagawa Cardiovascular and Respiratory Center ( Site 3003), Yokohama

981-1293

Miyagi Cancer Center ( Site 3000), Natori-shi

980-0873

Sendai Kousei Hospital ( Site 3015), Sendai

710-8602

Kurashiki Central Hospital ( Site 3013), Kurashiki

573-1191

Kansai Medical University Hospital ( Site 3016), Hirakata

Unknown

National Hospital Organization Kinki-chuo Chest Medical Center ( Site 3009), Sakai

569-8686

Osaka Medical and Pharmaceutical University Hospital ( Site 3017), Takatsuki

260-8677

Chiba University Hospital ( Site 3008), Chiba

810-8563

National Hospital Organization Kyushu Medical Center ( Site 3001), Fukuoka

811-1395

National Hospital Organization Kyushu Cancer Center ( Site 3002), Fukuoka

541-8567

Osaka International Cancer Institute ( Site 3018), Osaka

770-8503

Tokushima University Hospital ( Site 3019), Tokushima

113-8431

Juntendo University Hospital ( Site 3011), Tokyo

142-8666

Showa University Hospital ( Site 3010), Tokyo

04001

Hospital Nacional Carlos Alberto Seguin Escobedo ESSALUD ( Site 0704), Arequipa

62-500

Przychodnia Lekarska KOMED ( Site 1202), Konin

85-796

Centrum Onkologii im prof Franciszka Lukaszczyka ( Site 1201), Bydgoszcz

08-110

Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 1206), Siedlce

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (, Warsaw

43-360

Centrum Pulmonologii i Torakochirurgii w Bystrej ( Site 1205), Bystra

75-581

Szpital Wojewodzki im. Mikolaja Kopernika ( Site 1200), Koszalin

022548

S.C.Focus Lab Plus S.R.L ( Site 1301), Bucharest

050098

Spitalul Universitar de Urgenta Bucuresti ( Site 1305), Bucharest

0002

Steve Biko Academic Hospital ( Site 1506), Pretoria

0181

Marry Potter Oncology Centre ( Site 1502), Pretoria

08308

Korea University Guro Hospital ( Site 2003), Seoul

08035

H.U. Vall de Hebron ( Site 1600), Barcelona

06010

Gulhane Egitim ve Arastirma Hastanesi ( Site 1704), Ankara

06800

Ankara Sehir Hastanesi ( Site 1702), Ankara

08173

Medical Center Asklepion LLC ( Site 1804), Khodosovka

03115

Kyiv City Clinical Oncology Centre ( Site 1809), Kyiv

03151

Medical Center Dobrobut Clinic ( Site 1808), Kyiv

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY