Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,174

Participants

Timeline

Start Date

November 29, 2022

Primary Completion Date

December 31, 2026

Study Completion Date

May 31, 2027

Conditions
Autosomal Dominant Polycystic Kidney Disease
Interventions
DRUG

Metformin XR

Extended release metformin.

OTHER

Control

Placebo is inactive tablets that is identical to the intervention Metformin tablets.

Trial Locations (40)

2050

ACTIVE_NOT_RECRUITING

Royal Prince Alfred Hospital, Sydney

2065

ACTIVE_NOT_RECRUITING

Royal North Shore Hospital, Sydney

2145

ACTIVE_NOT_RECRUITING

Westmead Hospital - Western Sydney Local Health District, Sydney

2250

ACTIVE_NOT_RECRUITING

Renal Research, Gosford

3052

ACTIVE_NOT_RECRUITING

Royal Melbourne Hospital, Melbourne

3084

ACTIVE_NOT_RECRUITING

Austin Health, Melbourne

3112

RECRUITING

Te Whatu Ora - Hauora a Toi Bay of Plenty, Tauranga

3168

ACTIVE_NOT_RECRUITING

Monash Medical Centre, Melbourne

4006

ACTIVE_NOT_RECRUITING

Royal Brisbane and Women's Hospital, Herston

4102

ACTIVE_NOT_RECRUITING

Princess Alexandra Hospital, Woolloongabba

4310

RECRUITING

Te Whatu Ora - Taranaki, New Plymouth

4670

ACTIVE_NOT_RECRUITING

Bundaberg Hospital, Bundaberg

4814

ACTIVE_NOT_RECRUITING

Townsville University Hospital, Douglas

5000

RECRUITING

Royal Adelaide Hospital, Adelaide

6009

ACTIVE_NOT_RECRUITING

Sir Charles Gairdner Hospital, Perth

9016

RECRUITING

Te Whatu Ora - Southern, Dunedin

0110

RECRUITING

Te Whatu Ora - Te Tai Tokerau, Whangārei

EX2 5DW

NOT_YET_RECRUITING

Royal Devon & Exeter Hospital, Exeter

NG5 1PB

NOT_YET_RECRUITING

Nottingham Renal Unit, Nottingham City Hospital, Nottingham

IV2 3UJ

NOT_YET_RECRUITING

Raigmore Hospital, Inverness

PR2 9HT

NOT_YET_RECRUITING

Royal Preston Hospital, Preston

M6 8HD

NOT_YET_RECRUITING

Salford Royal Hospital, Salford

LE5 4PW

NOT_YET_RECRUITING

Leicester General Hospital, Leicester

SM5 1AA

NOT_YET_RECRUITING

St Helier Hospital, Carshalton

E1 1FR

NOT_YET_RECRUITING

The Royal London Hospital, London

NW3 2QG

NOT_YET_RECRUITING

Royal Free Hospital, London

SE5 9RS

NOT_YET_RECRUITING

King's College Hospital, London

L9 7AL

NOT_YET_RECRUITING

Aintree University Hospital, Liverpool

NR4 7UY

NOT_YET_RECRUITING

Norfolk and Norwich University Hospital, Norwich

BT41 2RL

NOT_YET_RECRUITING

Antrim Area Hospital, Antrim

BT16 1RH

NOT_YET_RECRUITING

Ulster Hospital, Belfast

BT47 6SB

NOT_YET_RECRUITING

Altnagelvin Hospital, Londonderry

BT35 8DR

NOT_YET_RECRUITING

Daisy Hill Hospital, Newry

OX3 7LE

NOT_YET_RECRUITING

Oxford Kidney Unit, Churchill Hospital,, Oxford

DN2 5LT

NOT_YET_RECRUITING

Doncaster Royal Infirmary, Doncaster

S5 7AU

NOT_YET_RECRUITING

Sheffield Kidney Institute, Sheffield

ST4 6QG

NOT_YET_RECRUITING

Royal Stoke University Hospital, Stoke-on-Trent

NE7 7DN

NOT_YET_RECRUITING

Freeman Hospital, Newcastle upon Tyne

B15 2GW

NOT_YET_RECRUITING

Queen Elizabeth Hospital Birmingham, Birmingham

BD5 0NA

NOT_YET_RECRUITING

Bradford Renal Unit, St Luke's Hospital, Bradford

All Listed Sponsors
lead

The University of Queensland

OTHER