192
Participants
Start Date
May 10, 2022
Primary Completion Date
June 30, 2026
Study Completion Date
September 30, 2027
Biospecimen Collection
Undergo blood sample collection
Cognitive Assessment
Complete cognitive testing
Magnetic Resonance Imaging
Undergo MRI
Memantine Hydrochloride
Given PO
Placebo Administration
Given PO
Questionnaire Administration
Ancillary studies
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
Mount Sinai Hospital, New York
Memorial Sloan Kettering Cancer Center, New York
Montefiore Medical Center - Moses Campus, The Bronx
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
Maimonides Medical Center, Brooklyn
Stony Brook University Medical Center, Stony Brook
Albany Medical Center, Albany
State University of New York Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
Geisinger Medical Center, Danville
Lehigh Valley Hospital-Cedar Crest, Allentown
Children's Hospital of Philadelphia, Philadelphia
Saint Christopher's Hospital for Children, Philadelphia
Alfred I duPont Hospital for Children, Wilmington
Children's National Medical Center, Washington D.C.
Sinai Hospital of Baltimore, Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
University of Virginia Cancer Center, Charlottesville
VCU Massey Comprehensive Cancer Center, Richmond
Children's Hospital of The King's Daughters, Norfolk
Carilion Children's, Roanoke
West Virginia University Healthcare, Morgantown
Wake Forest University Health Sciences, Winston-Salem
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Duke University Medical Center, Durham
East Carolina University, Greenville
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Mission Hospital, Asheville
Prisma Health Richland Hospital, Columbia
BI-LO Charities Children's Cancer Center, Greenville
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
Nemours Children's Clinic-Jacksonville, Jacksonville
University of Florida Health Science Center - Gainesville, Gainesville
AdventHealth Orlando, Orlando
Nemours Children's Hospital, Orlando
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
Nicklaus Children's Hospital, Miami
Miami Cancer Institute, Miami
Tampa General Hospital, Tampa
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Johns Hopkins All Children's Hospital, St. Petersburg
Golisano Children's Hospital of Southwest Florida, Fort Myers
Children's Hospital of Alabama, Birmingham
The Children's Hospital at TriStar Centennial, Nashville
Vanderbilt University/Ingram Cancer Center, Nashville
East Tennessee Childrens Hospital, Knoxville
Saint Jude Children's Research Hospital, Memphis
University of Mississippi Medical Center, Jackson
Norton Children's Hospital, Louisville
Nationwide Children's Hospital, Columbus
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
Rainbow Babies and Childrens Hospital, Cleveland
Cleveland Clinic Foundation, Cleveland
Children's Hospital Medical Center of Akron, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Dayton Children's Hospital, Dayton
Riley Hospital for Children, Indianapolis
Corewell Health Children's, Royal Oak
C S Mott Children's Hospital, Ann Arbor
Children's Hospital of Michigan, Detroit
Michigan State University, East Lansing
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
Blank Children's Hospital, Des Moines
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
Children's Hospital of Wisconsin, Milwaukee
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Marshfield Medical Center-Marshfield, Marshfield
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
Mayo Clinic in Rochester, Rochester
Sanford Broadway Medical Center, Fargo
Loyola University Medical Center, Maywood
University of Illinois, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Saint Jude Midwest Affiliate, Peoria
Cardinal Glennon Children's Medical Center, St Louis
Washington University School of Medicine, St Louis
Mercy Hospital Saint Louis, St Louis
Children's Mercy Hospitals and Clinics, Kansas City
University of Missouri Children's Hospital, Columbia
Children's Hospital and Medical Center of Omaha, Omaha
University of Nebraska Medical Center, Omaha
Children's Hospital New Orleans, New Orleans
Ochsner Medical Center Jefferson, New Orleans
University of Oklahoma Health Sciences Center, Oklahoma City
Medical City Dallas Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Cook Children's Medical Center, Fort Worth
M D Anderson Cancer Center, Houston
Children's Hospital of San Antonio, San Antonio
Methodist Children's Hospital of South Texas, San Antonio
University of Texas Health Science Center at San Antonio, San Antonio
Dell Children's Medical Center of Central Texas, Austin
El Paso Children's Hospital, El Paso
Children's Hospital Colorado, Aurora
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
Saint Luke's Cancer Institute - Boise, Boise
Primary Children's Hospital, Salt Lake City
Phoenix Childrens Hospital, Phoenix
Banner Children's at Desert, Mesa
Banner University Medical Center - Tucson, Tucson
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
Summerlin Hospital Medical Center, Las Vegas
Children's Hospital Los Angeles, Los Angeles
Kaiser Permanente Downey Medical Center, Downey
Miller Children's and Women's Hospital Long Beach, Long Beach
Rady Children's Hospital - San Diego, San Diego
Loma Linda University Medical Center, Loma Linda
Children's Hospital of Orange County, Orange
Valley Children's Hospital, Madera
UCSF Medical Center-Mission Bay, San Francisco
Lucile Packard Children's Hospital Stanford University, Palo Alto
UCSF Benioff Children's Hospital Oakland, Oakland
Kaiser Permanente-Oakland, Oakland
Kapiolani Medical Center for Women and Children, Honolulu
Legacy Emanuel Children's Hospital, Portland
Oregon Health and Science University, Portland
Seattle Children's Hospital, Seattle
Mary Bridge Children's Hospital and Health Center, Tacoma
Madigan Army Medical Center, Tacoma
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
Providence Alaska Medical Center, Anchorage
Arkansas Children's Hospital, Little Rock
Connecticut Children's Medical Center, Hartford
Maine Children's Cancer Program, Scarborough
Walter Reed National Military Medical Center, Bethesda
Massachusetts General Hospital Cancer Center, Boston
Dana-Farber Cancer Institute, Boston
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
Hackensack University Medical Center, Hackensack
Morristown Medical Center, Morristown
Saint Peter's University Hospital, New Brunswick
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
Saint Joseph's Regional Medical Center, Paterson
Rhode Island Hospital, Providence
Sanford USD Medical Center - Sioux Falls, Sioux Falls
HIMA San Pablo Oncologic Hospital, Caguas
Children's Oncology Group
NETWORK