Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients

PHASE3RecruitingINTERVENTIONAL
Enrollment

360

Participants

Timeline

Start Date

January 3, 2022

Primary Completion Date

April 1, 2026

Study Completion Date

December 31, 2026

Conditions
Advanced Malignant Solid NeoplasmAnorexiaHematopoietic and Lymphoid Cell Neoplasm
Interventions
DRUG

Olanzapine

Given PO

DRUG

Megestrol Acetate

Given PO

OTHER

Questionnaire Administration

Ancillary studies

Trial Locations (290)

10468

RECRUITING

James J Peters VA Medical Center, The Bronx

11432

RECRUITING

Queens Hospital Center, Jamaica

12801

RECRUITING

Glens Falls Hospital, Glens Falls

17822

RECRUITING

Geisinger Medical Center, Danville

17837

RECRUITING

Geisinger Medical Oncology-Lewisburg, Lewisburg

17901

RECRUITING

Geisinger Cancer Services-Pottsville, Pottsville

18201

RECRUITING

Geisinger Medical Center-Cancer Center Hazleton, Hazleton

18510

RECRUITING

Community Medical Center, Scranton

18711

RECRUITING

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

18840

RECRUITING

Guthrie Medical Group PC-Robert Packer Hospital, Sayre

19713

SUSPENDED

Delaware Clinical and Laboratory Physicians PA, Newark

RECRUITING

Helen F Graham Cancer Center, Newark

RECRUITING

Medical Oncology Hematology Consultants PA, Newark

19801

RECRUITING

Christiana Care Health System-Wilmington Hospital, Wilmington

19967

RECRUITING

Beebe South Coastal Health Campus, Millville

19971

RECRUITING

Beebe Health Campus, Rehoboth Beach

20002

RECRUITING

Kaiser Permanente-Capitol Hill Medical Center, Washington D.C.

20774

RECRUITING

Kaiser Permanente - Largo Medical Center, Largo

20879

RECRUITING

Kaiser Permanente-Gaithersburg Medical Center, Gaithersburg

21014

ACTIVE_NOT_RECRUITING

UM Upper Chesapeake Medical Center, Bel Air

21093

RECRUITING

Kaiser Permanente Lutherville - Timonium Medical Center, Lutherville

21204

RECRUITING

UM Saint Joseph Medical Center, Towson

21244

RECRUITING

Kaiser Permanente-Woodlawn Medical Center, Baltimore

22102

RECRUITING

Kaiser Permanente Tysons Corner Medical Center, McLean

22192

RECRUITING

Kaiser Permanente-Caton Hill Medical Center, Woodbridge

24201

RECRUITING

Ballad Health Cancer Care - Bristol, Bristol

24273

RECRUITING

Ballad Health Cancer Care - Norton, Norton

27534

RECRUITING

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

27834

RECRUITING

East Carolina University, Greenville

27889

RECRUITING

Marion L Shepard Cancer Center - ECU Health Beaufort Hospital, Washington

28025

RECRUITING

Atrium Health Cabarrus/LCI-Concord, Concord

28043

RECRUITING

Levine Cancer Institute - Rutherford, Forest City

28054

RECRUITING

CaroMont Regional Medical Center, Gastonia

RECRUITING

Levine Cancer Institute-Gaston, Gastonia

28112

RECRUITING

Atrium Health Union/LCI-Union, Monroe

28203

RECRUITING

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28210

RECRUITING

Atrium Health Pineville/LCI-Pineville, Charlotte

28262

RECRUITING

Atrium Health University City/LCI-University, Charlotte

28328

RECRUITING

Southeastern Medical Oncology Center-Clinton, Clinton

28374

RECRUITING

FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst

28546

RECRUITING

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

29316

RECRUITING

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29440

RECRUITING

Tidelands Georgetown Memorial Hospital, Georgetown

29605

RECRUITING

Prisma Health Cancer Institute - Butternut, Greenville

RECRUITING

Prisma Health Cancer Institute - Faris, Greenville

RECRUITING

Prisma Health Greenville Memorial Hospital, Greenville

29615

RECRUITING

Prisma Health Cancer Institute - Eastside, Greenville

29640

RECRUITING

Prisma Health Cancer Institute - Easley, Easley

29650

RECRUITING

Prisma Health Cancer Institute - Greer, Greer

29672

RECRUITING

Prisma Health Cancer Institute - Seneca, Seneca

29732

RECRUITING

Levine Cancer Institute-Rock Hill, Rock Hill

30214

RECRUITING

Piedmont Fayette Hospital, Fayetteville

30265

RECRUITING

Piedmont Newnan Hospital, Newnan

30281

RECRUITING

Piedmont Henry Hospital, Stockbridge

30309

RECRUITING

Piedmont Hospital, Atlanta

32114

RECRUITING

Halifax Health Medical Center-Centers for Oncology, Daytona Beach

32127

RECRUITING

Halifax Health Center for Oncology - Port Orange, Port Orange

32174

RECRUITING

Halifax Health Center for Oncology - Ormond Beach, Ormond Beach

33563

SUSPENDED

South Florida Baptist Hospital, Plant City

33705

RECRUITING

Saint Anthony's Hospital Cancer Care Center, St. Petersburg

33756

RECRUITING

Morton Plant Hospital, Clearwater

33905

RECRUITING

Regional Cancer Center-Lee Memorial Health System, Fort Myers

34695

RECRUITING

Mease Countryside Hospital, Safety Harbor

37604

RECRUITING

Regional Cancer Center at Johnson City Medical Center, Johnson City

37620

RECRUITING

Bristol Regional Medical Center, Bristol

37660

RECRUITING

Ballad Health Cancer Care - Kingsport, Kingsport

RECRUITING

Wellmont Holston Valley Hospital and Medical Center, Kingsport

38017

SUSPENDED

Baptist Memorial Hospital and Cancer Center-Collierville, Collierville

38120

RECRUITING

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

38652

SUSPENDED

Baptist Memorial Hospital and Cancer Center-Union County, New Albany

38671

SUSPENDED

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven

38901

SUSPENDED

Baptist Cancer Center-Grenada, Grenada

39705

SUSPENDED

Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus

40509

RECRUITING

Saint Joseph Hospital East, Lexington

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

45801

RECRUITING

Saint Rita's Medical Center, Lima

46202

RECRUITING

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

46307

RECRUITING

Northwest Cancer Center - Main Campus, Crown Point

46311

RECRUITING

Northwest Oncology LLC, Dyer

46312

RECRUITING

Saint Catherine Hospital, Indianapolis

46321

RECRUITING

The Community Hospital, Munster

RECRUITING

Women's Diagnostic Center - Munster, Munster

46342

RECRUITING

Northwest Cancer Center - Hobart, Hobart

RECRUITING

Saint Mary Medical Center, Hobart

46383

RECRUITING

Northwest Cancer Center - Valparaiso, Valparaiso

48044

RECRUITING

Henry Ford Saint John Hospital - Macomb Medical, Macomb

48054

RECRUITING

Henry Ford River District Hospital, East China Township

48093

SUSPENDED

Henry Ford Health Warren Hospital, Warren

RECRUITING

Henry Ford Warren Hospital - GLCMS, Warren

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

RECRUITING

Huron Gastroenterology PC, Ypsilanti

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

RECRUITING

Trinity Health Medical Center - Brighton, Brighton

48118

RECRUITING

Chelsea Hospital, Chelsea

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

RECRUITING

Trinity Health Medical Center - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48236

RECRUITING

Henry Ford Health Saint John Hospital, Detroit

RECRUITING

Henry Ford Saint John Hospital - Van Elslander, Grosse Pointe Woods

48312

SUSPENDED

Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights

48341

RECRUITING

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48503

RECRUITING

Cancer Hematology Centers - Flint, Flint

SUSPENDED

Genesee Hematology Oncology PC, Flint

RECRUITING

Genesys Hurley Cancer Institute, Flint

48601

RECRUITING

MyMichigan Medical Center Saginaw, Saginaw

48764

SUSPENDED

MyMichigan Medical Center Tawas, Tawas City

50010

RECRUITING

Mary Greeley Medical Center, Ames

RECRUITING

McFarland Clinic - Ames, Ames

50036

RECRUITING

McFarland Clinic - Boone, Boone

50129

RECRUITING

McFarland Clinic - Jefferson, Jefferson

50158

RECRUITING

McFarland Clinic - Marshalltown, Marshalltown

50309

RECRUITING

Iowa Methodist Medical Center, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

SUSPENDED

Mercy Medical Center - Des Moines, Des Moines

50501

RECRUITING

McFarland Clinic - Trinity Cancer Center, Fort Dodge

52242

ACTIVE_NOT_RECRUITING

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

52403

RECRUITING

Oncology Associates at Mercy Medical Center, Cedar Rapids

52722

ACTIVE_NOT_RECRUITING

University of Iowa Healthcare Cancer Services Quad Cities, Bettendorf

53051

RECRUITING

Froedtert Menomonee Falls Hospital, Menomonee Falls

53095

RECRUITING

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend

53154

RECRUITING

Drexel Town Square Health Center, Oak Creek

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

54017

RECRUITING

Cancer Center of Western Wisconsin, New Richmond

54166

RECRUITING

ThedaCare Cancer Care - Shawano, Shawano

54301

RECRUITING

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

RECRUITING

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54601

RECRUITING

Gundersen Lutheran Medical Center, La Crosse

54701

ACTIVE_NOT_RECRUITING

Mayo Clinic Health System-Eau Claire Clinic, Eau Claire

54806

RECRUITING

Duluth Clinic Ashland, Ashland

54904

RECRUITING

ThedaCare Cancer Care - Oshkosh, Oshkosh

54911

RECRUITING

ThedaCare Regional Cancer Center, Appleton

54923

RECRUITING

ThedaCare Cancer Care - Berlin, Berlin

54956

RECRUITING

ThedaCare Regional Medical Center - Neenah, Neenah

54961

RECRUITING

ThedaCare Cancer Care - New London, New London

54981

RECRUITING

ThedaCare Cancer Care - Waupaca, Waupaca

55072

RECRUITING

Essentia Health Sandstone, Sandstone

55082

RECRUITING

Lakeview Hospital, Stillwater

55101

RECRUITING

Regions Hospital, Saint Paul

55102

RECRUITING

United Hospital, Saint Paul

55379

RECRUITING

Saint Francis Regional Medical Center, Shakopee

55407

RECRUITING

Abbott-Northwestern Hospital, Minneapolis

55416

RECRUITING

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55417

RECRUITING

Minneapolis VA Medical Center, Minneapolis

55433

RECRUITING

Mercy Hospital, Coon Rapids

55435

RECRUITING

Fairview Southdale Hospital, Edina

55455

ACTIVE_NOT_RECRUITING

University of Minnesota/Masonic Cancer Center, Minneapolis

55746

RECRUITING

Essentia Health Hibbing Clinic, Hibbing

55792

RECRUITING

Essentia Health Virginia Clinic, Virginia

55805

RECRUITING

Essentia Health Cancer Center, Duluth

RECRUITING

Saint Luke's Hospital of Duluth, Duluth

55905

ACTIVE_NOT_RECRUITING

Mayo Clinic in Rochester, Rochester

56007

ACTIVE_NOT_RECRUITING

Mayo Clinic Health System in Albert Lea, Albert Lea

56073

RECRUITING

New Ulm Medical Center, New Ulm

56187

RECRUITING

Sanford Cancer Center Worthington, Worthington

56201

RECRUITING

Rice Memorial Hospital, Willmar

56303

RECRUITING

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

56401

RECRUITING

Essentia Health Saint Joseph's Medical Center, Brainerd

56470

RECRUITING

Essentia Health - Park Rapids, Park Rapids

56501

RECRUITING

Essentia Health Saint Mary's - Detroit Lakes Clinic, Detroit Lakes

56542

RECRUITING

Essentia Health - Fosston, Fosston

56601

RECRUITING

Sanford Joe Lueken Cancer Center, Bemidji

56636

RECRUITING

Essentia Health - Deer River Clinic, Deer River

56701

RECRUITING

Sanford Thief River Falls Medical Center, Thief River Falls

57104

RECRUITING

Sanford Cancer Center Oncology Clinic, Sioux Falls

57701

ACTIVE_NOT_RECRUITING

Rapid City Regional Hospital, Rapid City

58103

RECRUITING

Essentia Health Cancer Center-South University Clinic, Fargo

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

RECRUITING

Sanford Roger Maris Cancer Center, Fargo

58201

ACTIVE_NOT_RECRUITING

Altru Cancer Center, Grand Forks

58401

RECRUITING

Essentia Health - Jamestown Clinic, Jamestown

58501

RECRUITING

Sanford Bismarck Medical Center, Bismarck

59101

RECRUITING

Billings Clinic Cancer Center, Billings

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

60026

RECRUITING

Northwestern Medicine Glenview Outpatient Center, Glenview

60030

RECRUITING

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60045

RECRUITING

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

RECRUITING

Northwestern Medicine Cancer Center Delnor, Geneva

60305

SUSPENDED

West Suburban Medical Center, River Forest

60426

ACTIVE_NOT_RECRUITING

Ingalls Memorial Hospital, Harvey

60462

RECRUITING

Northwestern Medicine Orland Park, Orland Park

60504

RECRUITING

Rush-Copley Medical Center, Aurora

60523

RECRUITING

Northwestern Medicine Oak Brook, Oak Brook

60555

RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60560

RECRUITING

Rush-Copley Healthcare Center, Yorkville

60608

RECRUITING

Mount Sinai Hospital Medical Center, Chicago

60611

RECRUITING

Northwestern University, Chicago

61021

RECRUITING

Illinois CancerCare-Dixon, Dixon

61350

RECRUITING

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

RECRUITING

Illinois CancerCare-Peru, Peru

61356

RECRUITING

Illinois CancerCare-Princeton, Princeton

61401

RECRUITING

Illinois CancerCare-Galesburg, Galesburg

61443

RECRUITING

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

RECRUITING

Illinois CancerCare-Macomb, Macomb

61520

RECRUITING

Illinois CancerCare-Canton, Canton

61530

RECRUITING

Illinois CancerCare-Eureka, Eureka

61554

RECRUITING

Illinois CancerCare-Pekin, Pekin

61571

RECRUITING

Illinois CancerCare - Washington, Washington

61615

RECRUITING

Illinois CancerCare-Peoria, Peoria

61704

RECRUITING

Illinois CancerCare-Bloomington, Bloomington

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

62321

RECRUITING

Illinois CancerCare-Carthage, Carthage

62401

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

62801

RECRUITING

Centralia Oncology Clinic, Centralia

63017

RECRUITING

Saint Luke's Hospital, Chesterfield

63080

SUSPENDED

Missouri Baptist Sullivan Hospital, Sullivan

63127

SUSPENDED

BJC Outpatient Center at Sunset Hills, Sunset Hills

63131

SUSPENDED

Missouri Baptist Medical Center, St Louis

63141

SUSPENDED

Mercy Hospital Saint Louis, St Louis

63640

SUSPENDED

Parkland Health Center - Farmington, Farmington

63670

SUSPENDED

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

RECRUITING

Saint Francis Medical Center, Cape Girardeau

64506

RECRUITING

Heartland Regional Medical Center, Saint Joseph

72401

RECRUITING

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro

75080

RECRUITING

UT Southwestern Clinical Center at Richardson/Plano, Richardson

75237

RECRUITING

UT Southwestern Simmons Cancer Center - RedBird, Dallas

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

RECRUITING

Tarrant County Hospital District/JPS Health Network, Fort Worth

RECRUITING

UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth

77701

ACTIVE_NOT_RECRUITING

Baptist Hospitals of Southeast Texas Cancer Center, Beaumont

79106

RECRUITING

The Don and Sybil Harrington Cancer Center, Amarillo

79601

RECRUITING

Hendrick Medical Center, Abilene

80012

RECRUITING

Rocky Mountain Cancer Centers-Aurora, Aurora

80112

RECRUITING

Rocky Mountain Cancer Centers - Centennial, Centennial

80113

SUSPENDED

Mountain Blue Cancer Care Center - Swedish, Englewood

RECRUITING

Rocky Mountain Cancer Centers - Swedish, Englewood

80124

RECRUITING

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree

80218

RECRUITING

Rocky Mountain Cancer Centers-Midtown, Denver

80220

RECRUITING

Rocky Mountain Cancer Centers-Rose, Denver

80228

RECRUITING

Rocky Mountain Cancer Centers-Lakewood, Lakewood

80260

SUSPENDED

Rocky Mountain Cancer Centers-Thornton, Thornton

80304

RECRUITING

Rocky Mountain Cancer Centers-Boulder, Boulder

81505

RECRUITING

Grand Valley Oncology, Grand Junction

83605

RECRUITING

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83687

RECRUITING

Saint Alphonsus Cancer Care Center-Nampa, Nampa

83706

RECRUITING

Saint Alphonsus Cancer Care Center-Boise, Boise

83814

RECRUITING

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

RECRUITING

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

RECRUITING

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

85027

RECRUITING

Arizona Center for Cancer Care - Phoenix, Phoenix

85251

RECRUITING

Arizona Center for Cancer Care - Osborn, Scottsdale

85258

RECRUITING

Arizona Center for Cancer Care - Scottsdale, Scottsdale

85297

RECRUITING

Arizona Center for Cancer Care - Gilbert, Gilbert

85338

RECRUITING

CTCA at Western Regional Medical Center, Goodyear

85374

RECRUITING

Arizona Center for Cancer Care-Surprise, Surprise

85381

RECRUITING

Arizona Center for Cancer Care-Peoria, Peoria

87102

RECRUITING

Lovelace Medical Center-Saint Joseph Square, Albuquerque

87106

RECRUITING

University of New Mexico Cancer Center, Albuquerque

88011

RECRUITING

Memorial Medical Center-Las Cruces, Las Cruces

89052

SUSPENDED

OptumCare Cancer Care at Seven Hills, Henderson

89102

SUSPENDED

OptumCare Cancer Care at Charleston, Las Vegas

89144

SUSPENDED

Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas

89148

SUSPENDED

OptumCare Cancer Care at Fort Apache, Las Vegas

89169

SUSPENDED

Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas

94110

RECRUITING

Zuckerberg San Francisco General Hospital, San Francisco

94538

RECRUITING

Washington Hospital, Fremont

94568

ACTIVE_NOT_RECRUITING

Epic Care-Dublin, Dublin

94597

ACTIVE_NOT_RECRUITING

Epic Care Cyberknife Center, Walnut Creek

94608

ACTIVE_NOT_RECRUITING

Epic Care Partners in Cancer Care, Emeryville

94609

ACTIVE_NOT_RECRUITING

Bay Area Tumor Institute, Oakland

95065

RECRUITING

Dominican Santa Cruz Hospital, Santa Cruz

96701

RECRUITING

Hawaii Cancer Care - Westridge, ‘Aiea

RECRUITING

Pali Momi Medical Center, ‘Aiea

96706

RECRUITING

The Queen's Medical Center - West Oahu, ‘Ewa Beach

96734

SUSPENDED

Castle Medical Center, Kailua

96813

RECRUITING

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

RECRUITING

Queen's Cancer Cenrer - POB I, Honolulu

RECRUITING

Queen's Medical Center, Honolulu

RECRUITING

Straub Clinic and Hospital, Honolulu

96817

RECRUITING

Queen's Cancer Center - Kuakini, Honolulu

96826

RECRUITING

Kapiolani Medical Center for Women and Children, Honolulu

98055

SUSPENDED

Valley Medical Center, Renton

94553-3156

SUSPENDED

Contra Costa Regional Medical Center, Martinez

02111

ACTIVE_NOT_RECRUITING

Tufts Medical Center, Boston

03833

RECRUITING

Exeter Hospital, Exeter

08822

RECRUITING

Hunterdon Medical Center, Flemington

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

05602

RECRUITING

Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners

05401

RECRUITING

University of Vermont Medical Center, Burlington

05405

RECRUITING

University of Vermont and State Agricultural College, Burlington

54235-1495

RECRUITING

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Alliance for Clinical Trials in Oncology

OTHER