Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

August 19, 2021

Primary Completion Date

May 20, 2026

Study Completion Date

December 10, 2029

Conditions
Small Cell Lung Carcinoma
Interventions
BIOLOGICAL

coformulation pembrolizumab/quavonlimab

Intravenous (IV) infusion

DRUG

lenvatinib

Oral administration

BIOLOGICAL

MK-4830

IV infusion

BIOLOGICAL

coformulation favezelimab/pembrolizumab

IV infusion

BIOLOGICAL

R-DXd

IV Infusion

Trial Locations (48)

1140

RECRUITING

Standort Penzing der Klinik Ottakring-Abteilung für Atemwegs-und Lungenkrankheiten ( Site 3101), Vienna

1210

RECRUITING

Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 3100), Vienna

2145

COMPLETED

Westmead Hospital-Department of Medical Oncology ( Site 4004), Westmead

3168

RECRUITING

Monash Health-Oncology Research ( Site 4005), Clayton

4032

COMPLETED

The Prince Charles Hospital-Oncology Clinical Trials ( Site 4003), Brisbane

5004

COMPLETED

Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház-Onkologiai Kozpont ( Site 3800), Szolnok

6009

RECRUITING

Hollywood Private Hospital-Medical Oncology ( Site 4001), Perth

9000

ACTIVE_NOT_RECRUITING

Cantonal Hospital St.Gallen-Oncology & Hematology ( Site 3502), Sankt Gallen

13620

RECRUITING

Seoul National University Bundang Hospital-Medical Oncology ( Site 4104), Seongnam

15232

COMPLETED

UPMC Hillman Cancer Center ( Site 0177), Pittsburgh

20089

RECRUITING

Humanitas-U.O di Oncologia medica ed Ematologia ( Site 3301), Rozzano

20132

COMPLETED

Ospedale San Raffaele-Oncologia Medica ( Site 3303), Milan

20141

RECRUITING

Istituto Europeo di Oncologia IRCCS-Divisione di Oncologia Toracica ( Site 3304), Milan

21237

COMPLETED

MFSMC-HJWCI-Oncology Research ( Site 0178), Baltimore

23229

RECRUITING

Virginia Cancer Institute ( Site 0169), Richmond

28644

RECRUITING

Chungbuk National University Hospital ( Site 4106), Cheongju-si

29607

COMPLETED

St Francis Cancer Center-Research Office ( Site 0167), Greenville

30342

COMPLETED

Northside Hospital-Northside Hospital Oncology Network ( Site 0156), Atlanta

40503

COMPLETED

Baptist Health Lexington-Research ( Site 0158), Lexington

40536

COMPLETED

University of Kentucky Chandler Medical Center-Medical Oncology ( Site 0157), Lexington

44195

COMPLETED

Cleveland Clinic-Taussig Cancer Center ( Site 0166), Cleveland

46845

COMPLETED

Parkview Research Center at Parkview Regional Medical Center ( Site 0180), Fort Wayne

53100

RECRUITING

ospedale le scotte-U.O.C. Immunoterapia Oncologica ( Site 3300), Siena

68130

COMPLETED

Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0172), Omaha

COMPLETED

Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0179), Omaha

85234

COMPLETED

Banner MD Anderson Cancer Center ( Site 0152), Gilbert

194291

COMPLETED

GBUZ LOKB-Oncology department #1 ( Site 3701), Saint Petersburg

197758

COMPLETED

"GBUZ SPb CRPCstmc(o) ( Site 3705)", Saint Petersburg

COMPLETED

N.N.Petrov Research Institute of Oncology-Department of Chemotherapy and Innovative Technologies ( Site 3703), Saint Petersburg

COMPLETED

Scientific research institution of oncology named after N.N. Petrov-Thoracic oncology ( Site 3704), Saint Petersburg

198255

COMPLETED

Saint-Petersburg City Clinical Oncology Dispensary-Department of chemotherapy ( Site 3702), Saint Petersburg

660133

COMPLETED

Krasnoyarsk Regional Oncology Dispensary, Named after Krizhanovsky ( Site 3708), Krasnoyarsk

3109601

RECRUITING

Rambam Health Care Campus-Oncology ( Site 3600), Haifa

4428164

RECRUITING

Meir Medical Center. ( Site 3601), Kfar Saba

4941492

RECRUITING

Rabin Medical Center-Oncology ( Site 3604), Petah Tikva

5265601

RECRUITING

Sheba Medical Center-ONCOLOGY ( Site 3603), Ramat Gan

9103102

RECRUITING

Shaare Zedek Medical Center-Oncology ( Site 3602), Jerusalem

T6G 1Z2

COMPLETED

Cross Cancer Institute ( Site 3004), Edmonton

M5G 2M9

COMPLETED

Princess Margaret Cancer Centre ( Site 3003), Toronto

H3T 1M5

COMPLETED

St. Marys Hospital Center ( Site 3000), Montreal

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 3900), Warsaw

10-357

COMPLETED

Warminsko-Mazurskie Centrum Chorob Płuc w Olsztynie ( Site 3903), Olsztyn

03080

RECRUITING

Seoul National University Hospital ( Site 4101), Seoul

05505

COMPLETED

Asan Medical Center-Lung Cancer Center ( Site 4103), Seoul

06351

RECRUITING

Samsung Medical Center ( Site 4100), Seoul

08908

RECRUITING

Instituto Catalan de Oncologia - Hospital Duran i Reynals ( Site 3403), L'Hospitalet de Llobregat

08035

RECRUITING

Hospital Universitari Vall d'Hebron-Oncology ( Site 3401), Barcelona

08036

RECRUITING

Hospital Clinic de Barcelona ( Site 3404), Barcelona

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY