ImproviNg rEnal Outcomes Following Coronary angiograPhy and/or percuTaneoUs coroNary intErventions

NARecruitingINTERVENTIONAL
Enrollment

1,158

Participants

Timeline

Start Date

June 28, 2021

Primary Completion Date

January 30, 2027

Study Completion Date

July 31, 2027

Conditions
Contrast-Induced Acute Kidney Injury
Interventions
PROCEDURE

Personalized hydration strategy

In the experimental group, NS infusion rate will be adjusted based on LVEDP for the whole duration of the procedure (\<13 mmHg: 5 ml/kg/h; 13-18 mmHg: 3 ml/kg/h; \>18 mmHg: 1.5 ml/kg/h), or for one hour, whichever is the longest. After the procedure, and for a duration of 4 hours, the hydration rate will be adjusted based on the (contrast volume:estimated glomerular filtration rate (eGFR)) ratio, according to the following scheme: 1.5 ml/kg/h if contrast volume/eGFR ratio \<2.0; 3 ml/kg/h for contrast volume/eGFR ratio 2.0-2.9; 5 ml/kg/h for contrast volume/eGFR ratio ≥3.0.

PROCEDURE

Standard of care

In the control group, infusion rate will be of 1.5 ml/kg/h during the procedure, and for the 4 following hours.

Trial Locations (1)

H1T1C8

RECRUITING

Montreal Heart Institute, Montreal

All Listed Sponsors
collaborator

Université de Montréal

OTHER

collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

lead

Montreal Heart Institute

OTHER