Flow Rates of High-flow Nasal Cannula and Extubation Outcome

NACompletedINTERVENTIONAL
Enrollment

180

Participants

Timeline

Start Date

September 1, 2021

Primary Completion Date

March 28, 2023

Study Completion Date

April 30, 2023

Conditions
Hypoxemic Respiratory Failure
Interventions
OTHER

Flow rate setting of high-flow nasal cannula (initially 60L/min)

"The flow rates of HFNC(high-flow nasal cannula) is set as 60L/min(temperature:34°C).~Initial FiO2 is 100%, which would be titrated down to the minimal level to keep SpO2 ≥ 92% within 30 minutes after extubation.~After that, the flow rate setting is fixed for 24hrs +/- 6 hrs; then, is tapered to 30 L/min and kept for 12 more hours. Afterwards, HFNC would be changed to conventional oxygen therapy to keep SpO2≥ 92%."

OTHER

Flow rate setting of high-flow nasal cannula (initially 40L/min)

"The flow rates of HFNC(high-flow nasal cannula) is set as 40L/min(temperature:34°C).~Initial FiO2 is 100%, which would be titrated down to the minimal level to keep SpO2 ≥ 92% within 30 minutes after extubation.~After that, the flow rate setting is fixed for 24hrs +/- 6 hrs; then, is tapered to 30 L/min and kept for 12 more hours. Afterwards, HFNC would be changed to conventional oxygen therapy to keep SpO2≥ 92%."

Trial Locations (1)

10002

National Taiwan University Hospital, Taipei

All Listed Sponsors
lead

National Taiwan University Hospital

OTHER

NCT04934163 - Flow Rates of High-flow Nasal Cannula and Extubation Outcome | Biotech Hunter | Biotech Hunter