Early Caries Lesion Management Observational Study

Active, not recruitingOBSERVATIONAL
Enrollment

744

Participants

Timeline

Start Date

December 7, 2020

Primary Completion Date

November 15, 2023

Study Completion Date

March 31, 2024

Conditions
Initial CariesArrested Dental CariesCavitated CariesDental CariesDental Caries in Children
Interventions
DRUG

Curodont Repair Fluoride Plus

Self-assembling peptide that integrates calcium and phosphate ions into the same hydroxyapatite that the enamel is made of through biomimetic re-mineralization. Amino acid sequence: CH3,COQQRFEWEFEQQ,NH2.

DEVICE

Silver Diamine Fluoride

Silver diamine fluoride 38% is indicated for the treatment of dentinal hypersensitivity. SDF works by killing pathogenic organisms and hardens softened dentin making it more acid and abrasion resistant. The ADA recommends the use of SDF in treating early lesions.

DEVICE

Glass Ionomer Sealant

A hydrophilic type of sealant material made with water, polymeric acid, and glass power. These sealants release fluoride over time which also helps protect against and repair initial caries lesions. The ADA recommends the use of sealants in treating occlusal early lesions.

DEVICE

Fluoride varnish

2.5% Sodium Fluoride Varnish which reduces dentinal hypersensitivity by occluding dentinal tubules.

DRUG

Fluoride toothpaste

Prescription sodium fluoride toothpaste medicament used in place of regular toothpaste. It works by making the teeth stronger and more resistant to caries.

Trial Locations (4)

36303

Sarrell Dental Clinic, Dothan

75246

Community Dental Care, Dallas

97701

Advantage Dental Oral Health Center, Bend

01581

DentaQuest (Advantage Dental) Oral Health Center, Westborough

All Listed Sponsors
lead

CareQuest Institute for Oral Health

OTHER