A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

PHASE1RecruitingINTERVENTIONAL
Enrollment

542

Participants

Timeline

Start Date

October 22, 2021

Primary Completion Date

August 9, 2027

Study Completion Date

November 7, 2028

Conditions
Metastatic Colorectal Cancer
Interventions
DRUG

Inavolisib

Inavolisib will be administered orally as per schedule specified in the respective arms.

DRUG

Bevacizumab

Bevacizumab IV will be administered as per schedule specified in the respective arm.

DRUG

Cetuximab

Cetuximab IV will be administered as per schedule specified in the respective arm.

DRUG

Atezolizumab

Atezolizumab IV infusion will be administered as per schedule specified in the respective arm.

DRUG

Tiragolumab

Tiragolumab IV infusion will be administered as per schedule specified in the respective arm.

DRUG

SY-5609

SY-5609 will be administered by mouth as per schedule specified in the respective arm.

DRUG

Divarasib

Divarasib will be administered orally as per schedule specified in the respective arms.

DRUG

FOLFOX

FOLFOX (5-fluorouracil, leucovorin, oxaliplatin) IV will be administered as per schedule specified in the respective arm.

DRUG

FOLFIRI

FOLFIRI (leucovorin, 5-fluorouracil, irinotecan) IV will be administered as per schedule specified in the respective arm.

Trial Locations (73)

2100

RECRUITING

Rigshospitalet, Onkologisk Klinik, København Ø

3000

RECRUITING

Peter Maccallum Cancer Centre, Melbourne

10028

RECRUITING

New York Cancer and Blood Specialists-Central Park Hematology & Oncology, New York

10048

RECRUITING

National Taiwan University Hospital, Zhongzheng Dist.

10408

RECRUITING

National Cancer Center, Goyang-si

11776

RECRUITING

New York Cancer & Blood Specialists, Port Jefferson Station

13353

RECRUITING

Charité Universitätsmedizin Berlin, Berlin

13605

RECRUITING

Seoul National University Bundang Hospital, Seongnam-si

15232

ACTIVE_NOT_RECRUITING

UPMC - Hillman Cancer Center, Pittsburgh

20133

RECRUITING

Irccs Istituto Nazionale Dei Tumori (Int), Milan

20162

RECRUITING

Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda), Milan

22763

RECRUITING

Asklepios Klinik Altona, Hamburg

27710

COMPLETED

Duke University Medical Center, Durham

28040

RECRUITING

START Madrid-FJD, Hospital Fundacion Jimenez Diaz, Madrid

28050

WITHDRAWN

START Madrid. Centro Integral Oncologico Clara Campal, Madrid

32224

ACTIVE_NOT_RECRUITING

Mayo Clinic in Florida, Jacksonville

33612

ACTIVE_NOT_RECRUITING

Moffitt Cancer Center, Tampa

35128

RECRUITING

IRCCS Istituto Oncologico Veneto (IOV), Padua

35233

WITHDRAWN

UAB Comprehensive Cancer Center, Birmingham

37203

COMPLETED

Sarah Cannon Research Institute / Tennessee Oncology, Nashville

37232

ACTIVE_NOT_RECRUITING

Vanderbilt University Medical Center, Nashville

40225

RECRUITING

Universitätsklinikum Düsseldorf, Düsseldorf

44791

RECRUITING

Katholisches Klinikum Bochum gGmbH - St. Josef-Hospital, Bochum

46010

RECRUITING

Hospital Clínico Universitario de Valencia, Valencia

48201

WITHDRAWN

Karmanos Cancer Institute, Detroit

55902

RECRUITING

Mayo Clinic Rochester, Rochester

58128

RECRUITING

Chonnam National University Hwasun Hospital, Jeollanam-do

70809

RECRUITING

Mary Bird Perkins Cancer Ctr, Baton Rouge

74078

RECRUITING

SLK-Kliniken Heilbronn GmbH;Klinik für Innere Medizin III, Heilbronn

77339

WITHDRAWN

Lumi Research, Kingwood

80045

ACTIVE_NOT_RECRUITING

University of Colorado Cancer Center, Aurora

80131

RECRUITING

Università degli Studi della Campania Luigi Vanvitelli, Napoli

81377

RECRUITING

Klinikum der Universität München, Campus Großhadern, München

85259

COMPLETED

Mayo Clinic Arizona, Phoenix

89081

RECRUITING

Universitätsklinikum Ulm, Ulm

90033

RECRUITING

USC Norris Cancer Center, Los Angeles

90048

ACTIVE_NOT_RECRUITING

Cedars-Sinai Medical Center, Los Angeles

90095

RECRUITING

UCLA, Los Angeles

91010

ACTIVE_NOT_RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

92024

WITHDRAWN

cCare, Encinitas

92663

WITHDRAWN

Hoag Memorial Hospital Presbyterian, Newport Beach

97301

ACTIVE_NOT_RECRUITING

Hematology Oncology Salem, Salem

98104

COMPLETED

Swedish Cancer Inst., Seattle

99208

WITHDRAWN

Medical Oncology Associates, Spokane

112201

RECRUITING

Taipei Veterans General Hospital, Taipei

94305-5820

COMPLETED

Stanford Cancer Center, Stanford

06520

RECRUITING

Yale Cancer Center, New Haven

06360

RECRUITING

Eastern Ct Hema/Onco Assoc, Norwich

02114-2621

ACTIVE_NOT_RECRUITING

Massachusetts General Hospital, Boston

11042-1116

RECRUITING

New York Cancer & Blood Specialists - New Hyde Park, New Hyde Park

10469-5930

RECRUITING

New York Cancer & Blood Specialists - Bronx, The Bronx

M5G 1X6

ACTIVE_NOT_RECRUITING

Princess Margaret Cancer Center, Toronto

H3T 1E2

WITHDRAWN

Jewish General Hospital, Montreal

H4A 3J1

WITHDRAWN

McGill University Health Center, Montreal

01307

RECRUITING

Universitätsklinik Carl Gustav Carus der Technischen Universität Dresden, Dresden

00168

RECRUITING

Policlinico Universitario Agostino Gemelli IRCCS, Rome

30-688

SUSPENDED

Szpital Uniwersytecki w Krakowie, Oddzia? Kliniczny Kliniki Onkologii, Krakow

60-569

RECRUITING

Uniwersytecki Szpital Kliniczny w Poznaniu, Poznan

02-781

SUSPENDED

Narodowy Instytut Onkologii im. M. Sklodowskiej-Curie, Warsaw

(0)6351

RECRUITING

Samsung Medical Center, Seoul

03080

RECRUITING

Seoul National University Hospital, Seoul

03722

RECRUITING

Severance Hospital, Yonsei University Health System, Seoul

05505

RECRUITING

Asan Medical Center, Seoul

08035

RECRUITING

Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona

00704

RECRUITING

National Cheng Kung University Hospital, Tainan City

CB2 0QQ

RECRUITING

Addenbrookes Hospital, Cambridge

CF14 2TL

RECRUITING

Velindre Cancer Centre, Cardiff

NW3 2QG

SUSPENDED

Royal Free Hospital, London

SW3 6JJ

RECRUITING

Royal Marsden Hospital;Dept of Med-Onc, London

W1G 6AD

ACTIVE_NOT_RECRUITING

Sarah Cannon Research Institute, London

W2 1NY

ACTIVE_NOT_RECRUITING

Imperial College Healthcare NHS Trust, London

M20 4BX

RECRUITING

The Christie NHS Foundation Trust, Manchester

SM2 5PT

RECRUITING

Royal Marsden Hospital, Sutton

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY