Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

427

Participants

Timeline

Start Date

October 7, 2022

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2027

Conditions
Lung AdenocarcinomaLung Adenosquamous CarcinomaLung Non-Small Cell CarcinomaStage IIIB Lung Cancer AJCC v8Stage IIIC Lung Cancer AJCC v8Stage IV Lung Cancer AJCC v8
Interventions
PROCEDURE

Biopsy Procedure

Undergo tissue biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo CT

PROCEDURE

Echocardiography Test

Undergo ECHO

BIOLOGICAL

Ipilimumab

Given IV

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

BIOLOGICAL

Nivolumab

Given IV

PROCEDURE

Positron Emission Tomography

Undergo PET

OTHER

Quality-of-Life Assessment

Ancillary studies

RADIATION

Radiation Therapy

Undergo radiation therapy

Trial Locations (167)

10011

ACTIVE_NOT_RECRUITING

Mount Sinai Chelsea, New York

10019

ACTIVE_NOT_RECRUITING

Mount Sinai West, New York

10029

ACTIVE_NOT_RECRUITING

Mount Sinai Hospital, New York

10065

RECRUITING

Manhattan Eye Ear and Throat Hospital, New York

10075

RECRUITING

Lenox Hill Hospital, New York

11042

RECRUITING

Northwell Health/Center for Advanced Medicine, Lake Success

13126

RECRUITING

Upstate Cancer Center at Oswego, Oswego

RECRUITING

Upstate Cancer Center Radiation Oncology at Oswego, Oswego

13210

RECRUITING

State University of New York Upstate Medical University, Syracuse

RECRUITING

Upstate Cancer Center at Hill Radiation Oncology, Syracuse

13215

RECRUITING

SUNY Upstate Medical Center-Community Campus, Syracuse

13478

RECRUITING

Upstate Cancer Center at Verona, Verona

14263

ACTIVE_NOT_RECRUITING

Roswell Park Cancer Institute, Buffalo

17822

RECRUITING

Geisinger Medical Center, Danville

17837

RECRUITING

Geisinger Medical Oncology-Lewisburg, Lewisburg

18711

RECRUITING

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19317

RECRUITING

Christiana Care Health System-Concord Health Center, Chadds Ford

19605

RECRUITING

Penn State Health Saint Joseph Medical Center, Reading

19713

RECRUITING

Helen F Graham Cancer Center, Newark

RECRUITING

Medical Oncology Hematology Consultants PA, Newark

19967

RECRUITING

Beebe South Coastal Health Campus, Millville

19971

RECRUITING

Beebe Health Campus, Rehoboth Beach

20010

ACTIVE_NOT_RECRUITING

MedStar Washington Hospital Center, Washington D.C.

23235

RECRUITING

VCU Massey Cancer Center at Stony Point, Richmond

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

25304

RECRUITING

West Virginia University Charleston Division, Charleston

27157

RECRUITING

Wake Forest University Health Sciences, Winston-Salem

27609

RECRUITING

Duke Cancer Center Raleigh, Raleigh

27710

ACTIVE_NOT_RECRUITING

Duke University Medical Center, Durham

29425

RECRUITING

Medical University of South Carolina, Charleston

30265

RECRUITING

CTCA at Southeastern Regional Medical Center, Newnan

31405

RECRUITING

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

RECRUITING

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

33607

RECRUITING

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa

33756

RECRUITING

Morton Plant Hospital, Clearwater

33881

RECRUITING

Winter Haven Hospital, Winter Haven

40509

RECRUITING

Saint Joseph Hospital East, Lexington

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

44304

RECRUITING

Summa Health System - Akron Campus, Akron

46307

RECRUITING

UChicago Medicine Northwest Indiana, Crown Point

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

RECRUITING

Trinity Health Medical Center - Brighton, Brighton

48118

RECRUITING

Chelsea Hospital, Chelsea

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

RECRUITING

Trinity Health Medical Center - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48341

RECRUITING

Michigan Healthcare Professionals Pontiac, Pontiac

RECRUITING

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48503

RECRUITING

Genesys Hurley Cancer Institute, Flint

RECRUITING

Hurley Medical Center, Flint

48601

RECRUITING

MyMichigan Medical Center Saginaw, Saginaw

48604

SUSPENDED

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48661

SUSPENDED

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch

48764

RECRUITING

MyMichigan Medical Center Tawas, Tawas City

48912

RECRUITING

University of Michigan Health - Sparrow Lansing, Lansing

49007

RECRUITING

Bronson Methodist Hospital, Kalamazoo

RECRUITING

West Michigan Cancer Center, Kalamazoo

50010

RECRUITING

Mary Greeley Medical Center, Ames

RECRUITING

McFarland Clinic - Ames, Ames

50023

RECRUITING

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50263

RECRUITING

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50266

RECRUITING

Mercy Medical Center-West Lakes, West Des Moines

50309

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

RECRUITING

Mercy Medical Center - Des Moines, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50325

RECRUITING

Mercy Cancer Center-West Lakes, Clive

RECRUITING

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

50801

RECRUITING

Greater Regional Medical Center, Creston

53066

RECRUITING

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

53149

RECRUITING

ProHealth D N Greenwald Center, Mukwonago

53188

RECRUITING

UW Cancer Center at ProHealth Care, Waukesha

54017

RECRUITING

Cancer Center of Western Wisconsin, New Richmond

54449

RECRUITING

Marshfield Medical Center-Marshfield, Marshfield

54476

RECRUITING

Marshfield Medical Center - Weston, Weston

54482

RECRUITING

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

RECRUITING

Marshfield Medical Center - Minocqua, Minocqua

54601

ACTIVE_NOT_RECRUITING

Gundersen Lutheran Medical Center, La Crosse

ACTIVE_NOT_RECRUITING

Mayo Clinic Health System-Franciscan Healthcare, La Crosse

54701

RECRUITING

Marshfield Medical Center-EC Cancer Center, Eau Claire

54806

RECRUITING

Northwest Wisconsin Cancer Center, Ashland

54868

RECRUITING

Marshfield Medical Center-Rice Lake, Rice Lake

55101

RECRUITING

Regions Hospital, Saint Paul

55415

RECRUITING

Hennepin County Medical Center, Minneapolis

55422

RECRUITING

North Memorial Medical Health Center, Robbinsdale

55805

RECRUITING

Miller-Dwan Hospital, Duluth

55905

WITHDRAWN

Mayo Clinic in Rochester, Rochester

59715

RECRUITING

Bozeman Health Deaconess Hospital, Bozeman

60026

RECRUITING

Northwestern Medicine Glenview Outpatient Center, Glenview

60030

RECRUITING

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60045

RECRUITING

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

RECRUITING

Northwestern Medicine Cancer Center Delnor, Geneva

60426

RECRUITING

Ingalls Memorial Hospital, Harvey

60451

RECRUITING

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

RECRUITING

University of Chicago Medicine-Orland Park, Orland Park

60555

RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

RECRUITING

Northwestern University, Chicago

60612

RECRUITING

University of Illinois, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

61114

RECRUITING

UW Health Carbone Cancer Center Rockford, Rockford

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

RECRUITING

HSHS Saint Elizabeth's Hospital, O'Fallon

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

63080

RECRUITING

Missouri Baptist Sullivan Hospital, Sullivan

63127

RECRUITING

BJC Outpatient Center at Sunset Hills, Sunset Hills

63128

RECRUITING

Mercy Hospital South, St Louis

63131

RECRUITING

Missouri Baptist Medical Center, St Louis

63141

RECRUITING

Mercy Hospital Saint Louis, St Louis

63640

RECRUITING

Parkland Health Center - Farmington, Farmington

63670

RECRUITING

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

RECRUITING

Saint Francis Medical Center, Cape Girardeau

65401

RECRUITING

Phelps Health Delbert Day Cancer Institute, Rolla

65804

RECRUITING

Mercy Hospital Springfield, Springfield

72205

RECRUITING

University of Arkansas for Medical Sciences, Little Rock

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

73120

RECRUITING

Mercy Hospital Oklahoma City, Oklahoma City

73505

RECRUITING

Cancer Centers of Southwest Oklahoma Research, Lawton

79106

RECRUITING

The Don and Sybil Harrington Cancer Center, Amarillo

80524

ACTIVE_NOT_RECRUITING

Poudre Valley Hospital, Fort Collins

80528

ACTIVE_NOT_RECRUITING

Cancer Care and Hematology-Fort Collins, Fort Collins

80538

ACTIVE_NOT_RECRUITING

Medical Center of the Rockies, Loveland

80631

ACTIVE_NOT_RECRUITING

UCHealth Greeley Hospital, Greeley

80909

ACTIVE_NOT_RECRUITING

UCHealth Memorial Hospital Central, Colorado Springs

80920

ACTIVE_NOT_RECRUITING

Memorial Hospital North, Colorado Springs

83301

RECRUITING

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

RECRUITING

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

RECRUITING

Saint Luke's Cancer Institute - Meridian, Meridian

83687

RECRUITING

Saint Luke's Cancer Institute - Nampa, Nampa

83712

RECRUITING

Saint Luke's Cancer Institute - Boise, Boise

85054

ACTIVE_NOT_RECRUITING

Mayo Clinic Hospital in Arizona, Phoenix

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

91030

RECRUITING

City of Hope South Pasadena, South Pasadena

91786

RECRUITING

City of Hope Upland, Upland

92618

RECRUITING

City of Hope at Irvine Lennar, Irvine

93534

RECRUITING

City of Hope Antelope Valley, Lancaster

94558

RECRUITING

Providence Queen of The Valley, Napa

94704

RECRUITING

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

95355

SUSPENDED

Memorial Medical Center, Modesto

95817

RECRUITING

University of California Davis Comprehensive Cancer Center, Sacramento

95901

RECRUITING

Fremont - Rideout Cancer Center, Marysville

96161

RECRUITING

Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee

97030

RECRUITING

Legacy Mount Hood Medical Center, Gresham

97062

RECRUITING

Legacy Meridian Park Hospital, Tualatin

97210

RECRUITING

Legacy Good Samaritan Hospital and Medical Center, Portland

97239

RECRUITING

Oregon Health and Science University, Portland

98684

RECRUITING

Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver

98686

RECRUITING

Legacy Salmon Creek Hospital, Vancouver

99362

RECRUITING

Providence Saint Mary Regional Cancer Center, Walla Walla

04073

RECRUITING

MaineHealth Cancer Care Center of York County, Sanford

04074

RECRUITING

MaineHealth Maine Medical Center- Scarborough, Scarborough

04106

RECRUITING

MaineHealth Cancer Care and IV Therapy - South Portland, South Portland

17033-0850

RECRUITING

Penn State Milton S Hershey Medical Center, Hershey

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH