NCT04928183View on ClinicalTrials.gov

The Impact of Carbon Monoxide and Altitude on Vascular Function

NACompletedINTERVENTIONAL
Enrollment

19

Participants

Timeline

Start Date

June 10, 2021

Primary Completion Date

August 1, 2021

Study Completion Date

May 18, 2022

Conditions
VasodilationVasoconstriction
Interventions
OTHER

Carbon monoxide rebreathe

Carbon monoxide exposure to increase blood (Carboxyhemoglobin) COHb safely to \~10%

DRUG

Sodium Nitroprusside

Bolus Sodium Nitroprusside (SNP) injection for endothelium-independent vasodilation measure

DRUG

Phenylephrine Hydrochloride

Bolus Phenylephrine injection for observe α1-mediated vasoconstriction during mild exercise

Trial Locations (1)

T6G 2R3

University of Alberta, Edmonton

All Listed Sponsors
lead

University of Alberta

OTHER