1,060
Participants
Start Date
July 15, 2021
Primary Completion Date
October 25, 2023
Study Completion Date
December 31, 2023
TXA127
TXA127 0.5 mg/kg/day infused 3 hours daily for 5 days or until hospital discharge whichever comes first.
TRV027
TRV027 12mg/h as a continuous 24-hour infusion, infused for 5 days or until hospital discharge whichever comes first.
Placebo
"NaCl 0.9% infused to match the duration of the agent (3 hours for TXA127 and continuous 24-hour infusion for TRV027, over 30 minutes for APN01.~Orange film-coated, plain bioconvex tablets orally twice daily for 14 days or 28 doses for fostamatinib. Study medication will be continued as an outpatient if the patient is discharged prior to completing 28 doses."
Fostamatinib
Fostamatinib100-150mg orally twice daily for 14 days or 28 doses. Study medication will be continued as an outpatient if the patient is discharged prior to completing 28 doses.
Mount Sinai Hospital, New York
Columbia University Irving Medical Center, New York
Montefiore Medical Center Weiler Campus, The Bronx
Montefiore Medical Center Moses Campus, The Bronx
University of Pittsburgh, Pittsburgh
Temple University Hospital, Philadelphia
Jadestone Clinical Research, LLC, Silver Spring
Johns Hopkins Bayview Medical Center, Baltimore
Johns Hopkins University, Baltimore
UVA Health, Charlottesville
VCU Health, Richmond
Sentara Norfolk General Hospital, Norfolk
Wake Forest University Health Sciences, Winston-Salem
University of North Carolina Medical Center, Chapel Hill
Medical University of South Carolina, Charleston
Ponce de Leon Clinical Research Site, Atlanta
Emory Johns Creek, Atlanta
Emory St. Joseph's Hospital, Atlanta
University of Florida, Gainesville
Public Health Trust of Miami-Dade County, Florida - Jackson Memorial Hospital, Miami
University of Alabama Birmingham, Birmingham
Vanderbilt University Medical Center, Nashville
Cleveland Clinic Fairview Hospital, Cleveland
Cleveland Clinic Foundation, Cleveland
Cleveland Clinic Akron General, Akron
West Chester Hospital, West Chester
University of Cincinnati, Cincinnati
Hennepin County Medical Center, Minneapolis
Alexian Brothers Medical Center, Elk Grove Village
AMITA Health St. Alexius Medical Center, Hoffman Estates
Washington University, St Louis
University of Nebraska Medical Center, Omaha
Ochsner Clinic Foundation, New Orleans
Our Lady of the Lake Regional Medical Center, Baton Rouge
University of Texas, Houston, Houston
University of Colorado Hospital, Aurora
Denver Health Medical Center, Denver
Intermountain Medical Center, Murray
University of Utah Health, Salt Lake City
Chandler Regional Medical Center, Chandler
University of New Mexico Health Sciences Center, Albuquerque
Cedars-Sinai Medical Center, Los Angeles
Stanford University, Stanford
Oregon Health & Science University, Portland
Harborview Medical Center/University of Washington, Seattle
Yale University, New Haven
Beth Israel Deaconess Medical Center, Boston
Massachusetts General Hospital, Boston
Brigham and Women's Hospital, Boston
Newton-Wellesley Hospital, Newton
Baystate Health, Springfield
National Institutes of Health (NIH)
NIH
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Sean Collins
OTHER