Efficacy and Safety of Pembrolizumab Plus Investigational Agents in Combination With Chemotherapy as First-Line Treatment in Extensive-Stage Small Cell Lung Cancer (ES-SCLC) (MK-3475-B99/ KEYNOTE-B99)

PHASE2CompletedINTERVENTIONAL
Enrollment

126

Participants

Timeline

Start Date

July 15, 2021

Primary Completion Date

June 23, 2025

Study Completion Date

June 23, 2025

Conditions
Small Cell Lung Cancer
Interventions
BIOLOGICAL

Pembrolizumab

IV infusion

BIOLOGICAL

MK-4830

IV infusion

BIOLOGICAL

Boserolimab

IV infusion

DRUG

Lenvatinib

Oral capsule

DRUG

Etoposide

IV infusion

DRUG

Cisplatin

IV infusion

DRUG

Carboplatin

IV infusion

Trial Locations (49)

1083

Semmelweis University-Pulmonológiai Klinika ( Site 2802), Budapest

1121

Országos Korányi Pulmonológiai Intézet-XIV. Tüdöbelgyógyászat ( Site 2806), Budapest

1140

Klinik Penzing-2. Lungenabteilung ( Site 2101), Vienna

1210

Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 2100), Vienna

2045

Torokbalint Tudogyogyintezet-Onkopulmonologiai Jarobeteg Centrum ( Site 2801), Törökbálint

5004

Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház-Onkologiai Kozpont ( Site 2800), Szolnok

8900

Zala Megyei Szent Rafael Kórház-Pulmonológia ( Site 2805), Zalaegerszeg

9007

Cantonal Hospital St.Gallen-Oncology & Hematology ( Site 2502), Sankt Gallen

10065

Memorial Sloan Kettering Cancer Center ( Site 0115), New York

11501

Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 0114), Mineola

13620

Seoul National University Bundang Hospital ( Site 1104), Seongnam

15232

UPMC Hillman Cancer Center ( Site 0127), Pittsburgh

16247

The Catholic University Of Korea St. Vincent's Hospital ( Site 1106), Suwon

20132

Ospedale San Raffaele-Oncologia Medica ( Site 2303), Milan

20141

Istituto Europeo di Oncologia IRCCS-Divisione di Oncologia Toracica ( Site 2304), Milan

21237

MFSMC-HJWCI-Oncology Research ( Site 0128), Baltimore

23229

Virginia Cancer Institute ( Site 0119), Richmond

28644

Chungbuk National University Hospital ( Site 1107), Cheongju-si

29607

St Francis Cancer Center-Research Office ( Site 0117), Greenville

30341

Georgia Cancer Specialists ( Site 0106), Atlanta

35001

Hospital Insular de Gran Canaria ( Site 2402), Las Palmas de Gran Canaria

40503

Baptist Health Lexington-Research ( Site 0108), Lexington

44195

Cleveland Clinic-Taussig Cancer Center ( Site 0116), Cleveland

46845

Parkview Research Center at Parkview Regional Medical Center ( Site 0130), Fort Wayne

53100

ospedale le scotte-U.O.C. Immunoterapia Oncologica ( Site 2300), Siena

68130

Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0122), Omaha

Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0129), Omaha

80045

University of Colorado Anschutz Medical Campus ( Site 0104), Aurora

85234

Banner MD Anderson Cancer Center ( Site 0102), Gilbert

197758

"GBUZ SPb CRPCstmc(o) ( Site 2705)", Saint Petersburg

N.N.Petrov Research Institute of Oncology-Department of Chemotherapy and Innovative Technologies ( S, Saint Petersburg

Scientific research institution of oncology named after N.N. Petrov-Thoracic oncology ( Site 2704), Saint Petersburg

660133

Krasnoyarsk Regional Oncology Dispensary, Named after Krizhanovsky ( Site 2708), Krasnoyarsk

3109601

Rambam Health Care Campus-Oncology ( Site 2600), Haifa

4428164

Meir Medical Center ( Site 2601), Kfar Saba

4941492

Rabin Medical Center-Oncology ( Site 2604), Petah Tikva

5262100

Sheba Medical Center-ONCOLOGY ( Site 2603), Ramat Gan

9103102

Shaare Zedek Medical Center ( Site 2602), Jerusalem

L8V 4X2

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 2003), Hamilton

K7L 2V7

Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 2005), Kingston

H3T 1M5

St. Marys Hospital Center ( Site 2000), Montreal

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier, Warsaw

10-357

Samodzielny Publiczny Zespó Grulicy i Chorób Puc w Olsztynie-Oddzial Onkologii z Pododdzialem Chemi, Olsztyn

03080

Seoul National University Hospital ( Site 1101), Seoul

03722

Severance Hospital, Yonsei University Health System-Medical oncology ( Site 1105), Seoul

05505

Asan Medical Center-Department of Oncology ( Site 1103), Seoul

06351

Samsung Medical Center ( Site 1100), Seoul

08908

Instituto Catalan de Oncologia - Hospital Duran i Reynals ( Site 2403), L'Hospitalet de Llobregat

08035

Hospital Universitari Vall d'Hebron-Oncology ( Site 2401), Barcelona

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY