Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

PHASE2RecruitingINTERVENTIONAL
Enrollment

322

Participants

Timeline

Start Date

August 12, 2021

Primary Completion Date

June 4, 2029

Study Completion Date

June 4, 2029

Conditions
Pheochromocytoma/ParagangliomaPancreatic Neuroendocrine TumorVon Hippel-Lindau DiseaseAdvanced Gastrointestinal Stromal TumorHIF-2α Mutated Cancers
Interventions
DRUG

Belzutifan

Belzutifan, 120 mg, oral, once daily (QD) until progressive disease or discontinuation.

Trial Locations (83)

1083

RECRUITING

Semmelweis University-Belgyógyászati és Onkológiai Klinika Hematológia Osztály ( Site 0600), Budapest

2031

RECRUITING

Prince of Wales Hospital-Medical Oncology ( Site 1601), Randwick

2100

RECRUITING

Rigshospitalet ( Site 0304), Copenhagen

RECRUITING

Rigshospitalet-Department of Endocrinology ( Site 0303), Copenhagen

3050

RECRUITING

The Royal Melbourne Hospital ( Site 1602), Parkville

5000

RECRUITING

Odense Universitetshospital ( Site 0302), Odense C

10029

ACTIVE_NOT_RECRUITING

Icahn School of Medicine at Mount Sinai ( Site 0123), New York

10117

RECRUITING

Charité Universitaetsmedizin Berlin - Campus Mitte-Department of Endocrinology and Metabolism ( Site 0503), Berlin

13009

COMPLETED

Institut Paoli-Calmettes-Oncology ( Site 0406), Marseille

19104

RECRUITING

Penn Medicine: University of Pennsylvania Health System-Heme/Onc ( Site 0127), Philadelphia

20132

COMPLETED

Ospedale San Raffaele-Oncologia Medica ( Site 0705), Milan

20133

RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori-S.C. Oncologia Medica 2- Sarcomi ( Site 0709), Milan

20141

RECRUITING

Istituto Europeo di Oncologia IRCCS-Divisione di Oncologia Medica Gastrointestinale e Tumori Neuroe ( Site 0700), Milan

20892

RECRUITING

National Institutes of Health ( Site 0125), Bethesda

21287

RECRUITING

Johns Hopkins Hospital-Sidney Kimmel Comprehensive Cancer Center - Developmental Therapeutics ( Site 0108), Baltimore

25123

RECRUITING

Azienda Ospedaliera Spedali Civili di Brescia-Oncology ( Site 0701), Brescia

28033

COMPLETED

MD Anderson Cancer Center-Oncology ( Site 1102), Madrid

28041

ACTIVE_NOT_RECRUITING

Hospital Universitario 12 de Octubre-Medical Oncology ( Site 1103), Madrid

33011

RECRUITING

Hospital Universitario Central de Asturias-Medical Oncology ( Site 1101), Oviedo

34668

COMPLETED

Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 0902), Istanbul

35100

RECRUITING

Ege University Medicine of Faculty ( Site 0900), Bornova

37134

RECRUITING

Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Roma ( Site 0703), Verona

37203

RECRUITING

SCRI Oncology Partners ( Site 7000), Nashville

37232

RECRUITING

Vanderbilt University Medical Center ( Site 0107), Nashville

40138

RECRUITING

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 0708), Bologna

40225

RECRUITING

Universitaetsklinikum Duesseldorf-Gastroenterology, Hepatology and Infectiology ( Site 0505), Düsseldorf

48109

RECRUITING

University of Michigan ( Site 0126), Ann Arbor

52242

RECRUITING

University of Iowa ( Site 0104), Iowa City

53100

RECRUITING

Azienda Ospedaliero Universitaria Senese-U.O.C. Immunoterapia Oncologica ( Site 0706), Siena

60611

RECRUITING

Northwestern University - Robert H. Lurie Comprehensive Cancer Center ( Site 0130), Chicago

63110

ACTIVE_NOT_RECRUITING

Washington University-Internal Medicine/Oncology ( Site 0124), St Louis

67098

RECRUITING

CHU Strasbourg-Hautepierre-Medecine Interne, Endocrinologie et Nutrition ( Site 0402), Strasbourg

69003

RECRUITING

Hôpital Edouard Herriot-oncologie ( Site 0405), Lyon

75014

RECRUITING

Hopitaux Universitaires Paris Centre-Hopital Cochin ( Site 0404), Paris

77030

RECRUITING

University of Texas MD Anderson Cancer Center ( Site 0112), Houston

79106

RECRUITING

Universitaetsklinikum Freiburg ( Site 0504), Freiburg

80100

COMPLETED

University of Naples Federico II-Dipartimento di Medicina Clinica e Chirurgia ( Site 0704), Naples

80336

COMPLETED

Klinikum der Ludwig-Maximilians-Universitaet Muenchen-Department of Internal Medicine IV, Division ( Site 0501), München

90048

RECRUITING

Cedars-Sinai Medical Center ( Site 0110), Los Angeles

94270

RECRUITING

Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre ( Site 0407), Le Kremlin-Bicêtre

94805

RECRUITING

Gustave Roussy ( Site 0403), Villejuif

97080

RECRUITING

Comprehensive Cancer Center Mainfranken-Div. of Endocrinology and Diabetes ( Site 0500), Würzburg

100034

ACTIVE_NOT_RECRUITING

Peking University First Hospital-Urology ( Site 1900), Beijing

115522

RECRUITING

Fed State Budgetary Inst N.N. Blokhin Med Center of Oncology MHRF ( Site 0801), Moscow

117036

COMPLETED

Endocrinology Research Center of Rosmedtechnologies-Surgery ( Site 0809), Moscow

168583

RECRUITING

National Cancer Centre Singapore ( Site 1700), Singapore

190020

COMPLETED

Saint Petersburg State University-Clinic of advanced medical technologies n. a. Nicolay I. Pirogov ( Site 0805), Saint Petersburg

198255

RECRUITING

Saint-Petersburg City Clinical Oncology Dispensary-Department of chemotherapy ( Site 0803), Saint Petersburg

200001

ACTIVE_NOT_RECRUITING

Renji Hospital Shanghai Jiao Tong University School of Medicine ( Site 1904), Shanghai

450054

RECRUITING

GBUZ Republican Clinical Oncological Dispensary ( Site 0804), Ufa

510700

RECRUITING

Sun Yat-sen University Cancer Center ( Site 1905), Guangzhou

610041

COMPLETED

West China Hospital of Sichuan University ( Site 1906), Chengdu

5262100

RECRUITING

Sheba Medical Center-Institute of Endocrinology, Diabetes and Metabolism ( Site 1400), Ramat Gan

6423906

RECRUITING

Sourasky Medical Center ( Site 1401), Tel Aviv

7500921

RECRUITING

FALP ( Site 2200), Santiago

7560908

RECRUITING

Centro de Oncología de Precisión ( Site 2203), Santiago

02114

RECRUITING

Massachusetts General Hospital ( Site 0111), Boston

T2N 5G2

RECRUITING

Arthur J.E. Child Comprehensive Cancer Centre ( Site 0203), Calgary

M5G 2M9

RECRUITING

Princess Margaret Cancer Centre ( Site 0202), Toronto

060-8648

ACTIVE_NOT_RECRUITING

Hokkaido University Hospital ( Site 1800), Sapporo

236-0004

ACTIVE_NOT_RECRUITING

Yokohama City University Hospital ( Site 1804), Yokohama

783-8505

ACTIVE_NOT_RECRUITING

Kochi Medical School Hospital ( Site 1807), Nankoku

104-0045

ACTIVE_NOT_RECRUITING

National Cancer Center Hospital ( Site 1802), Chuo-ku

606-8507

ACTIVE_NOT_RECRUITING

Kyoto University Hospital ( Site 1806), Kyoto

123-8558

ACTIVE_NOT_RECRUITING

Tokyo Women's Medical University Adachi Medical Center ( Site 1803), Tokyo

3584 CX

RECRUITING

Universitair Medisch Centrum Utrecht ( Site 1530), Utrecht

0424

RECRUITING

Oslo Universitetssykehus Radiumhospitalet ( Site 2400), Oslo

1649-035

RECRUITING

START Lisbon - Hospital de Santa Maria ( Site 2601), Lisbon

4200-072

RECRUITING

Instituto Portugues de Oncologia Do Porto Francisco Gentil E.P.E. ( Site 2600), Porto

03080

RECRUITING

Seoul National University Hospital ( Site 2001), Jongno-gu

05505

RECRUITING

Asan Medical Center ( Site 2000), Songpa-gu

08035

RECRUITING

Hospital Universitari Vall d'Hebron ( Site 1100), Barcelona

221 85

RECRUITING

Skanes University Hospital Lund ( Site 1200), Lund

171 76

COMPLETED

Karolinska Universitetssjukhuset Solna ( Site 1202), Stockholm

751 85

RECRUITING

Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 1201), Uppsala

413 45

RECRUITING

Sahlgrenska Universitetssjukhuset-Department of Oncology CTU Clinical Trial Unit ( Site 1204), Gothenburg

01250

RECRUITING

Baskent University Adana Training Hospital ( Site 0906), Yüreğir

06230

RECRUITING

Hacettepe Universitesi-oncology hospital ( Site 0901), Ankara

06800

RECRUITING

Ankara Bilkent Şehir Hastanesi. ( Site 0904), Ankara

CB2 2QQ

RECRUITING

Addenbrooke's Hospital ( Site 1309), Cambridge

NW3 2QG

COMPLETED

Royal Free Hospital ( Site 1302), London

G12 0YN

RECRUITING

The Beatson West of Scotland Cancer Centre ( Site 1308), Glasgow

W12 OHS

RECRUITING

Hammersmith Hospital-Medical Oncology ( Site 1304), London

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY