Fluoropyrimidine Tailored-dose Based on Uracil Concentration in Patients Treated for Digestive Carcinomas: Evaluation of Clinical Practice

CompletedOBSERVATIONAL
Enrollment

334

Participants

Timeline

Start Date

November 2, 2020

Primary Completion Date

February 10, 2021

Study Completion Date

April 15, 2021

Conditions
Digestive Carcinoma
Interventions
DRUG

Fluoropyrimidine treatment (5-FU or capecitabine) and dosage

In each group with an uracil dosage; at cycle 1; capecitabine or continuous 5-FU dose percentage will be evaluate retrospectively in our database

OTHER

Uracil dosage

For each patient, uracil concentration will be evaluate and patients will be compared based on 16 ng/mL as threshold.

BEHAVIORAL

Overall survival

For each group of patient, on 16 ng/mL as threshold for uracil concentration, overall survival will be compared betwen the two groups of patients (Uracil \<16 vs Uracil ≥16).

Trial Locations (3)

69003

Hopital Edouard Heriot, Centre Hospitalier de Lyon Sud [Lyon], Hopital de la Croix Rousse [Lyon], Lyon

69004

Hopital de la Croix Rousse, Lyon

69495

Centre Hospitalier de Lyon Sud, Pierre-Bénite

All Listed Sponsors
lead

Hospices Civils de Lyon

OTHER

NCT04918264 - Fluoropyrimidine Tailored-dose Based on Uracil Concentration in Patients Treated for Digestive Carcinomas: Evaluation of Clinical Practice | Biotech Hunter | Biotech Hunter