Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic Cardiomyopathy

NAWithdrawnINTERVENTIONAL
0
Timeline

Start Date

November 30, 2021

Primary Completion Date

May 31, 2022

Study Completion Date

May 31, 2022

Conditions
Hypertrophic CardiomyopathyHypertrophic Obstructive CardiomyopathyCardiomyopathy, Hypertrophic
Interventions
OTHER

Squat-to-stand maneuver

Subjects will squat for 5 seconds and then stand. The squat-to-stand exercise will be done up to 10 times, and then immediately undergo echocardiographic imaging.

DRUG

Amyl nitrite inhalation

Subjects will inhale amyl nitrite prior to undergoing echocardiographic imaging. This is administered according to current laboratory protocol and is part of standard of care. This is an FDA-regulated drug that will be used as a control and will not be studied experimentally.

OTHER

Valsalva

Subjects will undergo echocardiographic imaging while performing the Valsalva maneuver. This is according to current laboratory protocol and is part of standard of care.

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Mayo Clinic

OTHER

NCT04905173 - Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic Cardiomyopathy | Biotech Hunter | Biotech Hunter