NCT04898114View on ClinicalTrials.gov

Nebulized Magnesium Sulfate and Sildenafil for Persistent Pulmonary Hypertension of Newborn

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

June 2, 2021

Primary Completion Date

April 30, 2025

Study Completion Date

June 1, 2025

Conditions
Persistent Pulmonary Hypertension of Newborn
Interventions
DRUG

Magnesium sulfate

Nebulized magnesium sulfate (4 ml of 6.4% solution) every 15 minutes

DRUG

Sildenafil Citrate

Oral sildenafil citrate at an initial dose of 1 mg/kg, with incremental increases by 0.5 mg/kg every 6 hours till reaching a target dose of 2mg/kg every 6 hours.

OTHER

Isotonic saline

Nebulized isotonic saline (4 ml) every 15 minutes

Trial Locations (1)

82524

RECRUITING

Neonatal Intensive Care Unit, Sohag University Hospital, Sohag

All Listed Sponsors
lead

Sohag University

OTHER