Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)

Medizinische Universität Wien ( Site 1601), Vienna

Hospital Británico de Buenos Aires-Oncology ( Site 0404), Ciudad Autónoma de Buenos Aires

East Avenue Medical Center ( Site 0802), Quezon City

CARDINAL SANTOS MEDICAL CENTER-Research Room ( Site 0800), San Juan City

Centro de Oncología e Investigación de Buenos Aires ( Site 0400), Berazategui

Sanatorio de La Mujer ( Site 0405), Rosario

Macquarie University-MQ Health Clinical Trials Unit ( Site 2102), Macquarie Park

Westmead Hospital-Department of Medical Oncology ( Site 2101), Westmead

Landesklinikum Wiener Neustadt-Innere Medizin, Hämatologie und internistische Onkologie ( Site 1604), Wiener Neustadt

Frankston Hospital-Oncology and Haematology ( Site 2103), Frankston

Hospital Italiano de Córdoba ( Site 0409), Córdoba

Uniklinikum Salzburg-Universitätsklinik für Innere Medizin III der PMU mit Hämatologie, internistis, Salzburg

Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 2804), Kecskemét

Breast Cancer Research Centre-WA ( Site 2104), Nedlands

Medizinische Universitaet Innsbruck ( Site 1602), Innsbruck

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Onkoterapias Klinika ( Site 2805), Szeged

Pécsi Tudományegyetem Klinikai Központ-Onkoterápiás Intézet ( Site 2807), Pécs

Medizinische Universität Graz-Innere Medizin Klin. Abt. Onkologie ( Site 1609), Graz

National Cancer Center-Center for Breast Cancer ( Site 2404), Goyang-si

Hematology Oncology Associates of Rockland ( Site 0044), Nyack

Vivantes Klinikum Am Urban-Haematologie und Onkologie ( Site 1203), Berlin

Hospital Pulau Pinang ( Site 2504), George Town

Institut Paoli-Calmettes ( Site 0913), Marseille

Seoul National University Bundang Hospital ( Site 2406), Seongnam

Broome Oncology ( Site 0018), Johnson City

Centre François Baclesse ( Site 0920), Caen

Georgetown University Medical Center-Department of Medicine and Oncology ( Site 0026), Washington D.C.

MedStar Washington Hospital Center ( Site 0063), Washington D.C.

Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1114), Rozzano

Ospedale San Raffaele-Oncologia Medica ( Site 1110), Milan

Istituto Europeo di Oncologia IRCCS-Divisione di Senologia Medica ( Site 1111), Milan

Ospedale San Gerardo-ASST Monza-Research Unit Phase 1 ( Site 1115), Monza

Greater Baltimore Medical Center-Medical Oncology/Hematology ( Site 0062), Baltimore

MFSMC-HJWCI ( Site 0064), Baltimore

MedStar Good Samaritan Hospital-Oncology Research ( Site 0069), Baltimore

Bon Secours St. Francis Medical Center-Oncology Research ( Site 0020), Midlothian

CHU Besançon ( Site 0918), Besançon

Waverly Hematology Oncology ( Site 0015), Cary

HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 1333), Madrid

Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 1320), Madrid

HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 1323), Pozuelo de Alarcón

St Francis Cancer Center ( Site 0058), Greenville

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 0028), Marietta

University Cancer & Blood Center, LLC ( Site 0032), Athens

Centro Estatal de Cancerologia-Investigación ( Site 0256), Chihuahua City

Institut Claudius Regaud ( Site 0902), Toulouse

Baptist MD Anderson Cancer Center ( Site 0013), Jacksonville

Miami Cancer Institute at Baptist Health, Inc. ( Site 0070), Miami

Miami Cancer Institute - Plantation ( Site 0076), Plantation

Centre de Cancérologie du Grand Montpellier ( Site 0912), Montpellier

Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 2012), Istanbul

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 2005), Istanbul

Ege University Medicine of Faculty ( Site 2004), Bornova

Istituto Oncologico Veneto IRCCS ( Site 1117), Padua

University of Tennessee Medical Center ( Site 0039), Knoxville

Universitaetsklinikum Duesseldorf-Klinik für Frauenheilkunde & Geburtshilfe ( Site 1204), Düsseldorf

Hospital Civil Fray Antonio Alcalde-Oncology ( Site 0262), Guadalajara

İnönü Üniversitesi Turgut Özal Tıp Merkezi Eğitim ve Araştırma Hastanesi-Medical Oncology Department, Malatya

Institut de Cancérologie de l'Ouest ( Site 0907), Saint-Herblain

Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung-Klinike für Senologie/ Brustzentrum ( Site 1200, Essen

Fundación Instituto Valenciano de Oncología-Oncologico ( Site 1332), Valencia

Parkview Research Center at Parkview Regional Medical Center ( Site 0071), Fort Wayne

Henry Ford Hospital ( Site 0003), Detroit

Institut de Cancérologie de l'Ouest ( Site 0915), Angers

Hospital Kuala Lumpur-Radiotherapy and Oncology ( Site 2506), Kuala Lumpur

Gynaekologisches Zentrum Bonn ( Site 1201), Bonn

Sanford Cancer Center ( Site 0021), Sioux Falls

Sanford Fargo Medical Center ( Site 0040), Fargo

Centre Oscar Lambret ( Site 0921), Lille

University Malaya Medical Centre ( Site 2505), Lembah Pantai

Pantai Hospital Kuala Lumpur-Cancer Centre ( Site 2503), Kuala Lumpur

Orchard Healthcare Research Inc. ( Site 0037), Skokie

Edward-Elmhurst Healthcare, Elmhurst Hospital-Nancy W. Knowles Cancer Center ( Site 0067), Elmhurst

Edward-Elmhurst Healthcare, Edward Hospital-Edward Cancer Center ( Site 0066), Naperville

Edward-Elmhurst Healthcare, Edward Hospital - Plainfield-Edward Cancer Center - Plainfield ( Site 00, Plainfield

University of Illinois at Chicago ( Site 0061), Chicago

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 0901), Clermont-Ferrand

Filios Alta Medicina ( Site 0253), Monterrey

Centro de Investigacion Clinica de Oaxaca ( Site 0252), Oaxaca City

Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0009), Omaha

CENTRE LEON BERARD ( Site 0919), Lyon

Instituto Tumori Giovanni Paolo II-ONCOLOGIA MEDICA ( Site 1112), Bari

Louisiana State University Health Sciences Shreveport ( Site 0072), Shreveport

CHRISTUS Highland-Oncology Research ( Site 0073), Shreveport

Institut Curie ( Site 0900), Paris

Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen ( Site 0904), Rouen

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1116), Napoli

Arizona Oncology Associates-Arizona Oncology ( Site 0049), Tucson

Centre Hospitalier Universitaire de Poitiers-Pôle régional de cancérologie ( Site 0922), Poitiers

Universitaetsklinikum Erlangen-Klinik für Gynäkologie und Geburtshilfe ( Site 1202), Erlangen

Sarawak General Hospital-Radiotherapy Unit ( Site 2501), Kuching

Pacific Cancer Care ( Site 0023), Monterey

UCSF Medical Center at Mission Bay ( Site 0043), San Francisco

Gustave Roussy ( Site 0914), Villejuif

Ospedale Cannizzaro ( Site 1118), Catania

Providence Portland Medical Center ( Site 0038), Portland

Northwest Medical Specialties, PLLC ( Site 0008), Tacoma

North Star Lodge ( Site 0035), Yakima

Medical Oncology Associates, PS ( Site 0010), Spokane

Kadlec Clinic Hematology and Oncology ( Site 0055), Kennewick

Cancer Hospital Chinese Academy of Medical Science ( Site 2635), Beijing

Beijing Cancer hospital-Department of Breast Cancer ( Site 2605), Beijing

Beijing Peking Union Medical College Hospital-Medical Oncology ( Site 2610), Beijing

Moscow Clinical Research Center-Chemotherapy department ( Site 1903), Moscow

Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia ( Site 0607), Bogotá

Fed State Budgetary Inst N.N. Blokhin Med Center of Oncology MHRF ( Site 1901), Moscow

Central Clinical Hospital of the Presidential Administrative Department ( Site 1904), Moscow

Jilin Cancer Hospital-oncology department ( Site 2619), Changchun

Podolsk Regional Clinical Hospital ( Site 1907), Podolsk

Arkhangelsk Clinical Oncological Dispensary-Chemotherapy department ( Site 1902), Arkhangelsk

St. Petersburg Clinical Hospital of Russian Academy Of Sciences-Medical Oncology ( Site 1905), Saint Petersburg

N.N.Petrov Research Institute of Oncology ( Site 1900), Saint Petersburg

Sociedad De Oncologia Y Hematologia Del Cesar-Oncology ( Site 0603), Valledupar

Fudan University Shanghai Cancer Center-Oncology ( Site 2600), Shanghai

Renji Hospital Shanghai Jiao Tong University School of Medicine-Breast surgery ( Site 2626), Shanghai

"Centrul de Oncologie Sfântul Nectarie-Medical Oncology ( Site 2901)", Craiova

Jiangsu provincial people's hospital-Oncology Department ( Site 2607), Nanjing

Oncomedica S.A.-Oncomedica S.A ( Site 0604), Montería

Anhui Cancer Hospital-medical oncology ( Site 2632), Hefei

Shandong Cancer Hospital-Breast surgery ( Site 2623), Jinan

Tianjin Medical University Cancer Institute and Hospital-Department of Breast Cancer ( Site 2612), Tianjin

Zhejiang Cancer Hospital-Breast Oncology ( Site 2622), Hangzhou

Taizhou Hospital of Zhejiang Province ( Site 2636), Linhai

The First Affiliated Hospital of Wenzhou Medical University-Thyroid and breast surgery ( Site 2625), Wenzhou

The Third Hospital of Nanchang-Oncology Dept ( Site 2628), Nanchang

The First Affiliated hospital of Xiamen University-Breast Surgery ( Site 2613), Xiamen

Ryazan Regional Clinical Oncology Center-Oncology #1 ( Site 1906), Ryazan

Cardiomed SRL Cluj-Napoca ( Site 2902), Cluj-Napoca

Institutul Oncologic-Day Hospital Unit ( Site 2905), Cluj-Napoca

Xiangya Hospital Central South University-Breast department ( Site 2621), Changsha

Hunan Cancer Hospital ( Site 2608), Changsha

Wuhan Union Hospital Cancer Center-Cancer Center ( Site 2629), Wuhan

Oncopremium Team-Oncology ( Site 2903), Baia Mare

Henan Cancer Hospital-Galactophore Department ( Site 2615), Zhengzhou

SUN YAT-SEN UNIVERSITY CANCER CENTRE-oncology breast ( Site 2616), Guangzhou

Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Breast Oncology Center ( Site 2641), Guangzhou

Peking University Shenzhen Hospital-Oncology Department ( Site 2601), Shenzhen

The First People's Hospital of Foshan-Oncology Department of Breast Cancer ( Site 2620), Foshan

Guangxi Medical University Affiliated Tumor Hospital-Oncology Dept. of Breast and Bone Soft Tissue (, Nanning

Nizhegorodsky Regional Oncology Dispensary-chemotherapy ( Site 1912), Nizhny Novgorod

West China Hospital Sichuan University-Head and Neck Oncology ( Site 2630), Chengdu

The First Affiliated Hospital of Xian Jiaotong University wa-Oncology ( Site 2604), Xi'an

Sigmedical Services SRL ( Site 2904), Suceava

Xinjiang Medical University Cancer Hospital - Urumqi-galactophore department ( Site 2624), Ürümqi

Bnai Zion Medical Center-Oncology ( Site 1704), Haifa

Centro Investigación del Cáncer James Lind ( Site 0513), Temuco

Sheba Medical Center-ONCOLOGY ( Site 1700), Ramat Gan

Sourasky Medical Center-Oncology ( Site 1701), Tel Aviv

FALP ( Site 0501), Santiago

Oncovida ( Site 0514), Santiago

Clínica RedSalud Vitacura ( Site 0515), Santiago

Assuta Ashdod Medical Center ( Site 1703), Ashdod

Instituto Nacional del Cancer-CR Investigación ( Site 0511), Santiago

Soroka Medical Center-Oncology ( Site 1702), Beersheba

Bradfordhill ( Site 0500), Santiago

Instituto Nacional de Câncer - INCA-Pesquisa Clinica HC3 ( Site 0208), Rio de Janeiro

YNOVA Pesquisa Clínica ( Site 0203), Florianópolis

University of Alabama at Birmingham-Medicine ( Site 0065), Birmingham

McFarland Clinic, PC ( Site 0041), Ames

New England Cancer Specialists ( Site 0007), Scarborough

University of Massachusetts Medical School-Division of Hematology/Oncology ( Site 0052), Worcester

Oregon Health and Science University ( Site 0031), Portland

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0412), Mar del Plata

Hospital Aleman-Oncology ( Site 0402), Buenos Aires

Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 0403), Buenos Aires

Sanatorio Parque ( Site 0407), Rosario

Instituto de Oncología de Rosario ( Site 0401), Rosario

Fundación CEMAIC ( Site 0410), Córdoba

Instituto San Marcos ( Site 0408), San Juan

Hospital de Câncer de Recife ( Site 0211), Recife

Instituto de Oncologia Saint Gallen ( Site 0206), Santa Cruz do Sul

Clínica de Oncologia Reichow ( Site 0210), Blumenau

Instituto de Educação, Pesquisa e Gestão em Saúde ( Site 0202), Rio de Janeiro

Tom Baker Cancer Center ( Site 0107), Calgary

North York General Hospital ( Site 0108), Toronto

Princess Margaret Cancer Centre ( Site 0101), Toronto

Centre Hospitalier de l'Université de Montréal ( Site 0105), Montreal

Jewish General Hospital ( Site 0110), Montreal

Hopital Du Saint-Sacrement ( Site 0109), Québec

Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec (, Trois-Rivières

Fundación Colombiana de Cancerología Clínica Vida ( Site 0605), Medellín

Instituto de Cancerología-Oncology ( Site 0606), Medellín

Clinica de la Costa S.A.S. ( Site 0601), Barranquilla

Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Frauenheilkunde und Gebur, Dresden

General Hospital of Athens Laiko-First Department of Internal Medicine ( Site 0305), Athens

Alexandra Hospital-ONCOLGOY DEPT. ( Site 0302), Athens

Hygeia Hospital-3rd Oncology Department ( Site 0304), Marousi

University General Hospital of Heraklion-Internal Medicine-Oncology ( Site 0303), Heraklion

Euromedica General Clinic Thessaloniki-Oncology Unit ( Site 0301), Thessaloniki

CELAN,S.A ( Site 0151), Guatemala City

Gastrosoluciones ( Site 0156), Guatemala City

INTEGRA Cancer Institute ( Site 0155), Guatemala City

Centro Medico Integral De Cancerología (CEMIC) ( Site 0154), Quetzaltenango

St. James's Hospital ( Site 1530), Dublin

St. Vincent's University Hospital-Medical Oncology Research Department ( Site 1531), Dublin

Fondazione Policlinico Universitario Agostino Gemelli-Medical Oncology ( Site 1113), Rome

Hyogo Medical University Hospital ( Site 2201), Nishinomiya

St. Marianna University School of Medicine Hospital ( Site 2205), Kawasaki

Kitasato University Hospital ( Site 2204), Sagamihara

Osaka University Hospital ( Site 2211), Suita

Saitama Medical University International Medical Center ( Site 2208), Hidaka

Tokyo Medical University Hospital ( Site 2206), Shinjuku-ku

Chiba University Hospital ( Site 2212), Chiba

National Hospital Organization Kyushu Cancer Center ( Site 2209), Fukuoka

Fukushima Medical University ( Site 2200), Fukushima

Kumamoto University ( Site 2203), Kumamoto

St. Luke's International Hospital ( Site 2207), Tokyo

Juntendo University Hospital ( Site 2210), Tokyo

Samadhi Centro Oncológico ( Site 0258), Mexico City

Radboudumc-Medical Oncology ( Site 1360), Nijmegen

Maastricht UMC+-Medical Oncology ( Site 1353), Maastricht

Jeroen Bosch Hospital ( Site 1359), 's-Hertogenbosch

Elisabeth-TweeSteden Ziekenhuis-Internal Medicine ( Site 1357), Tilburg

Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL) ( Site 1351), Amsterdam

Leids Universitair Medisch Centrum-Medical Oncology ( Site 1356), Leiden

Haaglanden MC - locatie Antoniushove-Medical oncology ( Site 1355), Leidschendam

Franciscus Gasthuis & Vlietland, Locatie Vlietland ( Site 1354), Schiedam

Meander Medisch Centrum ( Site 1358), Amersfoort

Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1813), Bydgoszcz

Pratia MCM Krakow ( Site 1809), Krakow

Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 1818), Siedlce

Luxmed Onkologia sp. z o. o. ( Site 1820), Warsaw

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Piersi i Chirurgii (, Warsaw

Lux med onkologia sp. z o.o. ( Site 1808), Warsaw

Wojskowy Instytut Medyczny-Klinika Onkologii ( Site 1803), Warsaw

Mazowiecki Szpital Onkologiczny-BREAST CANCER ( Site 1821), Wieliszew

Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1819), Przemyśl

Bialostockie Centrum Onkologii-Oddzial Onkologii Klinicznej ( Site 1812), Bialystok

Narodowy Instytut Onkologii - Oddzial w Gliwicach-Breast Unit ( Site 1811), Gliwice

Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 1815), Koszalin

Champalimaud Foundation ( Site 1006), Lisbon

Centro Hospitalar Universitário Lisboa Norte, E.P.E. - Hospital de Santa Maria ( Site 1004), Lisbon

UNIDADE LOCAL DE SAUDE DE MATOSINHOS ( Site 1007), Matosinhos Municipality

Centro Hospitalar do Porto - Hospital de Santo António-Oncology Service ( Site 1003), Porto

Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 1005), Porto

Seoul National University Hospital-Internal Medicine ( Site 2403), Seoul

Severance Hospital, Yonsei University Health System ( Site 2400), Seoul

Asan Medical Center ( Site 2402), Seoul

Samsung Medical Center-Division of Hematology/Oncology ( Site 2401), Seoul

Hospital Quiron Barcelona ( Site 1326), Barcelona

Karolinska Universitetssjukhuset Solna-Tema Cancer - ME Bröst- endokrina tumörer och sarkom ( Site 1, Stockholm

Södra Älvsborg Sjukhus ( Site 1406), Borås

I.E.U. Medical Point Hastanesi-Oncology ( Site 2016), Izmir, Karsiyaka

Baskent University Dr. Turgut Noyan Research and Training Center ( Site 2013), Adana

Hacettepe Universitesi-oncology hospital ( Site 2000), Ankara

Memorial Ankara Hastanesi-Medical Oncology ( Site 2002), Ankara

Gazi Universitesi-Oncology ( Site 2010), Ankara

ANKARA ŞEHİR HASTANESİ-Medical Oncology ( Site 2014), Ankara

Akdeniz Universitesi Hastanesi-Medical Oncology ( Site 2009), Antalya

The Royal Cornwall Hospital ( Site 1507), Truro

Leicester Royal Infirmary-HOPE Clinical Trials Unit ( Site 1502), Leicester

St Bartholomew's Hospital ( Site 1508), London

The Christie ( Site 1510), Manchester

Blackpool Victoria Hospital ( Site 1503), Blackpool

Guy's & St Thomas' NHS Foundation Trust ( Site 1501), London

North West Cancer Centre ( Site 1511), Londonderry