JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC

PHASE3RecruitingINTERVENTIONAL
Enrollment

500

Participants

Timeline

Start Date

January 4, 2022

Primary Completion Date

June 30, 2026

Study Completion Date

December 31, 2027

Conditions
Locally Advanced Head and Neck Squamous Cell CarcinomaAged
Interventions
DRUG

JNJ-90301900 (NBTXR3)

Suspension of inert, crystalline hafnium oxide particles, designed to generate oxygen free radicals to destroy cancer cells after activation by ionizing radiation.

DRUG

Cetuximab

Solution for infusion

RADIATION

Radiation Therapy

Intensity-modulated radiation therapy (IMRT): 70 Gray in 35 fractions over a 7-week period.

Trial Locations (171)

100

RECRUITING

National Taiwan University Hospital, Taipei

144

RECRUITING

Ltd Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic, Tbilisi

500

RECRUITING

Changhua Christian Hospital, Changhua

704

RECRUITING

National Cheng Kung University Hospital, Bei Qu

1000

RECRUITING

Manila Doctors Hospital, Manila

1062

RECRUITING

Eszak Pesti Centrumkorhaz Honvedkorhaz, Budapest

1090

RECRUITING

Medizinische Universitaet Wien, Vienna

1112

RECRUITING

St. Luke's Medical Center, Quezon City

1122

RECRUITING

Orszagos Onkologiai Intezet, Budapest

1200

RECRUITING

Cliniques Universitaires Saint Luc, Brussels

1600

RECRUITING

The Medical City, Pasig

1742

RECRUITING

University of Perpetual Help Dalta Medical Center, Inc, Las Piñas

1756

COMPLETED

Specialized Hospital for Active Treatment in Oncology, Sofia

3000

RECRUITING

Universitair Ziekenhuis Leuven, Leuven

4010

RECRUITING

Ordensklinikum Linz GmbH Barmherzige Schwestern, Linz

4500

COMPLETED

MHAT Uni Hospital, Panagyurishte

4600

RECRUITING

JSC Vian Kutaisi Referral Hospital, Kutaisi

6000

RECRUITING

High Technology Hospital MedCenter Ltd Batumi, Batumi

6060

RECRUITING

Grand Hopital De Charleroi Site Les Viviers, Charleroi

6720

RECRUITING

Szent Gyorgyi Albert Klinikai Kozpont Onkoterapias Klinika, Szeged

8035

RECRUITING

Hosp Univ Vall D Hebron, Barcelona

8036

RECRUITING

Medizinische Universitat Graz, Graz

10000

COMPLETED

Klinicki bolnicki centar Zagreb, Zagreb

10032

COMPLETED

Herbert Irving Comprehensive Cancer Center Columbia University Medical Center, New York

10310

RECRUITING

Richmond University Medical Center, Staten Island

10467

RECRUITING

Montefiore Medical Center, The Bronx

11000

COMPLETED

Institute of Oncology and Radiology of Serbia, Belgrade

COMPLETED

Vojnomedicinska Akademija, Belgrade

13385

RECRUITING

Hopital de la Timone, Marseille

14076

RECRUITING

Centre Francois Baclesse, Caen

14784

RECRUITING

Fundacao Pio Xii - Hospital De Cancer De Barretos, Barretos

16247

RECRUITING

The Catholic university of Korea, St. Vincent's Hospital, Suwon

18059

RECRUITING

Universitaetsmedizin Rostock, Rostock

19104

RECRUITING

University of Pennsylvania Perelman Center for Advanced Medicine, Philadelphia

20442

RECRUITING

Chang-Gung Memorial Hospital-Keelung, Keelung

21204

COMPLETED

Institute of Oncology of Vojvodina, Kamenitz

22328

RECRUITING

Institutul Oncologic Prof Dr Al Trestioreanu Bucuresti, Bucharest

27003

RECRUITING

Hosp. Univ. Lucus Augusti, Lugo

27514

RECRUITING

University of North Carolina at Chapel Hill, Chapel Hill

28040

RECRUITING

Hosp Univ Fund Jimenez Diaz, Madrid

28041

RECRUITING

Hosp. Univ. 12 de Octubre, Madrid

28050

RECRUITING

Hosp Univ Hm Sanchinarro, Madrid

29010

RECRUITING

Hosp Regional Univ de Malaga, Málaga

29609

RECRUITING

CHU Brest, Brest

30013

RECRUITING

Shanxi Provincial Cancer hospital, Taiyuan

30308

RECRUITING

Emory University Hospital Midtown, Atlanta

31008

TERMINATED

Hosp. de Navarra, Pamplona

33520

COMPLETED

Tampereen Yliopistollinen Sairaala, Tampere

33604

RECRUITING

Hopital Haut Leveque, Pessac

33612

RECRUITING

Moffitt Cancer Center, Tampa

34000

COMPLETED

University Clinical Center Kragujevac, Kragujevac

35000

RECRUITING

Hopital Pontchaillou, Rennes

35001

TERMINATED

Hospitales Universitarios San Roque En Las Palmas de Gran Canaria Centro Oncologico Integral Canario, Las Palmas de Gran Canaria

35392

RECRUITING

Universitaetsklinikum Giessen und Marburg GmbH, Giessen

39008

RECRUITING

Hosp. Univ. Marques de Valdecilla, Santander

40705

RECRUITING

Taichung Veterans General Hospital, Taichung

41013

RECRUITING

Hosp. Virgen Del Rocio, Seville

41110

RECRUITING

University Hospital Of Larissa, Larissa

41345

COMPLETED

Sahlgrenska Universitetssjukhuset, Gothenburg

42055

RECRUITING

CHU Saint Etienne, Saint-Etienne

45219

RECRUITING

University of Cincinnati, Cincinnati

46010

RECRUITING

Inst. Valenciano de Oncologia, Valencia

46014

RECRUITING

Hosp. Gral. Univ. Valencia, Valencia

48903

RECRUITING

Hosp. Univ. de Cruces, Barakaldo

50011

RECRUITING

The Fourth Hospital of Hebei Medical University, Shijiazhuang

54500

RECRUITING

Institut de Cancerologie de Lorraine, Vandœuvre-lès-Nancy

54639

RECRUITING

Athens Medical Center S A Interbalkan Medical Center of Thessaloniki, Thessaloniki

57001

COMPLETED

Interbalkan Medical Center of Thessaloniki, Thessaloniki

59020

RECRUITING

Centre de Lutte contre le Cancer Centre Oscar Lambret, Lille

59322

COMPLETED

Centre Hospitalier de Valenciennes Hopital Jean Bernard, Valenciennes

69008

COMPLETED

Centre Leon Berard, Lyon

73104

RECRUITING

Stephenson Cancer Center, Oklahoma City

75015

RECRUITING

Hopital Europeen Georges Pompidou, Paris

75248

RECRUITING

Institut Curie, Paris

75970

RECRUITING

Hopital Tenon, Paris

76038

RECRUITING

CLCC - Centre Henri Becquerel, Rouen

80000

RECRUITING

CHU Amiens Picardie, Amiens

81675

RECRUITING

Klinikum rechts der Isar an der Technischen Universitat Munchen, München

87505

RECRUITING

Christus St. Vincent Regional Cancer Center, Santa Fe

90095

RECRUITING

UCLA Hematology Oncology, Los Angeles

91010

RECRUITING

City of Hope, Duarte

92200

RECRUITING

Clinique Ambroise Pare, Neuilly-sur-Seine

92653

COMPLETED

Memorial Radiation Oncology Medical Group Laguna Hills, Laguna Hills

92663

RECRUITING

Hoag Memorial Hospital, Newport Beach

94158

RECRUITING

University of California San Francisco, San Francisco

94805

RECRUITING

Gustave Roussy, Villejuif

110042

COMPLETED

Liaoning Cancer Hospital and Institute, Shenyang

200032

COMPLETED

Fudan University Shanghai Cancer Center, Shanghai

210009

COMPLETED

Jiangsu Cancer Hospital, Nanjing

215004

COMPLETED

Second Affiliated Hospital, SooChow University, Suzhou

221000

COMPLETED

The Affiliated Hospital of Xuzhou Medical University, Xuzhou

223800

RECRUITING

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, Nanjing

233004

COMPLETED

The Affiliated Hospital of Bengbu Medical College, Bengbu

250012

RECRUITING

Qilu Hospital of Shandong University, Jinan

250117

RECRUITING

Shandong Cancer Hospital, Jinan

266003

RECRUITING

The Affiliated Hospital of Medical College Qingdao University, Qingdao

276002

RECRUITING

Linyi Cancer Hospital, Linyi

300060

COMPLETED

Tianjin Medical University Cancer Institute and Hospital, Tianjin

330029

COMPLETED

Jiangxi Cancer Hospital, Nanchang

350001

COMPLETED

Fujian Medical University Union Hospital, Fuzhou

350005

RECRUITING

The First Affiliated Hospital of Fujian Medical University, Fuzhou

350014

RECRUITING

Fujian Medical University Fujian Provincial Cancer Hospital, Fuzhou

361003

COMPLETED

The first affiliated hospital of xiamen university, Xiamen

400012

RECRUITING

Tata Memorial Hospital, Mumbai

410008

COMPLETED

Xiangya Hospital Central South University, Changsha

410013

RECRUITING

Hunan Cancer hospital, Changsha

422002

RECRUITING

HealthCare Global HCG Manavata Cancer Centre, Nashik

430022

RECRUITING

Union Hospital Tongji Medical College of Huazhong University of Science and Technology, Wuhan

430030

RECRUITING

Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology, Wuhan

430079

RECRUITING

Hubei Cancer Hospital, Wuhan

450008

COMPLETED

Henan Cancer Hospital, Zhengzhou

510080

RECRUITING

The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou

510095

RECRUITING

Guangzhou Medical University Affiliated Oncology Hospital, Guangzhou

510180

RECRUITING

Guangzhou First Municipal People's Hospital, Guangzhou

518036

RECRUITING

Peking University Shenzhen Hospital, Shenzhen

519000

RECRUITING

The Fifth Affiliated Hospital Sun Yat Sen University, Zhuhai

523109

RECRUITING

Dongguan People s Hospital, Dongguan

530000

RECRUITING

Wuming Hospital of Guangxi Medical University, Nanning

530021

RECRUITING

The Cancer Hospital Affiliated to Guangxi Medical University, Nanning

545006

RECRUITING

Liuzhou people's Hospital, Liuzhou

560054

RECRUITING

M S Ramaiah Memorial Hospital, Bangalore

600035

COMPLETED

Apollo Speciality Hospital, Chennai, Chennai

610041

RECRUITING

Sichuan Cancer Hospital, Chengdu

625107

COMPLETED

Meenakshi Mission Hospital and Research Center, Madurai

1998050

RECRUITING

Hosp. Cuf Descobertas, Lisbon

3109601

RECRUITING

Rambam Health Care Campus, Haifa

6423906

RECRUITING

Tel Aviv Sourasky Medical Center, Tel Aviv

7747629

RECRUITING

Samson Assuta Ashdod University Hospital, Ashdod

9112001

SUSPENDED

Hadassah Medical Center, Jerusalem

17210120

RECRUITING

Hospital Amaral Carvalho, Jaú

30380 472

RECRUITING

Nucleo de Ensino e Pesquisa do Instituto Mario Penna, Belo Horizonte

60336 232

RECRUITING

Centro Regional Integrado de Oncologia CRIO, Fortaleza

60430-230

RECRUITING

Hospital Haroldo Juaçaba - Instituto do Câncer do Ceará, Fortaleza

35160 158

RECRUITING

Fundacao Sao Francisco Xavier, Ipatinga

86015 520

RECRUITING

Hospital do Cancer de Londrina, Londrina

90610-000

RECRUITING

Hospital Sao Lucas da PUCRS, Porto Alegre

91350-200

RECRUITING

Hospital Nossa Senhora da Conceicao, Porto Alegre

22250-905

RECRUITING

Grupo Oncoclinicas - Botafogo, Rio de Janeiro

15090-000

RECRUITING

Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto

01308-050

RECRUITING

Hospital Sirio Libanes Sao Paulo, São Paulo

90050-170

RECRUITING

Irmandade da Santa Casa de Misericordia de Porto Alegre, São Paulo

29043 260

RECRUITING

Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia, Vitória

779 00

RECRUITING

Fakultni nemocnice Olomouc, Olomouc

180 81

RECRUITING

Nemocnice Bulovka, Prague

0112

COMPLETED

Todua Clinic, Tbilisi

07747

RECRUITING

Universitatsklinikum Jena, Jena

124 62

RECRUITING

General Hospital of Athens Attikon, Athens

411 001

COMPLETED

Grant Medical foundation Ruby Hall Clinic, Pune

113-8519

RECRUITING

Tokyo Medical and Dental University Hospital, Bunkyō City

734 8551

RECRUITING

Hiroshima University Hospital, Hiroshima

277-8577

RECRUITING

National Cancer Center Hospital East, Kashiwa

464-8681

RECRUITING

Aichi Cancer Center, Nagoya

541 8567

RECRUITING

Osaka International Cancer Institute, Osaka

589 8511

COMPLETED

Kindai University Hospital, Osaka Sayama Shi

980-8574

RECRUITING

Tohoku University Hospital, Sendai

329-0498

RECRUITING

Jichi Medical University Hospital, Shimotsuke

160 0023

RECRUITING

Tokyo Medical University Hospital, Shinjuku

411 8777

RECRUITING

Shizuoka Cancer Center, Sunto Gun

4710 243

COMPLETED

Uls Braga - Hosp. Braga, Braga

1649 035

COMPLETED

Uls Santa Maria - Hosp. Santa Maria, Lisbon

4099-001

COMPLETED

Uls Santo Antonio - Hosp. Santo Antonio, Porto

4434 502

RECRUITING

Uls Gaia Espinho, Vila Nova de Gaia

03722

RECRUITING

Severance Hospital, Seoul

06591

RECRUITING

The Catholic University of Korea Seoul St Mary s Hospital, Seoul

138 736

RECRUITING

Asan Medical Center (AMC), Seoul

08036

RECRUITING

Hosp Clinic de Barcelona, Barcelona

08908

RECRUITING

Instituto Catalan Deoncologia Hospital Duran I Reynals, L'Hospitalet de Llobregat

G12 0YN

RECRUITING

NHS Greater Glasgow and Clyde, Glasgow

GU2 7XX

RECRUITING

The Royal Surrey County Hospital NHS Foundation Trust, Guildford

SW3 6JJ

RECRUITING

The Royal Marsden NHS Foundation Trust, London

NE7 7DN

RECRUITING

Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne

All Listed Sponsors
lead

Johnson & Johnson Enterprise Innovation Inc.

INDUSTRY