Biologic Abatement and Capturing Kids' Outcomes and Flare Frequency in Juvenile Spondyloarthritis

NAActive, not recruitingINTERVENTIONAL
Enrollment

164

Participants

Timeline

Start Date

November 11, 2021

Primary Completion Date

July 1, 2026

Study Completion Date

July 1, 2026

Conditions
Juvenile Spondyloarthritis
Interventions
OTHER

Standard TNFi Therapy

Participants randomly assigned to this arm will continue taking their TNFi medication as currently prescribed.

OTHER

TNFi fixed longer dosing intervals

"Participants randomly assigned to this arm will increase the time between TNFi medication doses.~* Adalimumab- from every 2 to 3 weeks~* Certolizumab- from every 2 to 4 weeks~* Etanercept- from every 1 to 2 weeks~* Golimumab- from every 4 to 6 weeks~* Infliximab- from baseline to baseline + 2 weeks"

OTHER

Stop TNFi treatment

Participants randomly assigned to this arm will stop TNFi medication.

Trial Locations (31)

10021

Hospital for Special Surgery, New York

11040

Cohen Children's Medical Center, Queens

15224

UPMC Children's Hospital of Pittsburgh, Pittsburgh

19104

The Children's Hospital of Philadelphia, Philadelphia

19803

Nemours Children's Hospital, Wilmington

20010

Children's National Health System, Washington D.C.

30329

Children's Healthcare of Atlanta, Atlanta

32827

Nemours Children's Health, Orlando

35294

University of Alabama at Birmingham, Birmingham

37232

Vanderbilt Children's Hospital, Nashville

43205

Nationwide Children's Hospital, Columbus

44302

Akron Children's Hospital, Akron

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

46202

Riley Hospital for Children at IU Health, Indianapolis

48109

University of Michigan, Ann Arbor

52242

University of Iowa Stead Family Children's Hospital, Iowa City

55455

University of Minnesota Masonic Children's Hospital, Minneapolis

60611

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago

63110

St. Louis Children's Hospital, St Louis

64108

Children's Mercy Hospital, Kansas City

75390

UT Southwestern Medical Center, Dallas

77030

Texas Children's Hospital - Baylor College of Medicine, Houston

80045

Children's Hospital of Colorado, Aurora

84113

Primary Children's Hospital, Salt Lake City

85006

Phoenix Children's, Phoenix

90027

Children's Hospital Los Angeles, Los Angeles

94304

Stanford University, Palo Alto

97227

Randall Children's Hospital at Legacy Emanuel, Portland

98105

Seattle Children's Hospital, Seattle

02115

Boston Children's Hospital, Boston

M5G 1E8

The Hospital for Sick Children, Toronto

All Listed Sponsors
collaborator

Patient-Centered Outcomes Research Institute

OTHER

lead

Children's Hospital of Philadelphia

OTHER