A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2

PHASE2RecruitingINTERVENTIONAL
Enrollment

372

Participants

Timeline

Start Date

May 3, 2022

Primary Completion Date

December 11, 2026

Study Completion Date

April 14, 2029

Conditions
Urothelial Carcinoma
Interventions
DRUG

disitamab vedotin

Given into the vein (IV; intravenous) every 2 weeks.

DRUG

pembrolizumab

Given by IV on Day 1 of each 6-week cycle.

Trial Locations (183)

2065

RECRUITING

GenesisCare - North Shore, St Leonards

2109

RECRUITING

Macquarie University, Sydney

3199

RECRUITING

Peninsula & South Eastern Haematology and Oncology Group, Frankston

4102

RECRUITING

Metro South Hospital and Health Service, Brisbane

RECRUITING

Princess Alexandra Hospital, Woolloongabba

5000

ACTIVE_NOT_RECRUITING

CHU UCL Namur-Site de Saint Elisabeth, Namur

5112

RECRUITING

Lyell McEwin Hospital, Elizabeth Vale

9000

ACTIVE_NOT_RECRUITING

AZ Maria Middelares, Ghent

10021

RECRUITING

Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street)., New York

10029

RECRUITING

Icahn School of Medicine at Mount Sinai, New York

10065

RECRUITING

Evelyn H. Lauder Breast and Imaging Centre (BAIC), New York

RECRUITING

Memorial Sloan Kettering Cancer Center - Main Campus, New York

RECRUITING

Sidney Kimmel Center for Prostate and Urological Cancers - Memorial Sloan Kettering Cancer Center, New York

10604

RECRUITING

MSK Wesrchester, Harrison

11042

RECRUITING

Northwell Health, Lake Success

11101

RECRUITING

Memorial Sloan Kattering Cancer Centre- Investigational Drug Service Pharmacy, Long Island City

11553

RECRUITING

MSK nassau, Uniondale

11725

RECRUITING

MSK Commack, Commack

13210

ACTIVE_NOT_RECRUITING

SUNY Upstate Medical University, Syracuse

20010

NOT_YET_RECRUITING

Medstar Washington Hospital Center, Washington D.C.

20132

ACTIVE_NOT_RECRUITING

Ospedale San Raffaele, Milan

ACTIVE_NOT_RECRUITING

IRCCS Ospedale San Raffaele, U.O. Farmacia Studi Clinici, Milan

22030

NOT_YET_RECRUITING

Trakya Universitesi Tip Fakultesi Hastanesi (Saglik Arastirma ve Uygulama Merkezi), Edirne

22031

RECRUITING

Inova Schar Cancer Institute, Fairfax

27514

NOT_YET_RECRUITING

UNC Hospitals, The University of North Carolina at Chapel Hill, Chapel Hill

27599

NOT_YET_RECRUITING

UNC Lineberger Comprehensive Cancer Center / University of North Carolina, Chapel Hill

28025

RECRUITING

Atrium Health Cabarrus (biopsy only), Concord

RECRUITING

Levine Cancer Institute Concord, Concord

28033

ACTIVE_NOT_RECRUITING

MD Anderson Cancer Center - Madrid, Madrid

ACTIVE_NOT_RECRUITING

MD Anderson Cancer Center Madrid, Madrid

28054

RECRUITING

Levine Cancer Institute- Gaston, Gastonia

28112

RECRUITING

Atrium Health Union (biopsy only), Monroe

28203

RECRUITING

Carolinas Medical Center (biopsy only), Charlotte

28204

RECRUITING

Carolinas Medical Center Investigational Drug Services, Charlotte

RECRUITING

Levine Cancer Institute, Charlotte

28207

RECRUITING

Atrium Health Mercy (biopsy only), Charlotte

28262

RECRUITING

Atrium Health University City (biopsy only), Charlotte

RECRUITING

Levine Cancer Institute University, Charlotte

28277

RECRUITING

Levine Cancer Institute - Ballantyne, Charlotte

30060

RECRUITING

Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital, Marietta

30117

RECRUITING

Northwest Georgia Oncology Centers, a Service of Tanner Medical Center Villa Rica, Carrollton

RECRUITING

West Georgia Infusion Center, a Service of Tanner Medical Center Villa Rica, Carrollton

30121

RECRUITING

Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital, Cartersville

30134

RECRUITING

Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital, Douglasville

30141

RECRUITING

Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital, Hiram

RECRUITING

WellStar Paulding Hospital, Hiram

32003

RECRUITING

Florida Cancer Specialists, Fleming Island

32117

ACTIVE_NOT_RECRUITING

Florida Cancer Specialists, Daytona Beach

32308

RECRUITING

Florida Cancer Specialists, Tallahassee

32960

ACTIVE_NOT_RECRUITING

Florida Cancer Specialists, Vero Beach

33184

ACTIVE_NOT_RECRUITING

Centro di Riferimento Oncologico Di Aviano, Aviano

33401

ACTIVE_NOT_RECRUITING

Florida Cancer Specialists, West Palm Beach

33414

ACTIVE_NOT_RECRUITING

Florida Cancer Specialists, Wellington

33612

RECRUITING

Moffitt Cancer Center McKinley Hospital, Tampa

RECRUITING

Moffitt Cancer Center, Tampa

33905

RECRUITING

Florida Cancer Specialists, Fort Myers

33908

RECRUITING

Florida Cancer Specialists, Fort Myers

33909

RECRUITING

Florida Cancer Specialists, Cape Coral

33980

RECRUITING

Florida Cancer Specialists, Port Charlotte

34102

RECRUITING

Florida Cancer Specialists, Naples

34135

RECRUITING

Florida Cancer Specialists, Bonita Springs

34205

RECRUITING

Florida Cancer Specialists, Bradenton

34211

RECRUITING

Florida Cancer Specialists, Bradenton

34232

RECRUITING

Florida Cancer Specialists, Sarasota

34236

RECRUITING

Florida Cancer Specialists, Sarasota

34285

RECRUITING

Florida Cancer Specialists, Venice

34292

RECRUITING

Florida Cancer Specialists, Venice

34722

NOT_YET_RECRUITING

T.C. Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi, Istanbul

34994

ACTIVE_NOT_RECRUITING

Florida Cancer Specialists, Stuart

35128

ACTIVE_NOT_RECRUITING

IOV-Istituto Oncologico Veneto IRCCS-U.O. Oncologia Medica 1-SC Farmacia, Padua

37920

RECRUITING

University of Tennessee Medical Center, Knoxville

41013

ACTIVE_NOT_RECRUITING

Hospital Universitario Virgen del Rocío, Seville

43210

NOT_YET_RECRUITING

James Cancer Hospital & Solove Research Institute, Columbus

NOT_YET_RECRUITING

Ohio State University Hospital, Columbus

NOT_YET_RECRUITING

Ohio State University, Columbus

NOT_YET_RECRUITING

OSU Wexner Medical Center & James Cancer Hospital, Columbus

44106

RECRUITING

University Hospitals Cleveland Medical Center, Cleveland

48201

RECRUITING

Karmanos Cancer Institute, Detroit

48202

RECRUITING

Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion), Detroit

48334

RECRUITING

Karmanos Cancer Institute Weisberg Cancer Treatment Center, Farmington Hills

48910

RECRUITING

Karmanos Cancer Institute at McLaren Greater Lansing, Lansing

49424

RECRUITING

Cancer & Hematology Centers of Western Michigan, PC, Holland

49444

RECRUITING

Cancer & Hematology Centers of Western Michigan, PC, Norton Shores

49503

RECRUITING

Cancer & Hematology Centers of Western Michigan, PC, Grand Rapids

49546

RECRUITING

Cancer & Hematology Centers of Western Michigan, PC- Kit Storage, Grand Rapids

52621

ACTIVE_NOT_RECRUITING

Sheba Medical Center, Ramat Gan

53226

RECRUITING

Froedtert Hospital/Medical College of Wisconsin, Milwaukee

56126

ACTIVE_NOT_RECRUITING

Azienda Ospedaliero Universitaria Pisana, Pisa

60015

RECRUITING

Accellacare - Deerfield, Deerfield

60422

RECRUITING

UChicago Medicine at Ingalls - Flossmoor, Flossmoor

60426

RECRUITING

UChicago Medicine Ingalls Memorial, Harvey

60451

RECRUITING

University of Chicago Comprehensive Cancer Center at Silver Cross Hospital, New Lenox

60462

RECRUITING

The University of Chicago Medicine Center for Advanced Care Orland Park, Orland Park

60477

RECRUITING

UChicago Medicine at Ingalls - Tinley Park, Tinley Park

60611

RECRUITING

UChicago Medicine - River East, Chicago

60637

RECRUITING

University of Chicago Medical Center, Chicago

73104

RECRUITING

OU Health Stephenson Cancer Center, Oklahoma City

RECRUITING

OU Medical Center, Oklahoma City

75204

NOT_YET_RECRUITING

Baylor Scott and White Research Institute, Dallas

76508

NOT_YET_RECRUITING

Baylor Scott & White Medical Center - Temple, Temple

77030

RECRUITING

The University of Texas MD Anderson Cancer Center, Houston

84112

NOT_YET_RECRUITING

Huntsman Cancer Institute at The University of Utah, Salt Lake City

85234

RECRUITING

Banner Gateway Medical Center, Gilbert

RECRUITING

Banner MD Anderson Cancer Center, Gilbert

90027

RECRUITING

Kaiser Permanente Los Angeles Medical Offices, Los Angeles

90034

RECRUITING

Kaiser Permanente West Los Angeles Medical Center, Los Angeles

90067

NOT_YET_RECRUITING

Valkyrie Clinical Trials, Los Angeles

90095

RECRUITING

Ronald Reagan UCLA Medical Center, Drug Information Center, Los Angeles

RECRUITING

UCLA Hematology Oncology, Los Angeles

90404

RECRUITING

UCLA Hematology/Oncology - Santa Monica, Santa Monica

90706

RECRUITING

Kaiser Permanente Bellflower Medical Offices, Bellflower

90710

RECRUITING

Kaiser Permanente South Bay Medical center, Harbor City

91010

ACTIVE_NOT_RECRUITING

City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte

91367

RECRUITING

Kaiser Permanente Woodland Hills Medical Center, Woodland Hills

91402

RECRUITING

Kaiser Permanente Panorama City Medical Center, Medical Offices 3, Panorama City

91706

RECRUITING

Kaiser Permanente Baldwin Park Medical Center, Baldwin Park

91761

RECRUITING

Kaiser Permanente Ontario Medical Center, Ontario

92078

RECRUITING

Kaiser Permanente San Marcos Medical Offices, San Marcos

92108

RECRUITING

Kaiser Permanente San Diego Mission Road (Regulatory and Lab Supplies), San Diego

92120

RECRUITING

Kaiser Permanente Zion Medical Center, San Diego

92335

RECRUITING

Kaiser Permanente Fontana Medical Center, Fontana

92505

RECRUITING

Kaiser Permanente Riverside Medical Center, Riverside

RECRUITING

Southern California Permanente Medical Group (SCPMG), Riverside

92612

RECRUITING

Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92618

RECRUITING

Kaiser Permanente Alton/Sand Canyon Medical Offices, Irvine

92806

RECRUITING

Kaiser Permanente Anaheim Kraemer Medical Offices, Anaheim

92868

RECRUITING

UC Irvine Health, Orange

94115

RECRUITING

UCSF Cancer Center MZ Phlebotomy, San Francisco

RECRUITING

UCSF Mount Zion Phlebotomy, San Francisco

94143

RECRUITING

UCSF Parnassus Phlebotomy, San Francisco

94158

RECRUITING

UCSF Investigational Drugs Pharmacy, San Francisco

RECRUITING

University of California, San Francisco, San Francisco

98104

RECRUITING

Harborview Medical Center, Seattle

98109

RECRUITING

Fred Hutchinson Cancer Center, Seattle

98195

RECRUITING

University of Washington Medical Center, Seattle

3109601

ACTIVE_NOT_RECRUITING

Rambam Health Care Campus, Haifa

4941492

ACTIVE_NOT_RECRUITING

Rabin medical Center, Petah Tikva

5265601

ACTIVE_NOT_RECRUITING

The Chaim Sheba Medical Center, Ramat Gan

6423906

ACTIVE_NOT_RECRUITING

Tel Aviv Sourasky Medical Center, Tel Aviv

7510032

RECRUITING

Oncovida SA, Santiago

8330032

RECRUITING

Pontificia Universidad Catolica de Chile, Santiago

California

RECRUITING

"University of California, San Francisco , HDFCCC - Hematopoietic Malignancies"

01655

RECRUITING

UMass Memorial Medical Center, Worcester

RECRUITING

University of Massachusetts Chan Medical School, Worcester

07920

RECRUITING

MSK Basking Ridge, Basking Ridge

07748

RECRUITING

MSK Monmouth, Middletown

07645

RECRUITING

MSK Bergen, Montvale

R8500ACE

RECRUITING

Clinica Viedma, Viedma

C1118AAT

RECRUITING

Hospital Aleman, Buenos Aires

C1125

RECRUITING

Fundacion CENIT para la lnvestigacion en Neurociencias, Buenos Aires

C1426ANZ

RECRUITING

Instituto Medico Especializado Alexander Fleming, Buenos Aires

ZC 1419

RECRUITING

Hospital Sirio Libanes - Buenos Aires, Buenos Aires

C1019ABS

RECRUITING

Centro Medico Austral, CABA

ZC 1426

RECRUITING

Centro Oncologico Korben, Caba

X5000

RECRUITING

Instituto Oncologico de Cordoba, Córdoba

QLD 4101

RECRUITING

Mater Cancer Care Centre, Mater Misericordiae Limited, South Brisbane

T3N 4N1

RECRUITING

Arthur J.E. Child Comprehensive Cancer Centre, Calgary

V5Z 1H7

RECRUITING

BC Cancer - Vancouver Fairmont Medical Building, Vancouver

V5Z 4E6

RECRUITING

BC Cancer - Vancouver, Vancouver

R3E 0V9

RECRUITING

CancerCare Manitoba, Winnipeg

H3T 1E2

RECRUITING

Jewish General Hospital, Montreal

Unknown

RECRUITING

Centre Hospitalier Universitaire de Sherbrooke, Fleurimont

CP 1720430

RECRUITING

IC La Serena Research SpA, La Serena

00168

ACTIVE_NOT_RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma

ACTIVE_NOT_RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma

05100

ACTIVE_NOT_RECRUITING

Azienda Ospedaliera S. Maria di Terni, Terni

ACTIVE_NOT_RECRUITING

S.C. Farmacia Interna, Terni

277-8577

ACTIVE_NOT_RECRUITING

National Cancer Center Hospital East, Kashiwa-shi

060-8543

ACTIVE_NOT_RECRUITING

Sapporo Medical University Hospital, Sapporo

565-0871

ACTIVE_NOT_RECRUITING

Osaka University Hospital, Suita-shi

770-8503

ACTIVE_NOT_RECRUITING

Tokushima University Hospital, Tokushima

135-8550

ACTIVE_NOT_RECRUITING

The Cancer Institute Hospital of JFCR, Koto-ku

541-8567

ACTIVE_NOT_RECRUITING

Osaka Prefectural Hospital Organization - Osaka International Cancer Institute, Osaka

08208

ACTIVE_NOT_RECRUITING

Hospital Universitari Parc Tauli Sabadell, Sabadell

08035

ACTIVE_NOT_RECRUITING

Hospital Universitari Vall d'Hebrón, Barcelona

G12 0YN

RECRUITING

Beatson West of Scotland Cancer Centre, Glasgow

CB2 0QQ

RECRUITING

Cambridge University Hospitals NHS Foundation Trust, Cambridge

EC1A 7BE

RECRUITING

Barts Health NHS Trust, St Bartholomew's Hospital, London

SE1 9RT

RECRUITING

Guy's Hospital, London

W6 8RF

RECRUITING

Charing Cross Hospital, London

M20 4BX

NOT_YET_RECRUITING

The Christie NHS Foundation Trust - Christie Hospital, Manchester

NOT_YET_RECRUITING

The Christie NHS Foundation Trust, Manchester

CH63 4JY

RECRUITING

The Clatterbridge Cancer Centre NHS Foundation Trust, The Clatterbridge Cancer Centre - Wirral, Merseyside

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Seagen, a wholly owned subsidiary of Pfizer

INDUSTRY

NCT04879329 - A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2 | Biotech Hunter | Biotech Hunter