452
Participants
Start Date
May 30, 2022
Primary Completion Date
May 16, 2028
Study Completion Date
May 16, 2028
Benzylpenicillin - single dose
"Participants will receive a single dose of IV antibiotic (benzylpenicillin).~Benzylpenicillin dosing: 1 month - 18 years, IV or Intramuscular (IM) 30 mg/kg (maximum 1.2 g) every 6 hours."
Benzylpenicillin - three days
"Participants will receive three days of this IV antibiotic (benzylpenicillin).~Benzylpenicillin dosing: 1 month - 18 years, IV or Intramuscular (IM) 30 mg/kg (maximum 1.2 g) every 6 hours. For severe infections, use up to 60 mg/kg (maximum 2.4 g) every 4-6 hours."
Gentamicin - single dose
"Participants will receive a single dose of IV antibiotic (gentamicin).~Gentamicin dosing: Children ≤10 years old: 7.5 mg/kg (maximum dose 320 mg) Children \>10 years old: 6-7 mg/kg (maximum dose 560 mg)"
Gentamicin - three days
"Participants will receive three days of this IV antibiotic (gentamicin).~Gentamicin dosing: Children ≤10 years old: 7.5 mg/kg (maximum dose 320 mg) Children \>10 years old: 6-7 mg/kg (maximum dose 560 mg)"
Cefalexin - post single dose of IV antibiotics for the remaining two days
Oral antibiotic will be as per local guidelines. i.e. Cefalexin 25mg/kg (maximum dosage 500mg) 4 times a day or 33mg/kg (maximum dosage 500mg) 3 times a day
RECRUITING
Starship Children's Hospital, Auckland
RECRUITING
Royal Children's Hospital, Parkville
RECRUITING
Monash Health, Melbourne
RECRUITING
Perth Children's Hospital, Perth
RECRUITING
Women and Children's Hospital, Adelaide
Lead Sponsor
Royal Children's Hospital
OTHER
Murdoch Childrens Research Institute
OTHER