1,188
Participants
Start Date
May 4, 2021
Primary Completion Date
August 31, 2028
Study Completion Date
October 2, 2034
Atezolizumab
Atezolizumab will be administered at a dose of 1200 mg every three weeks (Q3W) for 14 cycles.
Trastuzumab Emtansine
Trastuzumab emtansine will be administered at a dose of 3.6 mg/kg Q3W for 14 weeks.
Placebo
Placebo matched to atezolizumab will be administered at a dose of 1200 mg Q3W for 14 cycles.
Trastuzumab
Trastuzumab will be used to complete 14 cycles of study treatment if trastuzumab emtansine is discontinued for toxicity not considered to be related to the trastuzumab component of the drug.
National Taiwan University Hospital, Taipei
Mackay Memorial Hospital, Taipei
China Medical University Hospital, Taichung
Chia-Yi Christian Hospital, Chiayi City
National Cheng Kung Uni Hospital, Tainan City
Queen Mary Hospital, Hong Kong
Auckland City Hospital, Cancer and Blood Research, Auckland
Budapesti Szent Margit Korhaz, Budapest
Orszagos Onkologiai Intezet, Budapest
Cliniques Universitaires St-Luc, Brussels
"Medical Center Nadezhda Clinical EOOD", Sofia
University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD, Sofia
Royal North Shore Hospital, St Leonards
Macarthur Cancer Therapy Centre, Campbelltown
Jessa Zkh (Campus Virga Jesse), Hasselt
COC Plovdiv, Plovdiv
Ordensklinikum Linz Barmherzige Schwestern, Linz
Debreceni Egyetem Klinikai Kozpont, Debrecen
Princess Alexandra Hospital, Woolloongabba
Clinique St. Elizabeth, Namur
Lkh Salzburg - Univ. Klinikum Salzburg, Salzburg
Tiroler Landeskrankenanstalten Ges.M.B.H., Innsbruck
Vejle Sygehus, Vejle
Chulalongkorn Hospital, Bangkok
Ramathibodi Hospital, Bangkok
National Cancer Center, Goyang-si
Onkologische Schwerpunktpraxis Kurfürstendamm, Berlin
Hospital de Jerez de la Frontera, Jerez de la Frontera
Seoul National University Bundang Hospital, Seongnam-si
Instituto Nacional De Cancerologia, Distrito Federal
Centre Francois Baclesse, Caen
Klinikum Ernst von Bergmann, Potsdam
Hospital Universitario Clínico San Cecilio, Granada
Abramson Cancer Center; Univ of Pennsylvania; Clinical Research Unit, Philadelphia
Ospedale San Raffaele, Milan
Irccs Istituto Nazionale Dei Tumori (Int), Milan
Hospital Juan Ramon Jimenez, Huelva
Dicle University Faculty of Medicine, Diyarbakır
Städtische Klinik Lüneburg, Lüneburg
Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi, Edirne
Hematology Oncology Associates of Fredericksburg, Inc., Fredericksburg
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico, Jaén
Investigacion Oncofarmaceutica, La Paz
Virginia Cancer Institute, Richmond
Virginia Oncology Associates - Virginia Beach, Virginia Beach
Virginia Oncology Associates, Norfolk
Virginia Oncology Associates - New Port News, Newport News
UNI-Klinikum Campus Kiel Klinik für Gynäkologie und Geburtshilfe, Kiel
Municipal Institution Kirovograd Regional Oncology Dispensary, Kirovograd
CHRU Besançon, Besançon
Asst Degli Spedali Civili Di Brescia, Brescia
Gemeinschaftspraxis für Hämatologie und Onkologie Dr. Reichert/Dr.Janssen, Westerstede
Hospital General Universitario Gregorio Marañon, Madrid
Hospital Clinico San Carlos, Madrid
Levine Cancer Institute, Charlotte
Hospital Quiron de Madrid, Madrid
Hospital Clinico Universitario Virgen de la Victoria, Málaga
CHU Brest Hopital La Cavale Blanche, Brest
Centre Hospitalier Uni Ire Caremeau, Nîmes
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital, Carrollton
Diakovere Henriettenstift, Frauenklinik, Hanover
Irccs Centro Di Riferimento Oncologico (CRO), Aviano
Polyclinique Bordeaux Nord Aquitaine, Bordeaux
Florida Cancer Specialists, West Palm Beach
Istanbul Faculty of Medicine, Istanbul
Istanbul University Cerrahpasa Faculty of Medicine, Istanbul
Ac?badem Altunizade Hastanesi, Üsküdar
Medeniyet University Goztepe Training and Research Hospital., Istanbul
Ege University Medical Faculty, Bornova, ?zm?r
Alabama Oncology, Birmingham
Katip Celebi University Ataturk Training and Research Hospital, Izmir
Hospital Alvaro Cunqueiro, Vigo
Hospital Clinico Universitario de Salamanca, Salamanca
The West Clinic, Germantown
Hospital Universitario de Canarias, San Cristóbal de La Laguna
Srinagarind Hospital, Khon Kaen
Municipal non profit enterprise of Sumy Regional Council Sumy Regional Clinical Oncology Disp, Sumy
Gynonco Düsseldorf, MVZ Medical Center GmbH, Düsseldorf
Hospital Universitario Virgen Macarena, Seville
Hospital Universitario Virgen del Rocio, Seville
A.O. Universitaria Policlinico Di Modena, Modena
Kyungpook National University Medical Center, Daegu
Inonu University Medical Faculty of Medicine, Malatya
Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH, Essen
Hospital Clínico Universitario de Valencia, Valencia
Marienhospital Bottrop, Bottrop
Hospital de Basurto, Bilbao
CI Dnipropetrovsk CMCH #4 of Dnipropetrovsk RC SI Dnipropetrovsk MA of MOHU Ch of Oncology and MR, Dnipropetrovsk
Hospital Universitario Miguel Servet, Zaragoza
Gynäkologisches Zentrum Bonn, Bonn
Azlenda Ospendaliero-Universitaria Pisana, Pisa
Ospedale Civile - Livorno, Livorno
Groupe Hospitalier Public Du Sud De L'Oise GHPSO, Creil
AGAPLESION Markus-Krankenhaus, Frankfurt
Klinik Johann Wolfgang von Goethe Uni, Frankfurt
Municipal Noncommercial Institution Regional Center of Oncology, Kharkiv
Hochwaldkrankenhaus, Bad Nauheim
Filios Alta Medicina, Monterrey
Centro de Investigacion Clinica de Oaxaca, Oaxaca City
CLCC Leon Berard Lyon, Lyon
Groupe Hospitalier Diaconesses, Paris
Institut Curie, Paris
Mays Cancer Center at UT Health San Antonio MD Anderson Cancer, San Antonio
Praxis für Interdisziplinäre Onkologie und Hämatologie GbR, Freiburg im Breisgau
U.O.C. Oncologia Medica Senologica, Napoli
Università degli Studi Federico II, Napoli
Klinik & Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Innenstadt, München
AORN'S.G.Moscati, Avellino
Institut Sainte Catherine, Avignon
Pole Regional De Cancerologie, Poitiers
Klinikum Augsburg, Augsburg
Uzhgorod Central City Clinical Hospital, Uzhhorod
Songklanagarind Hospital, Songkhla
UCLA Medical Center, Santa Monica
Innovation Clinical Research Institute, Whittier
Roy and Patricia Disney Family Cancer Center- Providence Saint Joseph Medical Center, Buena
HOPITAL RENE HUGUENIN, Institut Curie, Saint-Cloud
Leopoldina Krankenhaus der Stadt Schweinfurt GmbH, Schweinfurt
Providence Regional Cancer Partnership, Everett
Northwest Medical Specialties, Tacoma
Frauenarztpraxis Dr. Apel, Dr. Kolpin, Erfurt
Rajiv Gandhi Cancer Institute & Research Center, New Delhi
Max Super Speciality Hospital, North WEST Delhi
"SBIH Moscow Clinical Scientific and Practical Center named after A.S. Loginov of DHM", Moskva
FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF, Moscow
MEDSI Clinical Hospital on Pyatnitsky Highway, Moscow
Regional Clinical Oncology Hospital, Yaroslavl
Harbin Medical University Cancer Hospital, Harbin
National Cancer Centre, Singapore
SBI of Healthcare Leningrad Regional Oncology Dispensary, Saint Peterburg
"Medical Clinic AB Medical group", Saint Petersburg
FSBI?National Medical Research Center of Oncology named after N.N.Petrov? MHRF, Saint Petersburg
S-Pb clinical scientific practical center of specialized kinds of medical care (oncological), Saint Petersburg
Zhongshan Hospital Fudan University, Shanghai
Centrul de Oncologie Sfantul Nectarie, Craiova
SBIH Kaluga Region Clinical Oncology Dispensary, Kaluga
Oncomed SRL, Timișoara
Zhejiang Cancer Hospital, Zhejiang
Hemato Oncology Clinic Ahmedabad Pvt Ltd, Ahmedabad
Cluj-Napoca Emergency Clinical County Hospital, Cluj-Napoca
Tata Memorial Hospital, Mumbai
Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj-Napoca, Cluj-Napoca
Chongqing Cancer Hospital, Chongqing
Amethyst Cluj, Cluj County
Sahyadri Super Specialty Hospital Hadapsar, Pune
Republican Clinical Oncological Dispensary of the Ministry of Healthcare, Kazan
HCG Manavata Cancer Centre, Nashik
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan
Henan Cancer Hospital, Zhengzhou
Sun Yat-sen Memorial Hospital, Guangzhou
Guangdong Provincial People's Hospital, Guangzhou
Manipal Hospital, Bangalore
Nizhny Novgorod Regional Clinical Oncology Center, Nizhny Novgorod
Sichuan Cancer Hospital, Chengdu
West China Hospital - Sichuan University, Chengdu
"LLC Medical and Sanitary Unit Clinician", Novosibirsk
Christian Med Clg & Hspt, Ratnagiri Kilminnal
Regional Oncology Dispensary, Tomsk
TATA Medical Centre, Kolkata
First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an
University of Iowa, Iowa City
New England Cancer Specialists, Westbrook
The Valley Hospital, Paramus
Thompson Cancer Survival Center, Knoxville
Kadlec Clinic Hematology and Oncology, Kennewick
Crio - Centro Regional Integrado de Oncologia, Fortaleza
Hospital Sao Rafael - HSR, Salvador
Hospital Araujo Jorge, Goiânia
Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijuí
Santa Casa de Misericordia de Porto Alegre, Porto Alegre
Hospital Sao Lucas - PUCRS, Porto Alegre
Hospital Nossa Senhora da Conceicao, Porto Alegre
Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto
Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda, São Paulo
Núcleo de Pesquisa São Camilo, São Paulo
The First Affilicated Hospital, Sun Yat-sen University, Guangzhou
Tianjin Medical University Cancer Institute & Hospital, Tianjin
Pamela Youde Nethersole Eastern Hospital, Hong Kong
Tuen Mun Hospital, Hong Kong
Masaryk?v onkologický ústav, Brno
Fakultni Nemocnice Hradec Kralove, Hradec Králové
Nemocnice AGEL Novy Jicin a.s., Nový Jičín
Fakultni nemocnice Olomouc, Olomouc
Fakultni Poliklinika Vseobecne Fakultni Niemocnice, Prague
Fakultni Thomayerova nemocnice, Praha 4 - Krc
Städtisches Klinikum Dessau, Dessau
Anticancer Hospital Ag. Savas, Athens
Alexandras General Hospital of Athens, Athens
University General Hospital of Heraklion, Crete
University Hospital of Larissa, Larissa
Metropolitan Hospital, Piraeus
European Interbalkan Medical Center, Thessaloniki
Policlinico Universitario Agostino Gemelli, Rome
Aga Khan University Hospital, Nairobi
Health Pharma Professional Research, Mexico City
Centro Medico Dalinde, Mexico City
Bialostockie Centrum Onkologii, Bialystok
Uniwersyteckie Centrum Kliniczne, Gda?sk
Narodowy Instytut Onkologii Odzia? w Gliwicach, Gliwice
Szpital Uniwersytecki w Krakowie, Oddzia? Kliniczny Kliniki Onkologii, Krakow
Wielkopolskie Centrum Onkologii, Poznan
Centrum Onkologii Instytut im.M. Sklodowskiej-Curie, Warsaw
Hospital CUF Tejo, Lisbon
Hospital de Santa Maria, Lisbon
Hospital Beatriz Angelo, Loures
IPO do Porto, Porto
Filantropia Clinical Hospital, Bucharest
Samsung Medical Center, Seoul
Seoul National University Hospital, Seoul
Severance Hospital, Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Gangnam Severance Hospital, Seoul
Seoul St Mary's Hospital, Seoul
Korea University Guro Hospital, Seoul
Hospital General Universitario de Elche, Elche
Hospital Universitari Germans Trias i Pujol, Badalona
Corporacio Sanitaria Parc Tauli, Sabadell
Taipei Veterans General Hospital, Taipei
Adana Baskent University Hospital, Adana
Hacettepe University Medical Faculty, Ankara
Ankara Bilkent City Hospital, Ankara
Gazi University Medical Faculty, Oncology Hospital, Ankara
Memorial Ankara Hastanesi, Ankara
Antalya Training and Research Hospital, Antalya
Medical Park Seyhan Hospital, Seyhan
Uganda Cancer Institute, Kampala
Kyiv City Clinical Oncological Center, Kyiv
Blackpool Victoria Hospital, Blackpool
Royal Sussex County Hospital, Brighton
Addenbrookes Hospital, Cambridge
Cheltenham General Hospital, Cheltenham
Barts & London School of Med, London
University College London Hospital, London
Royal Free Hospital, London
Royal Marsden Hospital - London, London
Christie Hospital NHS Trust, Manchester
Mount Vernon Cancer Centre, Northwood
Royal Preston Hospital, Preston
Royal Cornwall Hospital, Truro
Hoffmann-La Roche
INDUSTRY