NCT04870944 - CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

January 28, 2022

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions

Diffuse Midline Glioma, H3 K27-AlteredMetastatic Malignant Neoplasm in the Central Nervous SystemRecurrent Diffuse Intrinsic Pontine GliomaRecurrent Diffuse Midline Glioma, H3 K27-AlteredRecurrent LymphomaRecurrent Malignant Solid NeoplasmRecurrent Primary Malignant Central Nervous System NeoplasmRefractory LymphomaRefractory Malignant Solid NeoplasmRefractory Primary Malignant Central Nervous System Neoplasm

Interventions

PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

PROCEDURE

Bone Marrow Aspirate

Undergo bone marrow aspirate

PROCEDURE

Bone Marrow Biopsy

Undergo bone marrow biopsy

PROCEDURE

Echocardiography Test

Undergo ECHO

DRUG

FACT Complex-targeting Curaxin CBL0137

Given IV

Trial Locations (34)

2031

SUSPENDED

Sydney Children's Hospital, Randwick

10032

RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10595

RECRUITING

New York Medical College, Valhalla

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

15224

RECRUITING

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

20010

RECRUITING

Children's National Medical Center, Washington D.C.

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

27710

SUSPENDED

Duke University Medical Center, Durham

30329

RECRUITING

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta

33701

RECRUITING

Johns Hopkins All Children's Hospital, St. Petersburg

35233

RECRUITING

Children's Hospital of Alabama, Birmingham

38105

RECRUITING

Saint Jude Children's Research Hospital, Memphis

45229

RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

46202

RECRUITING

Riley Hospital for Children, Indianapolis

48109

RECRUITING

C S Mott Children's Hospital, Ann Arbor

55455

RECRUITING

University of Minnesota/Masonic Cancer Center, Minneapolis

60611

RECRUITING

Lurie Children's Hospital-Chicago, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

63110

RECRUITING

Washington University School of Medicine, St Louis

64108

RECRUITING

Children's Mercy Hospitals and Clinics, Kansas City

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

RECRUITING

Cook Children's Medical Center, Fort Worth

77030

RECRUITING

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

80045

RECRUITING

Children's Hospital Colorado, Aurora

84113

RECRUITING

Primary Children's Hospital, Salt Lake City

85016

RECRUITING

Phoenix Childrens Hospital, Phoenix

90027

RECRUITING

Children's Hospital Los Angeles, Los Angeles

92868

RECRUITING

Children's Hospital of Orange County, Orange

94158

RECRUITING

UCSF Medical Center-Mission Bay, San Francisco

97239

RECRUITING

Oregon Health and Science University, Portland

98105

RECRUITING

Seattle Children's Hospital, Seattle

02215

RECRUITING

Dana-Farber Cancer Institute, Boston