Effect of Ubiquinol Supplementation on Ovulation Induction in Clomiphene Citrate Resistance

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

161

Participants

Timeline

Start Date

April 1, 2019

Primary Completion Date

July 31, 2020

Study Completion Date

July 31, 2020

Conditions
Polycystic Ovarian Syndrome
Interventions
DRUG

Controlled ovarian stimulation by Combined Clomiphene Citrate and Ubiquinol Versus hMG

In group A, controlled ovarian stimulation (COS) was done by Clomiphene Citrate (Fertab® 50 mg tablets, Zynova. SITCO Pharma.) as 150 mg (3 tablets) daily for 5 days (from 2nd day till 6th day of the cycle) together with Ubiquinol (active form of Coenzyme Q10) starting from 2nd day till the day of human Chorionic Gonadotropin (hCG) triggering in a dose of 100 mg capsules orally once daily, immediately after meal (Nutraquinol®; Jamjoom Pharma Nutraceuticals). In group B, Human Menopausal Gonadotropins (hMG) (Merional® 75 I.U. vials, IBSA.) IM was given from 2nd day of the cycle in a dose ranging from 75 to 225 IU according to the patient's response. Patients were instructed not to take any non-study drugs during the whole study period.

Trial Locations (1)

41311

Saudi German Hospital, Al Madīnah

All Listed Sponsors
lead

Saudi German Hospital - Madinah

OTHER

NCT04870502 - Effect of Ubiquinol Supplementation on Ovulation Induction in Clomiphene Citrate Resistance | Biotech Hunter | Biotech Hunter