Pre-emptive Treatments in Lupus Nephritis Patients With Serological Reactivation

NACompletedINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

April 21, 2016

Primary Completion Date

March 31, 2022

Study Completion Date

March 31, 2022

Conditions
Lupus Nephritis
Interventions
PROCEDURE

Pre-emptive increase of immunosuppressive treatments

"1. Increase prednisolone to 0.4-0.5 mg/kg/day; taper by 5 mg every 2 weeks to reach 15mg/day; then further reduce by 2.5 mg every 2 week and aim to reach 5-7.5 mg/day after 12 weeks.~2. Adjustment of the 2nd agent would be as follows:~ 1. For patients who receive AZA \<75mg/day; increase the dose of AZA to 75 mg/day.~ 2. For patients who receive MMF \<1g/day, increase the dose of MMF to 1g/day."

DRUG

Prednisolone and/or AZA/MMF

Prednisolone and/or AZA/MMF

Trial Locations (2)

Unknown

Queen Mary Hospital, Hong Kong, Hong Kong

United Christian Hospital, Hong Kong

All Listed Sponsors
collaborator

United Christian Hospital

OTHER

lead

The University of Hong Kong

OTHER

NCT04870359 - Pre-emptive Treatments in Lupus Nephritis Patients With Serological Reactivation | Biotech Hunter | Biotech Hunter