Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

576

Participants

Timeline

Start Date

April 28, 2021

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2027

Conditions
Non-Small Cell Lung Cancer MetastaticGastric CancerEsophageal Squamous Cell CarcinomaHead and Neck Squamous Cell CarcinomaColorectal Cancer
Interventions
DRUG

MCLA-129

full length IgG1 bispecific antibody that specifically targets the receptor tyrosine kinases EGFR and c-MET

DRUG

Osimertinib

Approved, 3rd-generation EGFR-TKI

DRUG

Chemotherapy

administrated by IV infusion

Trial Locations (51)

2650

COMPLETED

Antwerp University Hospital, Edegem

6351

COMPLETED

Samsung Medical Center, Seoul

8023

COMPLETED

IOB Institute of Oncology - Hospital Quironsalud Barcelona, Barcelona

10043

COMPLETED

Azienda Ospedaliero - Universitaria San Luigi Gonzaga, Orbassano

13009

RECRUITING

L'Institut Paoli - Calmettes, Marseille

16247

RECRUITING

The Catholic University of Korea, St. Vincent's Hospital, Suwon, Gyeonggi-do

20133

COMPLETED

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

21565

COMPLETED

Gachon University Gil Hospital, Incheon

22031

RECRUITING

Next Oncology Virginia, Fairfax

22162

RECRUITING

ASST Grande Ospedale Metropolitano Niguarda, Milan

25123

RECRUITING

ASST degli Spedali Civili di Brescia, Brescia

28007

COMPLETED

Hospital General Universitario Gregorio Marañón, Madrid

28027

RECRUITING

Clínica Universidad de Navarra -Madrid, Madrid

28040

RECRUITING

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28041

RECRUITING

Hospital Universitario 12 de Octubre, Madrid

28050

RECRUITING

Centro Integral Oncológico Clara Campal, Madrid

28223

RECRUITING

Hospital Quirón Madrid, Madrid

31008

RECRUITING

Clínica Universidad de Navarra, Pamplona

33000

RECRUITING

CHU Hopitaux de Bordeaux - Hôpital Saint-André, Bordeaux

37126

COMPLETED

Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento, Verona

37203

COMPLETED

Sarah Cannon Research Institute, Nashville

40138

COMPLETED

Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi, Bologna

44093

RECRUITING

CHU de Nantes - Hôpital Nord Laennec, Nantes

46009

COMPLETED

Fundación Instituto Valenciano de Oncología (IVO), Valencia

46026

RECRUITING

Hospital Universitari i Politècnic La Fe, Valencia

59037

RECRUITING

Hôpital Albert Calmette, Lille

60488

COMPLETED

Krankenhaus Nordwest, Frankfurt am Main

63069

COMPLETED

Sana Klinikum Offenbach GmbH, Offenbach

69677

RECRUITING

CHU de Lyon - Louis Pradel Hospital, Bron

75014

RECRUITING

Marie Wislez, Paris

75877

RECRUITING

Hôpital Bichat - Claude-Bernard, Paris

75908

COMPLETED

Hôpital Européen Georges Pompidou (HEGP), Paris

80090

COMPLETED

Clinique de l'Europe, Amiens

84119

COMPLETED

START Mountain Region, West Valley City

84131

RECRUITING

Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi d'Aragona, Salerno

86000

RECRUITING

CHU de Poitiers, Poitiers

92868

RECRUITING

University of California, Irvine, Orange

94010

RECRUITING

Centre Hospitalier Intercommunal de Créteil, Créteil

94163

RECRUITING

Hôpital d'Instruction des Armées Bégin, Saint-Mandé

169610

COMPLETED

National Cancer Centre of Singapore, Singapore

Unknown

RECRUITING

Institut Jules Bordet, Anderlecht

RECRUITING

Netherlands Cancer Institute, Amsterdam

COMPLETED

University Medical Center Groningen, Groningen

RECRUITING

Erasmus Medical Center, Rotterdam

COMPLETED

Seoul National University Hospital, Seoul

RECRUITING

Severance Hospital - Yonsei Cancer Center, Seoul

COMPLETED

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

00144

RECRUITING

Istituto Nazionale dei Tumori Regina Elena, Roma

08023

RECRUITING

Hospital HM Delfos, Barcelona

08025

RECRUITING

Hospital de la Santa Creu i Sant Pau, Barcelona

08035

RECRUITING

Hospital Universitario Vall d'Hebron, Barcelona

All Listed Sponsors
lead

Merus N.V.

INDUSTRY