4,034
Participants
Start Date
April 26, 2021
Primary Completion Date
July 19, 2021
Study Completion Date
March 13, 2023
VLA2001
whole virus inactivated SARS-CoV-2 vaccine adjuvanted with cytosine phospho-guanine (CpG) 1018 in combination with aluminium hydroxide 2 vaccinations 28 days apart
AZD1222
2 vaccinations 28 days apart AZD1222 is a recombinant, replication-defective chimpanzee adenovirus expressing the SARS-CoV-2 S surface glycoprotein.
VLA2001 - adolescent part
whole virus inactivated SARS-CoV-2 vaccine adjuvanted with cytosine phospho-guanine (CpG) 1018 in combination with aluminium hydroxid 2 vaccinations 28 days apart and with a booster vaccination on day 208. Placebo group will receive VLA2001 on day 208 and following second vaccination 28 days later.
Placebo
2 vaccinations 28 days apart with placebo (PBS buffer based on Dulbecco's PBS media formulation without Calcium and Magnesium )
Barnsley Hospital NHS FT, Barnsley
University Hospitals Birmingham NHS Foundation Trust, Birmingham
Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool
North Bristol NHS Trust, Bristol
University Hospitals Bristol and Weston NHS Foundation Trust, Bristol
Cambridge Biomedical Research Centre, Cambridge
Cheadle Community Hospital, Cheadle
University Hospitals Coventry & Warwickshire, Coventry
Western General Hospital, Edinburgh - NHS Lothian, Edinburgh
Epsom and St. Helier University Hospitals NHS Trust, Epsom
Queen Elizabeth University Hospital-Glasgow- NHS Greater Glasgow, Glasgow
Royal Surrey County Hospital NHS Foundation Trust, Guildford
University Hospitals of Leicester NHS Trust, Leicester
NHS Foundation Trust Royal Liverpool University Hospital, Liverpool
Barts Health NHS Trust, London
Panthera London, London
Royal Free London NHS Foundation Trust, London
King's College Hospital, Trust College HOspital NHS Foundation Trust, London
Chelsea and Westminster Hospital NHS Trust, London
St George's University Hospitals NHS Foundation Trust, London
NIHR UCLH Clinical Research Facility, London
The Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital Newcastle, Newcastle
Northumbria Healthcare NHS Foundation Trust - North Tyneside General Hospital, North Shields
Lakeside Healthcare Research, Northampton
Nottingham University Hospitals NHS Trust, Nottingham
University Hospital Plymouth NHS Trust, Plymouth
Panthera Biopartners Preston, Preston
Panthera Biopartners Manchester, Rochdale
Northern Care Alliance NHS Group, Salford Royal NHS Foundation Trust, Salford
Southampton University Hospitals NHS Trust, Southampton
Royal Cornwall Hospitals NHS Trust, Truro
Valneva Austria GmbH
INDUSTRY