895
Participants
Start Date
May 10, 2021
Primary Completion Date
November 1, 2027
Study Completion Date
August 14, 2029
Capivasertib
Phase Ib: Capivasertib 320 mg/ 400 mg administered PO BD 4 days on /3 days off per week for 4 weeks (28 days cycle) Phase III: : Capivasertib, administered PO BD 4 days on / 3 days off per week for 4 weeks (28 days cycle) at the dose confirmed in the phase Ib portion
Fulvestrant
Phase Ib and Phase III: 500 mg (2 injections of 250 mg) on Day 1 of Weeks 1 and 3 of Cycle 1, and then on Day 1, Week 1 of each cycle thereafter
Palbociclib
Phase Ib: 100 mg/ 125 mg. Once daily for 21 consecutive days followed by 7 days off treatment to comprise a complete 28-day cycle Phase III: Administered once daily for 21 days of 28-day cycle, at the dose of 125 mg.
Ribociclib
Phase Ib: 200 mg/ 400 mg/ 600 mg. Once daily for 21 consecutive days followed by 7 days off treatment to comprise a complete 28-day cycle Phase III: Administered once daily for 21 days of 28-day cycle, at the dose confirmed in the phase 1b portion.
Abemaciclib
Phase Ib: 50 mg/ 100 mg/ 150 mg. Twice daily for 28 consecutive days to comprise a complete 28-day cycle
RECRUITING
Research Site, Taoyuan District
RECRUITING
Research Site, Tainan City
RECRUITING
Research Site, Brussels
ACTIVE_NOT_RECRUITING
Research Site, CABA
ACTIVE_NOT_RECRUITING
Research Site, CABA
ACTIVE_NOT_RECRUITING
Research Site, Buenos Aires
ACTIVE_NOT_RECRUITING
Research Site, Rosario
RECRUITING
Research Site, Darlinghurst
WITHDRAWN
Research Site, Wahroonga
WITHDRAWN
Research Site, Miranda
RECRUITING
Research Site, Waratah
RECRUITING
Research Site, Edegem
RECRUITING
Research Site, Brasschaat
RECRUITING
Research Site, Leuven
RECRUITING
Research Site, Hillerød
RECRUITING
Research Site, Odense
ACTIVE_NOT_RECRUITING
Research Site, Seoul
ACTIVE_NOT_RECRUITING
Research Site, Nedlands
RECRUITING
Research Site, Nedlands
ACTIVE_NOT_RECRUITING
Research Site, Ankara
RECRUITING
Research Site, Haine-Saint-Paul
RECRUITING
Research Site, Barcelona
RECRUITING
Research Site, Aarhus N
RECRUITING
Research Site, Aalborg
RECRUITING
Research Site, Taipei
RECRUITING
Research Site, New York
RECRUITING
Research Site, New York
ACTIVE_NOT_RECRUITING
Research Site, Bangkok
ACTIVE_NOT_RECRUITING
Research Site, Dusit
ACTIVE_NOT_RECRUITING
Research Site, Bangkok
RECRUITING
Research Site, George Town
WITHDRAWN
Research Site, Bangkok
ACTIVE_NOT_RECRUITING
Research Site, Bangkok
ACTIVE_NOT_RECRUITING
Research Site, Ratchathewi
ACTIVE_NOT_RECRUITING
Research Site, Goyang-si
RECRUITING
Research Site, Taipei
RECRUITING
Research Site, Pulau Pinang
ACTIVE_NOT_RECRUITING
Research Site, Bangkok
RECRUITING
Research Site, Berlin
WITHDRAWN
Research Site, Brooklyn
RECRUITING
Research Site, Mineola
RECRUITING
Research Site, Berlin
RECRUITING
Research Site, Pittsburgh
RECRUITING
Research Site, Santiago de Compostela
RECRUITING
Research Site, Solna
TERMINATED
Research Site, York
RECRUITING
Research Site, Granada
RECRUITING
Research Site, Philadelphia
RECRUITING
Research Site, Newark
WITHDRAWN
Research Site, Rozzano
WITHDRAWN
Research Site, Milan
WITHDRAWN
Research Site, Milan
RECRUITING
Research Site, Leesburg
RECRUITING
Research Site, Hamburg
WITHDRAWN
Research Site, Baltimore
WITHDRAWN
Research Site, Baltimore
RECRUITING
Research Site, Annapolis
WITHDRAWN
Research Site, Stade
RECRUITING
Research Site, Falls Church
RECRUITING
Research Site, Plérin
RECRUITING
Research Site, Midlothian
RECRUITING
Research Site, Norfolk
RECRUITING
Research Site, Kiel
RECRUITING
Research Site, Lleida
WITHDRAWN
Research Site, Durham
RECRUITING
Research Site, Madrid
RECRUITING
Research Site, Madrid
WITHDRAWN
Research Site, Madrid
RECRUITING
Research Site, Málaga
TERMINATED
Research Site, Greenville
RECRUITING
Research Site, Hanover
RECRUITING
Research Site, Hangzhou
RECRUITING
Research Site, Pamplona
WITHDRAWN
Research Site, Aviano
RECRUITING
Research Site, Padua
RECRUITING
Research Site, Vaxjo
ACTIVE_NOT_RECRUITING
Research Site, Karşıyaka
RECRUITING
Research Site, Nashville
RECRUITING
Research Site, Chattanooga
WITHDRAWN
Research Site, Kayseri
ACTIVE_NOT_RECRUITING
Research Site, Khon Kaen
RECRUITING
Research Site, Bologna
WITHDRAWN
Research Site, Louisville
RECRUITING
Research Site, Louisville
RECRUITING
Research Site, Mönchengladbach
ACTIVE_NOT_RECRUITING
Research Site, Malatya
RECRUITING
Research Site, Saint-Herblain
NOT_YET_RECRUITING
Research Site, Essen
RECRUITING
Research Site, Kuala Selangor
RECRUITING
Research Site, Bottrop
WITHDRAWN
Research Site, Fort Wayne
WITHDRAWN
Research Site, Münster
RECRUITING
Research Site, Detroit
RECRUITING
Research Site, Georgsmarienhütte
RECRUITING
Research Site, Grand Rapids
RECRUITING
Research Site, Florence
ACTIVE_NOT_RECRUITING
Research Site, Chiang Mai
RECRUITING
Research Site, Kuala Lumpur
ACTIVE_NOT_RECRUITING
Research Site, Lampang
RECRUITING
Research Site, Trier
ACTIVE_NOT_RECRUITING
Research Site, Samsun
RECRUITING
Research Site, Prato
RECRUITING
Research Site, Kuala Lumpur
RECRUITING
Research Site, Kuala Selangor
RECRUITING
Research Site, Quincy
RECRUITING
Research Site, Clermont-Ferrand
RECRUITING
Research Site, St Louis
RECRUITING
Research Site, Hannibal
RECRUITING
Research Site, Frankfurt am Main
RECRUITING
Research Site, Omaha
RECRUITING
Research Site, Mannheim
RECRUITING
Research Site, Lyon
RECRUITING
Research Site, Ho Chi Minh City
WITHDRAWN
Research Site, Covington
WITHDRAWN
Research Site, Baton Rouge
RECRUITING
Research Site, Heilbronn
RECRUITING
Research Site, Dallas
RECRUITING
Research Site, Rouen
WITHDRAWN
Research Site, Fort Worth
SUSPENDED
Research Site, Houston
RECRUITING
Research Site, San Antonio
RECRUITING
Research Site, San Antonio
RECRUITING
Research Site, Freiburg im Breisgau
RECRUITING
Research Site, Aurora
RECRUITING
Research Site, Napoli
RECRUITING
Research Site, Kaohsiung City
RECRUITING
Research Site, Kaohsiung City
NOT_YET_RECRUITING
Research Site, Salt Lake City
RECRUITING
Research Site, Tucson
RECRUITING
Research Site, Augsburg
RECRUITING
Research Site, Limoges
WITHDRAWN
Research Site, Catanzaro
RECRUITING
Research Site, Ulm
SUSPENDED
Research Site, Los Angeles
WITHDRAWN
Research Site, Los Angeles
ACTIVE_NOT_RECRUITING
Research Site, Hat Yai
RECRUITING
Research Site, Erlangen
RECRUITING
Research Site, Glendale
SUSPENDED
Research Site, Newport Beach
RECRUITING
Research Site, Fountain Valley
RECRUITING
Research Site, Santa Rosa
RECRUITING
Research Site, Bobigny
RECRUITING
Research Site, Regensburg
WITHDRAWN
Research Site, Santa Barbara
RECRUITING
Research Site, Kuching
RECRUITING
Research Site, San Francisco
RECRUITING
Research Site, Napa
RECRUITING
Research Site, Villejuif
RECRUITING
Research Site, Misterbianco
RECRUITING
Research Site, Gresham
RECRUITING
Research Site, Tacoma
RECRUITING
Research Site, Hanoi
ACTIVE_NOT_RECRUITING
Research Site, Beijing
ACTIVE_NOT_RECRUITING
Research Site, Beijing
RECRUITING
Research Site, Beijing
RECRUITING
Research Site, Beijing
RECRUITING
Research Site, Shenyang
RECRUITING
Research Site, Shenyang
RECRUITING
Research Site, New Delhi
RECRUITING
Research Site, New Delhi
RECRUITING
Research Site, Changchun
RECRUITING
Research Site, Mohali
RECRUITING
Research Site, Shanghai
RECRUITING
Research Site, Nanjing
RECRUITING
Research Site, Varanasi
RECRUITING
Research Site, Xuzhou
RECRUITING
Research Site, Hefei
RECRUITING
Research Site, Bengbu
RECRUITING
Research Site, Jinan
WITHDRAWN
Research Site, Jaipur
WITHDRAWN
Research Site, Jaipur
RECRUITING
Research Site, Hangzhou
RECRUITING
Research Site, Hangzhou
ACTIVE_NOT_RECRUITING
Research Site, Nanchang
RECRUITING
Research Site, Nanchang
RECRUITING
Research Site, Vadodara
RECRUITING
Research Site, Chongqing
ACTIVE_NOT_RECRUITING
Research Site, Changsha
WITHDRAWN
Research Site, Reggio Emilia
ACTIVE_NOT_RECRUITING
Research Site, Wuhan
RECRUITING
Research Site, Nagpur
WITHDRAWN
Research Site, Xiangyang
RECRUITING
Research Site, Zhengzhou
RECRUITING
Research Site, Vinh
RECRUITING
Research Site, Guangzhou
ACTIVE_NOT_RECRUITING
Research Site, Guangzhou
WITHDRAWN
Research Site, Guangzhou
ACTIVE_NOT_RECRUITING
Research Site, Nanning
RECRUITING
Research Site, Bangalore
RECRUITING
Research Site, Mysuru
WITHDRAWN
Research Site, Puducherry
RECRUITING
Research Site, Chengdu
RECRUITING
Research Site, Ho Chi Minh City
RECRUITING
Research Site, Hồ Chí Minh
ACTIVE_NOT_RECRUITING
Research Site, Xi'an
WITHDRAWN
Research Site, Xi'an
WITHDRAWN
Research Site, Ürümqi
ACTIVE_NOT_RECRUITING
Research Site, Ürümqi
RECRUITING
Research Site, Can Tho
RECRUITING
Research Site, New Haven
RECRUITING
Research Site, Boston
RECRUITING
Research Site, Camden
WITHDRAWN
Research Site, Providence
ACTIVE_NOT_RECRUITING
Research Site, Buenos Aires
SUSPENDED
Research Site, CABA
ACTIVE_NOT_RECRUITING
Research Site, Chivilcoy
WITHDRAWN
Research Site, Santa Fe
ACTIVE_NOT_RECRUITING
Research Site, Alfenas
ACTIVE_NOT_RECRUITING
Research Site, Blumenau
ACTIVE_NOT_RECRUITING
Research Site, Natal
ACTIVE_NOT_RECRUITING
Research Site, Porto Alegre
ACTIVE_NOT_RECRUITING
Research Site, Porto Velho
ACTIVE_NOT_RECRUITING
Research Site, São Paulo
ACTIVE_NOT_RECRUITING
Research Site, Taubaté
ACTIVE_NOT_RECRUITING
Research Site, Teresina
ACTIVE_NOT_RECRUITING
Research Site, Vitória
RECRUITING
Research Site, Abbotsford
RECRUITING
Research Site, Kelowna
WITHDRAWN
Research Site, Winnipeg
WITHDRAWN
Research Site, Moncton
RECRUITING
Research Site, Halifax
RECRUITING
Research Site, Brampton
RECRUITING
Research Site, Ottawa
WITHDRAWN
Research Site, Sault Ste. Marie
RECRUITING
Research Site, Toronto
RECRUITING
Research Site, Sherbrooke
RECRUITING
Research Site, Chicoutimi
RECRUITING
Research Site, Montreal
RECRUITING
Research Site, Shandong
RECRUITING
Research Site, Taichung
ACTIVE_NOT_RECRUITING
Research Site, Goztepe Istanbul
RECRUITING
Research Site, Dresden
RECRUITING
Research Site, Leipzig
RECRUITING
Research Site, Roma
ACTIVE_NOT_RECRUITING
Research Site, Chiba
ACTIVE_NOT_RECRUITING
Research Site, Chūōku
ACTIVE_NOT_RECRUITING
Research Site, Chūōku
ACTIVE_NOT_RECRUITING
Research Site, Hidaka-shi
RECRUITING
Research Site, Hirakata-shi
ACTIVE_NOT_RECRUITING
Research Site, Hiroshima
ACTIVE_NOT_RECRUITING
Research Site, Isehara-shi
ACTIVE_NOT_RECRUITING
Research Site, Kagoshima
ACTIVE_NOT_RECRUITING
Research Site, Kōtoku
ACTIVE_NOT_RECRUITING
Research Site, Kyoto
ACTIVE_NOT_RECRUITING
Research Site, Matsuyama
NOT_YET_RECRUITING
Research Site, Nagoya
ACTIVE_NOT_RECRUITING
Research Site, Naha
RECRUITING
Research Site, Okayama
ACTIVE_NOT_RECRUITING
Research Site, Osaka
ACTIVE_NOT_RECRUITING
Research Site, Ota-shi
ACTIVE_NOT_RECRUITING
Research Site, Sapporo
ACTIVE_NOT_RECRUITING
Research Site, Sendai
ACTIVE_NOT_RECRUITING
Research Site, Shimotsuke-shi
ACTIVE_NOT_RECRUITING
Research Site, Shinagawa-ku
ACTIVE_NOT_RECRUITING
Research Site, Shinjuku-ku
ACTIVE_NOT_RECRUITING
Research Site, Suita-shi
ACTIVE_NOT_RECRUITING
Research Site, Takasaki-shi
ACTIVE_NOT_RECRUITING
Research Site, Tsu
ACTIVE_NOT_RECRUITING
Research Site, Yokohama
WITHDRAWN
Research Site, Bialystok
ACTIVE_NOT_RECRUITING
Research Site, Bydgoszcz
RECRUITING
Research Site, Gdansk
WITHDRAWN
Research Site, Koszalin
ACTIVE_NOT_RECRUITING
Research Site, Krakow
NOT_YET_RECRUITING
Research Site, Lodz
NOT_YET_RECRUITING
Research Site, Lodz
WITHDRAWN
Research Site, Lublin
WITHDRAWN
Research Site, Rzeszów
COMPLETED
Research Site, Warsaw
NOT_YET_RECRUITING
Research Site, Warsaw
ACTIVE_NOT_RECRUITING
Research Site, Seoul
ACTIVE_NOT_RECRUITING
Research Site, Seoul
ACTIVE_NOT_RECRUITING
Research Site, Seoul
ACTIVE_NOT_RECRUITING
Research Site, Seoul
ACTIVE_NOT_RECRUITING
Research Site, Seoul
RECRUITING
Research Site, Lund
ACTIVE_NOT_RECRUITING
Research Site, Antalya
RECRUITING
Research Site, Guildford
RECRUITING
Research Site, London
RECRUITING
Research Site, Londonderry
RECRUITING
Research Site, Taunton
RECRUITING
Research Site, York
Lead Sponsor
AstraZeneca
INDUSTRY