A Study of Anlotinib Hydrochloride Capsule Combined With Chemotherapy as First-line Treatment in Subjects With RAS/BRAF Wild Metastatic Colorectal Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

748

Participants

Timeline

Start Date

July 30, 2020

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2025

Conditions
Metastatic Colorectal Cancer
Interventions
DRUG

Anlotinib hydrochloride capsule

Anlotinib hydrochloride capsule 12mg given orally in fasting conditions, once daily in 21-day cycle (14 days on treatment from Day 1-14, 7 days off treatment from Day 15-21);

DRUG

Bevacizumab

Bevacizumab 7.5mg/kg, intravenous drip, on Day 1

DRUG

Oxaliplatin

Oxaliplatin 130mg/m2, intravenous drip, on Day 1;

DRUG

Capecitabine

Capecitabine 850mg/m2 administrated orally twice daily from Day 1-14.

Trial Locations (92)

45000

The First Affiliated Hospital of ZhengZhou University, Zhengzhou

46000

Changzhi People's Hospital, Changzhi

63001

Tangshan People's Hospital, Tangshan

75000

The First Affiliated Hospital of Hebei North University, Zhangjiakou

100029

China-Japan Friendship Hospital, Beijing

100034

Peking University Frist Hospital, Beijing

100050

Beijing Friendship Hospital, Capital Medical University, Beijing

110000

Shengjing Hospital of China Medical University, Shenyang

110801

Liaoning Cancer Hospital, Shenyang

116011

The First Affiliatde Hospital of DaLin Medical University, Dalian

121012

The First Affiliated Hospital of Jinzhou Medical University, Jinzhou

124009

Genertec Liaoyou Gem Flower Hospital, Panjin

130011

Jilin Province FAW General Hospital, Changchun

130012

Jilin Cancer Hospital, Changchun

133099

Yanbian University Hospital, Yanji

135022

Meihekou Central Hospital, Meihekou

150000

Harbin Medical University Affiliated Cancer Hospital, Harbin

150086

The Second Affiliated Hospital of Harbin Medical University, Harbin

170000

Inner Mongolia Autonomous Region Cancer Hospital, Hohhot

200032

Fudan University Shanghai Cancer Center, Shanghai

Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai

Shanghai Tenth People's Hospital, Shanghai

200080

Shanghai General Hospital, Shanghai

Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai

210009

Jiangsu Cancer hospital, Nanjing

Zhongda Hospital Southeast University, Nanjing

210012

Nanjing First Hospital, Nanjing

210022

Nanjing Hospital of C.M., Nanjing

210029

Jiangsu Province People's Hospital, Nanjing

213000

The First Peoples Hospital of Changzhou, Changzhou

214062

Affiliated Hospital of Jiangnan University, Wuxi

225001

Subei People's Hospital of Jiangsu Province, Yangzhou

225300

Jiangsu Taizhou People's Hospital, Taizhou

Taizhou Second People's Hospital, Taizhou

230001

Anhui Provincial Hospital, Hefei

230031

Anhui Cancer Hospital, Hefei

242000

Xuancheng People's Hospital, Xuancheng

247000

The People's Hospital of Chizhou, Chizhou

250117

Shandong Cancer Hospital Affiliated to Shandong Univercity, Jinan

252000

Liaocheng People's Hospital, Liaocheng

261041

Weifang Hospital of Traditional Chinese Medicine, Weifang

264000

Yantai Yuhuangding Hospital, Yantai

272001

Affiliated Hospital of Jining Medical University, Jining

300060

Tianjin Medical University Cancer Institute and Hospital, Tianjin

300450

Peking University BinHai Hospital, Tianjin

310009

The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

313099

Huzhou Cancer Hospital, Huzhou

330000

The Second Affiliated Hospital of Nanchang University, Nanchang

337055

JiangXi PingXiang People's Hospital, Pingxiang

350011

Fujian Medical University Union Hospital, Fuzhou

Fujian Cancer Hospital, Fuzhou

361003

The First Affiliated Hospital of Xiamen University, Xiamen

400042

The First Affiliated Hospital of Chongqing Medical University, Chongqing

408099

Fuling Hospital Affiliated to Chongqing University, Chongqing

410013

Hunan Cancer Hospital, Changsha

430030

Tongji Hospital Affiliated to Tongji Medical College Hust, Wuhan

430079

Hubei Cancer Hospital, Wuhan

441021

Xiangyang Central Hospital, Xiangyang

450008

Henan Cancer Hospital, Zhengzhou

464099

Xinyang Central Hospital, Xinyang

471000

The First Affiliated Hospital of Henan University of Science and Technology, Luoyang

473000

Nanyang Second General Hospital, Nanyang

475000

Huaihe Hospital of Henan University, Kaifeng

510120

The First Affiliated Hospital Of Guangzhou Medical University, Guangzhou

511518

Qingyuan People's Hospital, Qingyuan

515031

Cancer Hospital of Shantou University Medical College, Shantou

524000

Affiliated Hospital of Guangdong Medical University, Zhanjiang

545007

Liuzhou Workers' Hospital, Liuzhou

550000

The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang

550002

Guizhou Provincial People's Hospital, Guiyang

650118

Yunnan Cancer Hospital, Kunming

660000

The First Hospital of Qinhuangdao, Qinhuangdao

710061

Xi'an International Medical Center Hospital, Xi'an

710068

Shaanxi Provincial People's Hospital, Xi'an

The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an

The Second Affiliated Hospital of PLA Air Force Military Medical University, Xi'an

723000

3201 Hospital, Hanzhong

Hanzhong Central Hospital, Hanzhong

730000

Gansu Provincial Cancer Hospital, Lanzhou

Gansu Provincial Hospital, Lanzhou

730030

Lanzhou University Second Hospital, Lanzhou

The First Hospital of Lanzhou University, Lanzhou

810000

Qinghai University Affiliated Hospital, Xining

830000

Affiliated Tumor Hospital of Xinjiang Medical University, Ürümqi

First Affiliated Hospital of Xinjiang Medical University, Ürümqi

844000

The First People's Hospital of Kashgar, Kashgar

024000

Affiliated Hospital of Chifeng University, Chifeng

Chifeng Municipal hospital, Chifeng

Unknown

The First Hospital of China Medical University, Shenyang

030000

Shanxi Provincial Cancer Hospital, Taiyuan

Shanxi Provincial People's Hospital, Taiyuan

All Listed Sponsors
lead

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

INDUSTRY