A Study Evaluating the Safety and Efficacy of EDIT-301 in Participants With Severe Sickle Cell Disease (RUBY)

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

May 4, 2021

Primary Completion Date

August 31, 2025

Study Completion Date

August 31, 2025

Conditions
Sickle Cell DiseaseHemoglobinopathies
Interventions
GENETIC

EDIT-301

Administered by IV infusion after myeloablative conditioning with busulfan.

Trial Locations (24)

10032

Columbia University Medical Center - Department of Pediatrics, New York

Columbia University Medical Center, New York

19104

Children's Hospital of Philadelphia, Philadelphia

27599

The University of North Carolina at Chapel Hill, Chapel Hill

28204

Atrium Health, Charlotte

29425

Medical University of South Carolina, Charleston

30322

Children's Healthcare of Atlanta, Atlanta

33701

Johns Hopkins All Children's Hospital, St. Petersburg

37203

Tristar Medical Group Children's Specialists/Sarah Cannon Center for Blood Cancers, Nashville

39216

University of Mississippi Medical Center, Jackson

43205

Nationwide Children's Hospital, Columbus

43210

The James Cancer Hospital, Columbus

44106

University Hospitals Rainbow Babies & Children's Hospital, Cleveland

44195

Cleveland Clinic, Cleveland

60611

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago

75246

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas

76104

Cook Children's, Fort Worth

80045

Children's Hospital Colorado, Aurora

94609

UCSF Benioff Children's Hospital, Oakland

06511

Smilow Cancer Hospital, New Haven

07601

Hackensack University Medical Center, Hackensack

K1H 8L6

Ottawa Hospital Research Institute, Ottawa

M5G 2M9

Princess Margaret Cancer Centre, Toronto

H3T 1C5

Centre Hospitalier Universitaire Sainte-Justine, Montreal

Sponsors
All Listed Sponsors
lead

Editas Medicine, Inc.

INDUSTRY

NCT04853576 - A Study Evaluating the Safety and Efficacy of EDIT-301 in Participants With Severe Sickle Cell Disease (RUBY) | Biotech Hunter | Biotech Hunter