Repetitive Transcranial Magnetic Stimulation in Early Psychosis and The Functional Connectivity Biotypes

NARecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

August 1, 2020

Primary Completion Date

December 31, 2023

Study Completion Date

December 31, 2024

Conditions
Schizophrenia; PsychosisFirst Episode PsychosisClinical High Risk
Interventions
DEVICE

repetitive transcranial magnetic stimulation (rTMS)

All subjects with early psychosis will be divided into three subgroups determined by their psychotic symptoms and cognition. There are three rTMS strategies: (1) For subgroup 1, characterized by negative symptoms, iTBS over cerebellum and 1 Hz over right DLPFC; (2) For subgroup 2, characterized by cognition deficits, 20 Hz over the left inferior parietal cortex; (3) For subgroup 3, characterized by positive symptoms: 10 Hz over ACC. Ten to twenty sessions of rTMS will be delivered to each patients during the intervention period.

Trial Locations (6)

200030

RECRUITING

Shanghai Mental Health Center, Shanghai

226000

RECRUITING

Nantong Fourth People's Hospital & Nantong Brain Hospital, Nantong

Unknown

NOT_YET_RECRUITING

The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou

RECRUITING

Suzhou Guangji Hospital, Suzhou

RECRUITING

Shenzhen Kangning Hospital, Shenzhen

RECRUITING

Tianjin Anding Hospital, Tianjin

All Listed Sponsors
collaborator

Suzhou Psychiatric Hospital

OTHER

collaborator

Guangzhou Psychiatric Hospital

OTHER_GOV

collaborator

Shenzhen Kangning Hospital

OTHER

collaborator

Tianjin Anding Hospital

OTHER

collaborator

Nantong Fourth People's Hospital & Nantong Brain Hospital

UNKNOWN

lead

Shanghai Jiao Tong University School of Medicine

OTHER