Effect of Fluconazole on the Pharmacokinetics of Pyrotinib in Healthy Subjects

PHASE1CompletedINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

April 16, 2021

Primary Completion Date

May 17, 2021

Study Completion Date

May 17, 2021

Conditions
Healthy Subjects
Interventions
DRUG

Pyrotinib;Fluconazole

"Drug: Pyrotinib Participants received a single oral dose of Pyrotinib tablet on the morning of day1 in treatment period 1.~Drug: Pyrotinib/Fluconazole In treatment period 2, Participants received a single oral dose of pyrotinib tablet on the morning of day9, and received a loading dose of fluconazole capsule on day6 followed by single dose of fluconazole for oral administration from D7 to D18."

Trial Locations (1)

250013

Jinan Central Hospital, Jinan

All Listed Sponsors
lead

Jiangsu HengRui Medicine Co., Ltd.

INDUSTRY