Colchicine for the Stability of Coronary Plaque in Acute Coronary Syndrome (COLOCT)

colchicine is a potent anti-inflammatory drug which is currently recommended for the treatment of pericarditis and acute gout attacks, but also familial Mediterranean fever and Behçet disease. This drug acts on inflammation through inhibition of microtubule polymerization by binding free tubule dimers. Colchicine blunts monocyte and neutrophil invasion at the site of inflammation and reduces intracellular trafficking and thus the release of cytokine and production of reactive oxygen species and a variety of proteolytic enzymes.

the placebo is a drug with no chemical effects but with the same physical characteristics as the experiment drug colchine.