Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosis

PHASE1RecruitingINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

August 3, 2022

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2026

Conditions
AL Amyloidosis
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood and urine specimen collection

PROCEDURE

Bone Marrow Aspiration and Biopsy

Undergo bone marrow aspiration and biopsy

PROCEDURE

Computed Tomography

Undergo CT scan

DRUG

Dexamethasone

Given PO

PROCEDURE

Echocardiography Test

Undergo ECHO

DRUG

Ixazomib Citrate

Given PO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography

Undergo PET scan

PROCEDURE

Transabdominal Ultrasound

Undergo transabdominal ultrasound

DRUG

Venetoclax

Given PO

PROCEDURE

X-Ray Imaging

Undergo x-ray

Trial Locations (16)

10461

ACTIVE_NOT_RECRUITING

Montefiore Medical Center-Einstein Campus, The Bronx

ACTIVE_NOT_RECRUITING

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

ACTIVE_NOT_RECRUITING

Montefiore Medical Center - Moses Campus, The Bronx

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

27599

RECRUITING

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

30322

RECRUITING

Emory University Hospital/Winship Cancer Institute, Atlanta

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

78712

ACTIVE_NOT_RECRUITING

University of Texas at Austin, Austin

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

95817

RECRUITING

University of California Davis Comprehensive Cancer Center, Sacramento

02118

RECRUITING

Boston Medical Center, Boston

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH