475
Participants
Start Date
December 4, 2019
Primary Completion Date
November 30, 2023
Study Completion Date
December 7, 2023
Peginterferon alfa-2b injection
Peginterferon alfa-2b injection (high dose) will be weekly subcutaneous injected for 8 weeks and then stop for 4 weeks, 12 week a cycle, up to 12 cycles (144 weeks) at most. TDF will be taken orally during the whole treatment period. And then followed for 24 weeks after treatment.
Peginterferon alfa-2b injection
Peginterferon alfa-2b injection (low dose) will be weekly subcutaneous injected for 8 weeks and then stop for 4 weeks, 12 week a cycle, up to 12 cycles (144 weeks) at most. TDF will be taken orally during the whole treatment period. And then followed for 24 weeks after treatment.
TDF
Patients will take TDF orally for the first 48 weeks, and then one can choose to continue the single-TDF treatment up to 144 weeks, or may choose to change to receive peginterferon alfa-2b combined TDF therapy for the later 96 weeks, peginterferon alfa-2b will be weekly subcutaneous injected for 8 weeks and then stop for 4 weeks, 12 weeks a cycle. And then followed for 24 weeks after treatment.
Peginterferon alfa-2b injection
Peginterferon alfa-2b injection will be weekly subcutaneous injected for 8 weeks and then stop for 4 weeks, 12 week a cycle, up to 12 cycles (144 weeks) at most. TDF will be taken orally during the whole treatment period. And then followed for 24 weeks after treatment.
Beijing Ditan Hospital, Capital Medical University, Beijing
Beijing Youan Hospital, Capital Medical University, Beijing
Peking University First Hospital, Beijing
The fifth medical center of PLA General Hospital, Beijing
The Second Xiangya Hospital of Central South University, Changsha
Xiangya Hospital Central South University, Changsha
Public Health Clinical Center of Chengdu, Chengdu
Sichuan Provincial People's Hospital, Chengdu
Mengchao Hepatobiliary Hosipital of Fujian Medical University, Fuzhou
The First Affiliated Hospital of Fujian Medical University, Fuzhou
The Ninth Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army, Fuzhou
Guangzhou Eighth People's Hospital, Guangzhou
The Third Affiliated Hospital,SUN YAT-SEN University, Guangzhou
The Fourth Affiliated Hospital of Harbin Medical University, Harbin
The First Affiliated Hospital of Anhui Medical University, Hefei
Nanjing Drum Tower Hospital/The First Affiliated Hospital of Nanjing University Medical School, Nanjing
Huashan Hospital affiliated to Fudan University, Shanghai
Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai
The Sixth People's Hospital of Shenyang, Shenyang
Peiking University Shenzhen Hospital, Shenzhen
The Third People's Hospital of shenzhen, Shenzhen
The First Hospital of Shanxi Medical University, Taiyuan
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin
Tianjin Third Central Hospital, Tianjin
The First Affiliated Hospital of Xinjiang Medical University, Ürümqi
Traditional Chinese Medicine hospital of Xinjiang Uygur Autonomous Region, Ürümqi
Tongji Hospital/Tongji Medical College Huazhong University of Science & Technology, Wuhan
Tangdu Hospital, Xi'an
The First Affiliated Hospital of Xian Jiaotong University, Xi'an
The First Affiliated Hospital of Xiamen University, Xiamen
Xiamen Hospital of Traditional Chinese Medicine, Xiamen
Yanbian University Hospital/Yanbian Hospital, Yanbian
Henan Provincial People's Hospital, Zhengzhou
Peking University First Hospital
OTHER
Xiamen Amoytop Biotech Co., Ltd.
INDUSTRY