Efficacy and Safety of MB-CART2019.1 vs. SoC in Lymphoma Patients

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

168

Participants

Timeline

Start Date

August 18, 2021

Primary Completion Date

January 15, 2025

Study Completion Date

July 31, 2029

Conditions
Diffuse Large B-cell Lymphoma
Interventions
GENETIC

MB-CART2019.1

MB-CART2019.1 is designed to effectively target malignant B cells in patients suffering from late stage haematological B-cell malignancies. MB-CART2019.1 consists of autologous cluster of differentiation CD20/CD19 chimeric antigen receptor (CAR) transduced CD4/CD8 enriched T cells, derived from a leukapheresis and processed by using the CliniMACS Prodigy® device.

DRUG

R-GemOx or BR plus polatuzumab vedotin

Immunochemotherapy will be administered as per arm description.

Trial Locations (53)

1070

Jules Bordet lnstitute, Anderlecht

1090

Medizinische Universitaet Wien - Allgemeines Krankenhaus der Stadt Wien (AKH), Vienna

1097

Del-Pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet, Budapest

3000

Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg, Leuven

4020

Ordensklinikum Linz GmbH Elisabethinen, Linz

4032

Debreceni Egyetem - Orvos es Egeszsegtudomanyi Centrum (DEOEC) (University of Debrecen Medical and Health Science Center), Debrecen

5530

Universite Catholique de Louvain Namur, Centre Hospitalier Universitaire Dinant Godinne Site Godinne, Yvoir

6020

Universitatsklinikum Innsbruck Universitatsklinik fur Innere Medizin V, Innsbruck

8036

Medizinische Universitaetsklinik Graz, Graz

10126

Azienda Ospedaliera San Giovanni Battista Di Torino, Torino

13125

Helios Klinikum Berlin - Buch, Berlin

13273

Centre Paoli Calmettes, Marseille

20099

Asklepios Klinik St. Georg, Hamburg

20246

University Medical Center Hamburg-Eppendorf, Hamburg

28040

Hospital Universitario Fundacion Jimenez Diaz, Madrid

30120

Hospital Universitario Virgen De La Arrixaca (Huva), Murcia

31008

Clinica Universidad de Navarra, Pamplona

31059

Institut Universitaire du Cancer Service d´hématologie, Toulouse

33600

Centre Hospitalier Universitaire de Bordeaux - Hopital Haut-Leveque, Pessac

34090

Centre Hospitalier Universitaire de Montpellier - Hopital Saint-Eloi, Montpellier

35033

CHU de Rennes - Hopital de Pontchaillou, Rennes

37007

Hospital Clinico Universitario de Salamanca, Salamanca

41013

Hospital Universitario Virgen del Rocio, Seville

44093

Centre Hospitalier Universitaire de Nantes (CHU de Nantes) - Hopital Hotel Dieu, Nantes

44892

Universitaetsklinikum Knappschaftskrankenhaus Bochum der Ruhr-Universitat Bochum, Bochum

45147

Universitaetsklinikum Essen, Essen

48149

Universitaetsklinikum Muenster, Münster

50005

University Hospital Hradec Kralove, Hradec Králové

50367

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu. Klinika Hematologii, Nowotworow Krwi i Transplantacji Szpiku, Wroclaw

50937

Universitaetsklinikum Koeln, Cologne

54500

CHU de Nancy Hopitaux de Brabois, Vandœuvre-lès-Nancy

59000

CHRU de Lille - Hopital Claude Huriez, Lille

69120

Universitaetsklinikum Heidelberg, Heidelberg

69495

Centre Hospitalier Lyon Sud, Hospices Civils de Lyon Groupement Hospitalier Sud, Lyon

70852

FNsP Ostrava, Ostrava

72076

University Hospital of Tuebingen, Tübingen

75010

Hospital Saint-Louis - APHP, Paris

81377

Klinikum der Universitat München, Studienzentrale fur Hematologie der Medizinischen Klinik II, München

86000

Centre Hospitalier Universitaire de Poitiers, Poitiers

86156

Universitatsklinikum Augsburg, Augsburg

91054

Klinikum Erlangen der Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen

93053

University Hospital Regensburg, Regensburg

94010

Centre Hospitalier Universitaire (CHU) - Hopital Henri Mondor, Créteil

04103

Universitätsklinikum Leipzig, Leipzig

08661

VUH Santaros Klinikos, Vilnius

1105 AZ

Amsterdam Universitaire Medische Centra (UMC) - locatie Amsterdam Medisch Centrum (AMC), Amsterdam

9713 GZ

University Medical Center Groningen, Groningen

2333 ZA

Leiden University Medical Center (LUMC), Leiden

3015 GC

Erasmus University Medical Center, Rotterdam

08035

Hospital Universitari Vall d'Hebron, Barcelona

08036

Hospital Clinic de Barcelona (Hospital Clinic i Provincial), Barcelona

08907

Catalan Institute of Oncology (ICO) Hospitalet, Barcelona

751 85

Onkologikliniken, Uppsala

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

ICON plc

INDUSTRY

lead

Miltenyi Biomedicine GmbH

INDUSTRY