Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib and Rituximab) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

92

Participants

Timeline

Start Date

January 5, 2022

Primary Completion Date

March 31, 2028

Study Completion Date

March 31, 2028

Conditions
Lymphoplasmacytic LymphomaWaldenstrom Macroglobulinemia
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Bone Marrow Aspiration

Undergo bone marrow biopsy and aspiration

PROCEDURE

Bone Marrow Biopsy

Undergo bone marrow biopsy and aspiration

PROCEDURE

Computed Tomography

Undergo CT or PET/CT

DRUG

Ibrutinib

Given PO

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

BIOLOGICAL

Rituximab

Given IV

DRUG

Venetoclax

Given PO

Trial Locations (113)

10032

ACTIVE_NOT_RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10604

RECRUITING

Memorial Sloan Kettering Westchester, Harrison

11553

RECRUITING

Memorial Sloan Kettering Nassau, Uniondale

11725

RECRUITING

Memorial Sloan Kettering Commack, Commack

12801

RECRUITING

Glens Falls Hospital, Glens Falls

14642

RECRUITING

University of Rochester, Rochester

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

27534

RECRUITING

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

28054

RECRUITING

Levine Cancer Institute-Gaston, Gastonia

28203

RECRUITING

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28328

RECRUITING

Southeastern Medical Oncology Center-Clinton, Clinton

28546

RECRUITING

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

43015

SUSPENDED

Delaware Health Center-Grady Cancer Center, Delaware

SUSPENDED

Grady Memorial Hospital, Delaware

43016

SUSPENDED

Dublin Methodist Hospital, Dublin

43050

SUSPENDED

Knox Community Hospital, Mount Vernon

43055

RECRUITING

Licking Memorial Hospital, Newark

SUSPENDED

Newark Radiation Oncology, Newark

43081

SUSPENDED

Saint Ann's Hospital, Westerville

43123

SUSPENDED

Mount Carmel Grove City Hospital, Grove City

43130

SUSPENDED

Fairfield Medical Center, Lancaster

43213

SUSPENDED

Mount Carmel East Hospital, Columbus

43214

SUSPENDED

Columbus Oncology and Hematology Associates Inc, Columbus

SUSPENDED

Riverside Methodist Hospital, Columbus

43215

SUSPENDED

Grant Medical Center, Columbus

43219

SUSPENDED

The Mark H Zangmeister Center, Columbus

43222

SUSPENDED

Mount Carmel Health Center West, Columbus

43228

SUSPENDED

Doctors Hospital, Columbus

43230

SUSPENDED

Central Ohio Breast and Endocrine Surgery, Gahanna

43302

SUSPENDED

OhioHealth Marion General Hospital, Marion

43551

SUSPENDED

Mercy Health - Perrysburg Hospital, Perrysburg

43608

SUSPENDED

Mercy Health - Saint Vincent Hospital, Toledo

43623

SUSPENDED

Mercy Health - Saint Anne Hospital, Toledo

43701

SUSPENDED

Genesis Healthcare System Cancer Care Center, Zanesville

44903

SUSPENDED

OhioHealth Mansfield Hospital, Mansfield

45601

SUSPENDED

Adena Regional Medical Center, Chillicothe

45662

SUSPENDED

Southern Ohio Medical Center, Portsmouth

45714

SUSPENDED

Strecker Cancer Center-Belpre, Belpre

45750

SUSPENDED

Marietta Memorial Hospital, Marietta

45801

SUSPENDED

Saint Rita's Medical Center, Lima

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

RECRUITING

Huron Gastroenterology PC, Ypsilanti

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

RECRUITING

Trinity Health Medical Center - Brighton, Brighton

48118

RECRUITING

Chelsea Hospital, Chelsea

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

RECRUITING

Trinity Health Medical Center - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48202

RECRUITING

Henry Ford Hospital, Detroit

48341

RECRUITING

Michigan Healthcare Professionals Pontiac, Pontiac

RECRUITING

Newland Medical Associates-Pontiac, Pontiac

RECRUITING

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48346

RECRUITING

Hematology Oncology Consultants-Clarkston, Clarkston

RECRUITING

Newland Medical Associates-Clarkston, Clarkston

48503

RECRUITING

Cancer Hematology Centers - Flint, Flint

SUSPENDED

Genesee Hematology Oncology PC, Flint

RECRUITING

Genesys Hurley Cancer Institute, Flint

RECRUITING

Hurley Medical Center, Flint

48601

RECRUITING

MyMichigan Medical Center Saginaw, Saginaw

48604

SUSPENDED

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48764

RECRUITING

MyMichigan Medical Center Tawas, Tawas City

48912

RECRUITING

University of Michigan Health - Sparrow Lansing, Lansing

50010

RECRUITING

Mary Greeley Medical Center, Ames

RECRUITING

McFarland Clinic - Ames, Ames

50036

RECRUITING

McFarland Clinic - Boone, Boone

50129

RECRUITING

McFarland Clinic - Jefferson, Jefferson

50158

RECRUITING

McFarland Clinic - Marshalltown, Marshalltown

50501

RECRUITING

McFarland Clinic - Trinity Cancer Center, Fort Dodge

54449

ACTIVE_NOT_RECRUITING

Marshfield Medical Center-Marshfield, Marshfield

54476

ACTIVE_NOT_RECRUITING

Marshfield Medical Center - Weston, Weston

54482

ACTIVE_NOT_RECRUITING

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

ACTIVE_NOT_RECRUITING

Marshfield Medical Center - Minocqua, Minocqua

54601

RECRUITING

Gundersen Lutheran Medical Center, La Crosse

54701

ACTIVE_NOT_RECRUITING

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

ACTIVE_NOT_RECRUITING

Marshfield Medical Center-Rice Lake, Rice Lake

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

59102

RECRUITING

Saint Vincent Frontier Cancer Center, Billings

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

62801

RECRUITING

Centralia Oncology Clinic, Centralia

63110

ACTIVE_NOT_RECRUITING

Washington University School of Medicine, St Louis

63128

RECRUITING

Mercy Hospital South, St Louis

63129

ACTIVE_NOT_RECRUITING

Siteman Cancer Center-South County, St Louis

63136

ACTIVE_NOT_RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

ACTIVE_NOT_RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

ACTIVE_NOT_RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63703

RECRUITING

Saint Francis Medical Center, Cape Girardeau

64506

RECRUITING

Heartland Regional Medical Center, Saint Joseph

85719

RECRUITING

Banner University Medical Center - Tucson, Tucson

RECRUITING

University of Arizona Cancer Center-North Campus, Tucson

97015

SUSPENDED

Providence Cancer Institute Clackamas Clinic, Clackamas

97045

RECRUITING

Providence Willamette Falls Medical Center, Oregon City

97132

RECRUITING

Providence Newberg Medical Center, Newberg

97213

RECRUITING

Providence Portland Medical Center, Portland

97225

RECRUITING

Providence Saint Vincent Medical Center, Portland

98026

RECRUITING

Swedish Cancer Institute-Edmonds, Edmonds

98029

RECRUITING

Swedish Cancer Institute-Issaquah, Issaquah

98122

RECRUITING

Swedish Medical Center-First Hill, Seattle

32224-9980

RECRUITING

Mayo Clinic in Florida, Jacksonville

07920

RECRUITING

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07748

RECRUITING

Memorial Sloan Kettering Monmouth, Middletown

07645

RECRUITING

Memorial Sloan Kettering Bergen, Montvale

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH