271
Participants
Start Date
June 21, 2021
Primary Completion Date
July 11, 2024
Study Completion Date
July 11, 2024
L-Arginine Hydrochloride
A one-time L-arginine hydrochloride loading dose of 200 mg/kg will be administered intravenously (IV) followed by a standard dose of 100 mg/kg given by IV three times per day (TID).
Normal saline
A placebo of normal saline will be administered by IV with a loading dose of 2ml/kg followed by 1ml/kg given by IV three times per day (TID).
Children's Hospital of Philadelphia, Philadelphia
Children's National Medical Center, Washington D.C.
Children's Healthcare of Atlanta at Egleston, Atlanta
Nationwide Children's Hospital, Columbus
Medical College of Wisconsin/Wisconsin Children's Hospital, Wauwatosa
Washington University/St. Louis Children's Hospital, St Louis
Texas Children's Hospital/Baylor College of Medicine, Houston
Children's Hospital Los Angeles, Los Angeles
UCSF Benioff Children's Hospital, San Francisco
Children's Healthcare of Atlanta at Hughes Spalding, Atlanta
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Claudia R. Morris
OTHER