Sisonke (Together): OPEN LABEL TRIAL COVID-19

PHASE3CompletedINTERVENTIONAL
Enrollment

477,102

Participants

Timeline

Start Date

February 17, 2021

Primary Completion Date

March 31, 2022

Study Completion Date

March 31, 2022

Conditions
SARS (Severe Acute Respiratory Syndrome)
Interventions
BIOLOGICAL

To monitor the effectiveness of the single dose Ad26.COV2.S COVID-19 vaccine

To monitor the effectiveness of the single dose Ad26.COV2.S COVID-19 vaccine among health care workers (HCW) as compared to the general unvaccinated population in South Africa

Trial Locations (31)

1050

Mzansi Ethical Research Centre, Middleburg

1401

CRISMO Research Centre, Dr Bhekithemba, Germiston

1632

The Aurum Institute: Tembisa Clinical Research Centre, Johannesburg

1809

Perinatal HIV Research Unit Kliptown, Johannesburg

1862

Perinatal HIV Research Unit (PHRU), SOWETO, Johannesburg

2001

Wits RHI: Shandukani Research Centre, Johannesburg

2571

The Aurum Institute Klerksdorp Clinical Research Centre, Klerksdorp

3370

Qhakaza Mbokodo Research Clinic, Ladysmith

3660

Botha's Hill Clinical Research Site, Bothas Hill

4001

CAPRISA eThekwini Clinical Research Site, Dr, Durban

4030

Chatsworth Clinical Research Site, Durban

4400

Tongaat Clinical Research Site, Dr, Tongaat

5100

Nelson Mandela Academic Clinical Research Unit (NeMACRU), Mthatha

6001

PHOENIX Pharma Pty Ltd, Port Elizabeth

6850

South African Vaccine Initiative (SATVI), Dr Angelique Kany Kany, Worcester

7130

Synexus Helderberg Clinical Research Centre, Dr Vera, Somerset West

7505

FAMCRU (Family Clinical Research Unit),, Cape Town

7530

TASK Central, Cape Town

TASK Clinical Research Centre, Cape Town

7781

Emavundleni Research Centre, Cape Town

7784

Khayelitsha CRS, Dr Amy Ward / Dr Graeme Meintjes, Cape Town

7925

Desmond Tutu Health Foundation CTU J52 Old Main Building Groote SchuurHospital, Cape Town

7975

Desmond Tutu Health Foundation - Masiphumelele Research Office, Cape Town

9300

Josha Research, Bloemfontein

Unknown

Themba Lethu HIV Research Unit (CHRU), Dr, Johannesburg

Ndlovu Research Centre, Pretoria

CAPRISA Vulindlela Clinical Research Site, Dr, Durban

0122

Synexus SA - Stanza Clinical Research Centre, Pretoria

0152

Setshaba Research Centre,, Pretoria

0184

Synexus Watermeyer Clinical Research Centre,, Pretoria

0299

The Aurum Institute: Rustenburg Clinical Research Centre, Dr Lawrence, Rustenburg

All Listed Sponsors
collaborator

National Department of Health of South Africa

UNKNOWN

collaborator

National Institute for Communicable Diseases, South Africa

OTHER

collaborator

KwaZulu-Natal Research Innovation and Sequencing Platform - KRISP

UNKNOWN

collaborator

Fred Hutchinson Cancer Center

OTHER

collaborator

Hutchinson Center Research Institute of South Africa (HCRISA)

UNKNOWN

collaborator

Janssen Vaccines & Prevention B.V.

INDUSTRY

collaborator

Bio Analytical Research Corporation

INDUSTRY

collaborator

Dis-Chem Pharmacy

UNKNOWN

collaborator

BioVac

UNKNOWN

collaborator

Biocair

UNKNOWN

collaborator

Right to Care

OTHER

collaborator

Clinical Laboratory Services

OTHER

lead

Wits Health Consortium (Pty) Ltd

OTHER