Role of Simvastatin Microsponges in Treatment of Periodontitis

EARLY_PHASE1CompletedINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

February 10, 2020

Primary Completion Date

August 10, 2020

Study Completion Date

October 10, 2020

Conditions
Periodontitis
Interventions
PROCEDURE

open flap subgingival debridement

After the reevaluation phase after that corrective surgical phase started for the three groups. Local infiltration anesthesia administrated then sulcular flaps raised for the purpose of open flap subgingival debridement.Randomization was then performed and concealment from the assessors.

PROCEDURE

Subgingival injection of chitosan 2% gel

Group (I); injected subgingivally with chitosan 2% gel containing a microsponges formulated drug weekly

PROCEDURE

Subgingival injection of chitosan 2% gel

Group (II); injected subgingivally with chitosan 2% gel containing free drug weekly

PROCEDURE

Subgingival injection of chitosan 2% gel

Group (III); injected subgingivally with placebo chitosan 2% gel weekly

Trial Locations (1)

71111111

Assiut University, Asyut

All Listed Sponsors
lead

Assiut University

OTHER

NCT04836078 - Role of Simvastatin Microsponges in Treatment of Periodontitis | Biotech Hunter | Biotech Hunter