HALO Trial: Haloperidol vs Olanzapine in Hyperactive Delirium in Palliative Care Patients; A Multi-Centre, Randomised-Controlled Trial

PHASE3RecruitingINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

May 18, 2022

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2024

Conditions
HaloperidolAdvanced CancerHyperactive DeliriumOlanzapineEnd-stage Organ Disease
Interventions
DRUG

Haldol 2mg/ml oral solution

"Starting dose: 1mg~Maximum Dose within 24 hours: 6mg~Doses can be escalated every 2 hourly to the maximum doses allowed within 24 hours. If maximum dose of Haloperidol has been reached for the day (within 24 hours), rescue dose of Midazolam 2mg can be used (2mg Q2H PRN)."

DRUG

Olanzapine Actavis 5mg orodispersible tablet

"Starting dose: 2.5mg~Maximum Dose within 24 hours: 15mg~Doses can be escalated every 2 hourly to the maximum doses allowed within 24 hours. If maximum dose of Olanzapine has been reached for the day (within 24 hours), rescue dose of Midazolam 2mg can be used (2mg Q2H PRN)."

Trial Locations (3)

308433

RECRUITING

Tan Tock Seng Hospital, Singapore

308436

RECRUITING

Dover Park Hospice, Singapore

529895

RECRUITING

St. Andrew's Community Hospital, Singapore

All Listed Sponsors
lead

Tan Tock Seng Hospital

OTHER